3 Results for "

murine osteoarthritis

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "murine osteoarthritis" in MCE Product Catalog:

Cat. No.: HY-P10739
CAS No.: 1021155-39-4
Target:  

Exosomes Collagen

Research Areas:  

Inflammation/Immunology

WYRGRL is a selective, high-affinity collagen type II-binding peptide with a IC50 of 140 nM. Collagen type II is the most abundant and specific structural protein in the extracellular matrix of articular cartilage. WYRGRL can precisely target small-molecule compounds such as Dexamethasone (HY-14648) and nanocarrier-engineered exosomes to cartilage, significantly enhancing their therapeutic effects on osteoarthritis .
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Cat. No.: HY-P992358

Target:  

ADAMTS

Research Areas:  

Cardiovascular Disease

GSK2394002 is an antibody inhibitor targeting ADAMTS-4 and ADAMTS-5, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys .
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Cat. No.: HY-P10739C
CAS No.: 1027630-05-2
Target:  

Collagen Apoptosis

Research Areas:  

Inflammation/Immunology

WYRGRLC is a type II collagen-targeting peptide. WYRGRLC specifically binds to type II collagen α1 in articular cartilage in a sequence-dependent manner. WYRGRLC inhibits the binding of WYRGRL-displaying phage (C1-3) to articular cartilage in a sequence-specific manner. WYRGRLC can act as a retention enhancer to improve the cartilage-targeting ability of polymeric nanoparticles and liposomal nanoplatforms, facilitating the delivery of Rapamycin (HY-10219) to chondrocytes. WYRGRLC can be used in studies related to osteoarthritis .
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