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nematode species

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125159
    Derquantel

    PF-00520904

    		 Parasite nAChR Infection
    Derquantel, a spirocyclic anthelmintic, is a competitive, orally active nicotinic acetylcholine receptor (nAChR) antagonist. Derquantel inhibits ACh-induced depolarization with an IC50 of 0.22 μM. By selectively antagonizing nAChRs on the somatic muscles of nematodes, Derquantel causes flaccid paralysis of muscles, thereby dislodging parasites from the host's gastrointestinal tract. Derquantel is applicable to research related to Haemonchus contortus infection and Ascaris suum infection .
    Derquantel
  • HY-178239
    DX-8951 Hydroxy-acid

    		Drug Metabolite AMPK Reactive Oxygen Species (ROS) Inflammation/Immunology
    DX-8951 Hydroxy-acid is a prodrug of phosphoramide. ProAX can effectively increase intracellular ATP levels. DX-8951 Hydroxy-acid activates the AMPK signaling pathway by increasing the AMP/ATP ratio. DX-8951 Hydroxy-acid can enhance mitochondrial function and antioxidant capacity while reducing reactive oxygen species (ROS) levels. DX-8951 Hydroxy-acid has shown significant anti-aging and longevity effects in both human fibroblast and nematode models .
    DX-8951 Hydroxy-acid
  • HY-N8392
    Ascr#9

    		Parasite Infection
    Ascr#9 is a small-molecule pheromone belonging to the ascaroside family, and it is widely present in nematodes. Ascr#9 promotes dispersal or elicits avoidance behavior in various nematode species (such as Caenorhabditis elegans and entomopathogenic nematodes), suggesting that individuals evacuate from adverse environments. Ascr#9 exhibits repellent potential in Meloidogyne incognita .
    Ascr#9
  • HY-178239A
    DX-8951 Hydroxy-acid sodium

    		Drug Metabolite AMPK Reactive Oxygen Species (ROS) Inflammation/Immunology
    DX-8951 Hydroxy-acid sodium is a prodrug of phosphoramide. DX-8951 Hydroxy-acid sodium can effectively increase intracellular ATP levels. DX-8951 Hydroxy-acid sodium activates the AMPK signaling pathway by increasing the AMP/ATP ratio. DX-8951 Hydroxy-acid sodium can enhance mitochondrial function and antioxidant capacity while reducing reactive oxygen species (ROS) levels. DX-8951 Hydroxy-acid sodium has shown significant anti-aging and longevity effects in both human fibroblast and nematode models .
    DX-8951 Hydroxy-acid sodium
  • HY-W420337
    Fluopimomide

    LH2010A

    		 Reactive Oxygen Species (ROS) Infection
    Fluopimomide (LH2010A) is a potent pesticide, widely used for agricultural pest management. Fluopimomide adversely affects the nematodes growth, locomotive behaviors, reproduction, and lifespan, accompanying with enhanced of reactive oxygen species (ROS) generation, lipid and lipofuscin accumulation, and malondialdehyde content. Fluopimomide inhibits antioxidant systems in the nematodes .
    Fluopimomide
  • HY-158423
    NPD8790

    		Mitochondrial Metabolism Parasite Infection
    NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC50 of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths .
    NPD8790
  • HY-183949
    Insecticidal agent 33

    		Insecticide Cholinesterase (ChE) Reactive Oxygen Species (ROS) Infection
    Insecticidal agent 33 is an AChE inhibitor with nematicidal activity. Insecticidal agent 33 impairs locomotor activity of Caenorhabditis elegans, and induces oxidative damage in Caenorhabditis elegans, including elevated reactive oxygen species (ROS) levels, lipofuscin accumulation, lipid deposition, and disrupted cellular homeostasis. Insecticidal agent 33 can be used for the research of plant-parasitic nematode infection .
    Insecticidal agent 33
  • HY-170775
    AChE-IN-83

    		Cholinesterase (ChE) Others
    AChE-IN-83 (compound f1) is an inhibitor of AChE that inhibits the growth of nematodes and acetylcholinesterase in rice seeds and is safe for rice seeds. AChE-IN-83 targets Aphelenchoides oryzae with an LC50 value of 19.0 μg/mL (48 hr). AChE-IN-83 can inhibit the population and behavior of rice nematodes in rice seeds, destroy the nematode cuticle, and lead to the production of reactive oxygen species, lipofuscin, and lipids in the nematodes .
    AChE-IN-83
  • HY-W036015
    (Z)-7-Tetradecen-2-one

    		Parasite Infection
    (Z)-7-Tetradecen-2-one acts as a species-specific nematicide. (Z)-7-Tetradecen-2-one induces terminal embryogenesis, morphological abnormalities, irreversible developmental arrest and increases eggshell permeability in *Pristionchus pacificus* embryos. (Z)-7-Tetradecen-2-one exerts olfactory attraction toward *Pristionchus pacificus*. (Z)-7-Tetradecen-2-one can be used to study the symbiotic relationship between hosts and nematodes .
    (Z)-7-Tetradecen-2-one

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