8 Results for "

ophthalmopathy

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "ophthalmopathy" in MCE Product Catalog:

13
13 Cited Publications
Cat. No.: HY-12068
CAS No.: 1349796-36-6
Purity:  99.46%
Synonyms: XL-147 derivative 1
Target:  

PI3K

Research Areas:  

Cancer

PI3K-IN-1 (XL-147 derivative 1) is a potent inhibitor of PI3K. PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways .
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1
1 Cited Publications
Cat. No.: HY-P99165
CAS No.: 1036734-93-6

Target:  

IGF-1R TSH Receptor

Research Areas:  

Endocrinology

Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research .
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Cat. No.: HY-153213
CAS No.: 1421683-12-6
Org 274179-0 is a low-molecular-weight allosteric thyrotropin receptor (TSH Receptor) antagonist with equipotent follicle-stimulating hormone receptor antagonistic activity and selectivity for the luteinizing hormone receptor. Org 274179-0 binds to the transmembrane domain of the thyrotropin receptor, stabilizes the receptor's inactive state, and blocks agonist-induced and constitutive signaling through the adenylyl cyclase/cAMP and phospholipase C pathways. Org 274179-0 can be used for research on Graves' disease and Graves' ophthalmopathy .
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Cat. No.: HY-P99335
CAS No.: 1792181-33-9
Synonyms: Anti-Human IL17A Recombinant Antibody; SHR-1314

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a recombinant human IgGκ monoclonal antibody and an Interleukin-17A (IL-17A) inhibitor. Vunakizumab binds to IL-17A to inhibit downstream cytokines and block inflammatory signaling. Vunakizumab can be used for the research of chronic plaque psoriasis and ankylosing spondylitis .
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Cat. No.: HY-153213A
Target:  

TSH Receptor

Research Areas:  

Endocrinology

Org 274178-0 is a selective thyroid-stimulating hormone receptor (TSHR) antagonist with a pIC50 value for TSHR is 5.03. Org 274178-0 inhibits the activation of cAMP signaling pathway and phospholipase C (PLC) signaling pathway mediated by thyroid-stimulating hormone (TSH) and TSH receptor-stimulating immunoglobulins (TSIs). Org 274178-0 is promising for research of Graves’ disease and Graves’ ophthalmopathy .
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Cat. No.: HY-P991255

Target:  

IGF-1R

Research Areas:  

Inflammation/Immunology

VRDN-002 is a human monoclonal antibody (mAb) targeting IGF1R/CD221. VRDN-002 reduces inflammation and proptosis in thyroid eye disease (TED). VPI-2690B can be used in Graves ophthalmopathy research .
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Cat. No.: HY-106445
CAS No.: 75985-31-8
Synonyms: BM 41332
Target:  

Drug Derivative

Research Areas:  

Inflammation/Immunology

Ciamexon is selective immunosuppressive agent. Ciamexon can be used to study endocrine ophthalmopathies and diabetes mellitus .
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Cat. No.: HY-12068R
CAS No.: 1349796-36-6
Synonyms: XL-147 derivative 1 (Standard)
Research Areas:  

Cancer

PI3K-IN-1 (Standard) is the analytical standard of PI3K-IN-1. This product is intended for research and analytical applications. PI3K-IN-1 (XL-147 derivative 1) is a potent inhibitor of PI3K. PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways .
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