408 Results for "

penetrating

" in MedChemExpress (MCE) Product Catalog:
Products (408)

408 Results for "penetrating" in MCE Product Catalog:

261
261 Publications Verification
Cat. No.: HY-P0175
CAS No.: 1236188-16-1
Synonyms: 740YPDGFR; PDGFR 740Y-P
Target:  

PI3K Autophagy

Research Areas:  

Cancer

740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .
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45
45 Cited Publications
Cat. No.: HY-P0151
CAS No.: 213546-53-3
Target:  

NF-κB

Research Areas:  

Inflammation/Immunology

SN50 is a cell permeable inhibitor of NF-κB translocation.
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28
28 Cited Publications
Cat. No.: HY-100223
CAS No.: 117591-20-5
Purity:  ≥98.0%
Research Areas:  

Inflammation/Immunology

Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets . Calpeptin is also an inhibitor of cathepsin K .
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21
21 Cited Publications
Cat. No.: HY-100474
CAS No.: 934826-68-3
Purity:  98.99%
SKQ1 is a mitochondrial-targeted antioxidant with the high mitochondrion membrane penetrating ability and potent antioxidant capability .
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17
17 Cited Publications
Cat. No.: HY-P1026
CAS No.: 249537-73-3
Synonyms: VIVIT peptide
NFAT Inhibitor (VIVIT peptide) is an inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT .
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15
15 Cited Publications
Cat. No.: HY-W016420
CAS No.: 26016-99-9
Synonyms: MK-0955 sodium
Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
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15
15 Cited Publications
Cat. No.: HY-B0609
CAS No.: 78964-85-9
Synonyms: MK-0955 tromethamine
Target:  

Bacterial Antibiotic

Research Areas:  

Infection Cancer

Fosfomycin (MK-0955) tromethamine is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
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15
15 Cited Publications
Cat. No.: HY-B1075
CAS No.: 26016-98-8
Synonyms: MK-​0955 calcium
Target:  

Bacterial Antibiotic

Research Areas:  

Infection Cancer

Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
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13
13 Cited Publications
Cat. No.: HY-100672
CAS No.: 174689-39-5
Purity:  ≥98.0%
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively .
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13
13 Cited Publications
Cat. No.: HY-103200
CAS No.: 1135278-41-9
Purity:  99.81%
SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively .
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11
11 Cited Publications
Cat. No.: HY-P0069
CAS No.: 1445179-97-4
Synonyms: AM-111; XG-102
Target:  

JNK

Research Areas:  

Others

D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.
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9
9 Cited Publications
Cat. No.: HY-12290
CAS No.: 91037-65-9
Purity:  99.93%
Synonyms: RGDS peptide; Fibronectin tetrapeptide
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.
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9
9 Cited Publications
Cat. No.: HY-P0278
CAS No.: 99896-85-2
Target:  

Integrin

Research Areas:  

Cancer

RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.
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9
9 Cited Publications
Cat. No.: HY-P0278A
CAS No.: 2378808-45-6
Target:  

Integrin

Research Areas:  

Cancer

RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.
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9
9 Cited Publications
Cat. No.: HY-P1430
CAS No.: 592517-80-1
Synonyms: Cell permeable NFAT inhibitor
11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy .
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9
9 Cited Publications
Cat. No.: HY-P1430A
Synonyms: Cell permeable NFAT inhibitor TFA
11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy .
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8
8 Cited Publications
Cat. No.: HY-P0117
CAS No.: 500992-11-0
Synonyms: Tat-NR2Bct; NA-1
Target:  

iGluR NO Synthase

Research Areas:  

Neurological Disease

Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
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8
8 Cited Publications
Cat. No.: HY-P0117A
CAS No.: 1834571-04-8
Synonyms: Tat-NR2Bct TFA; NA-1 TFA
Target:  

iGluR NO Synthase

Research Areas:  

Neurological Disease

Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
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7
7 Cited Publications
Cat. No.: HY-P0122
CAS No.: 1392278-76-0
Synonyms: c(CRGDKGPDC)
Target:  

Integrin

Research Areas:  

Cancer

iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of agents by first binding to αv-integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.
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6
6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .
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