Search Result
Results for "
photosensitizing
" in MedChemExpress (MCE) Product Catalog:
-
- HY-B0754A
-
|
Hematoporphyrin IX dihydrochloride
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .
|
-
-
- HY-16488
-
|
m-THPC; KW2345
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers .
|
-
-
- HY-D0259
-
|
Erythrosin extra bluish
|
Environmental Pollutants
Fluorescent Dye
|
Others
|
|
Erythrosine B is an artificial dye widely used in the food and textile industries. Erythrosine B is also a novel photosensitizer which has been used to develop animal models.
|
-
-
- HY-P2213
-
|
|
MMP
Apoptosis
|
Cancer
|
|
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .
|
-
-
- HY-134990
-
|
|
Apoptosis
|
Cancer
|
|
Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and research of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma .
|
-
-
- HY-17644
-
|
LUZ11; F2BMet
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Redaporfin (LUZ11) acts as a potent photosensitizer. Redaporfin causes direct antineoplastic effects as well as indirect immune-dependent destruction of malignant lesions .
|
-
-
- HY-128972
-
|
|
Reactive Oxygen Species (ROS)
Apoptosis
|
Others
|
|
Purpurin 18, a derivative of chlorophyll and a type of dihydroporphyrin, is used to produce photosensitizers. Purpurin 18 photodynamic therapy can induce cell apoptosis and has anti-tumor activity .
|
-
-
- HY-16477
-
|
ME2906; Mono-L-aspartyl chlorin e6; NPe6
|
Photosensitizer
|
Cancer
|
|
Talaporfin (ME2906) sodium is a chlorin based photosensitizer. Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT) .
|
-
-
- HY-B0754
-
|
Hematoporphyrin IX
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .
|
-
-
- HY-137473
-
|
Pyropheophorbide-a methyl ester
|
Apoptosis
|
Cancer
|
|
Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth .
|
-
-
- HY-13722
-
-
-
- HY-121310
-
|
|
MOFs
Bacterial
|
Infection
Cancer
|
Phthalocyanine is a photosensitizer. Phthalocyanine has a light-killing effect on bacterial biofilms, effectively inactivating bacteria. Phthalocyanine can be linked to anticancer drugs to target cancer. Phthalocyanine can also be used to develop chemical sensors for studying microbial infections and tumors .
|
-
-
- HY-U00128
-
|
|
Parasite
|
Infection
Inflammation/Immunology
|
|
PPA-904 is a specific phenothiazine photosensitizer in photodynamic research (PDT) research, especially topical application for cutaneous leishmaniasis in vivo .
|
-
-
- HY-126861
-
|
|
Reactive Oxygen Species (ROS)
|
Others
|
|
2'-Deoxy-5-formylcytidine is an effective internal triplet photosensitizer in DNA. 2'-Deoxy-5-formylcytidine could act as a new hot spot in DNA photodamage .
|
-
-
- HY-B1814
-
|
Synkamin; Synkamin base
|
Pyruvate Kinase
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages .
|
-
-
- HY-W130236
-
|
|
Cholinesterase (ChE)
|
Cancer
|
|
Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an Kis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy) .
|
-
-
- HY-164294
-
|
|
Photosensitizer
|
Cancer
|
|
Aluminum phthalocyanine disulfonate is a potential photosensitizer used for the research of Sonodynamic therapy (SDT) .
|
-
-
- HY-W076903
-
|
p-Benzoylaniline; 4-Aminophenyl phenyl ketone; 4-Benzoylaniline
|
Biochemical Assay Reagents
|
Others
|
|
4-Aminobenzophenone (p-Benzoylaniline; 4-Aminophenyl phenyl ketone; 4-Benzoylaniline) is Benzophenone (HY-Y0546) derivative, which behaves as photosensitizer .
|
-
-
- HY-W011376
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-Bromo-2'-deoxycytidine is a DNA photosensitizer. 5-Bromo-2'-deoxycytidine modifies the double-stranded DNA, and determinate the DNA damage 300 nm photon .
|
-
-
- HY-137475
-
-
-
- HY-W010417
-
|
|
Reactive Oxygen Species (ROS)
|
Others
|
|
4-Thiouracil is a thionucleobase with cytostatic properties. 4-Thiouracil can be used as biological photoprobes to detect RNA structures and nucleic acid-nucleic acid contacts. 4-Thiouracil can also act as a strong ultraviolet A (UVA) photosensitizer, providing a source of the reactive oxygen species of O2. 4-Thiouracil is promising for research of photocross linking, photodamage, as well as photodynamic therapy .
|
-
-
- HY-W854659
-
|
Ce6 trisodium
|
Photosensitizer
|
Cancer
|
|
Chlorin e6 Ce6 (trisodium) is a water-soluble derivative of chlorophyll, belonging to the chlorin class of photosensitizers with an absorption wavelength range of 600-670 nm. Chlorin e6 trisodium emits characteristic red fluorescence upon light excitation, enabling real-time identification of tumor boundaries and progression. Chlorin e6 trisodium can be used for the study of photodynamic therapy (PDT) of cancers (bladder cancer) and fluorescence diagnosis of neoplastic lesions .
|
-
-
- HY-129959
-
|
AlClPc
|
Environmental Pollutants
Parasite
MOFs
|
Infection
|
|
Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .
|
-
-
- HY-W035051
-
|
|
MOFs
Fluorescent Dye
|
Infection
Cancer
|
|
TSPP tetrasodium is a photosensitizer that has shown impressive effects in in vivo regression of cancer and microorganism infections (Ex: 413 nm, Em: 640 nm) .
|
-
-
- HY-W127820
-
|
Tetrakis(2-N-methylpyridyl)porphine chloride
|
Biochemical Assay Reagents
Fluorescent Dye
|
Others
|
|
H2TMpyP-2 (tetrakis(2-N-methylpyridyl)porphine) chloride is an active photosensitizer with strong absorption properties in the visible to near-infrared region and excellent singlet oxygen quantum yield. Captisol-TMPyP complexes can be used in supramolecular nanosynthesis to increase singlet oxygen production, improve photostability and better photosensitization, and support photodynamic therapy activity. The Captisol:TMPyP complex also exhibited antibacterial activity against Escherichia coli and was cytotoxic against lung cancer A549 cells .
|
-
-
- HY-W424779
-
|
|
Drug Metabolite
|
Infection
|
|
5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine . 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine .
|
-
-
- HY-175329
-
|
|
Pyroptosis
Reactive Oxygen Species (ROS)
|
Cancer
|
|
BTF-DNBS is a glutathione (GSH)-responsive small-molecule photosensitizer (PS). BTF-DNBS disrupts mitochondrial function and triggers Golgi-mediated pyroptosis, serving as a reactive oxygen species (ROS) generator. BTF-DNBS is promising for research of cancers .
|
-
-
- HY-111959
-
-
-
- HY-W587892
-
|
1-Methoxydecane
|
Biochemical Assay Reagents
|
Others
|
|
Decyl methyl ether is a new type of strong fatty ether. Decyl methyl ether is non-genotoxic and phototoxic/photosensitizing .
|
-
-
- HY-W013521
-
|
|
Environmental Pollutants
|
Others
|
|
Hexyl Salicylate is a commonly used fragrance component, widely applied in cosmetics, perfumes, cleaning products, etc. Hexyl Salicylate has low acute toxicity, no irritation to human skin, no phototoxicity and no photosensitization .
|
-
-
- HY-139286
-
|
Pacsph; Pacsphingosine (d18:1)
|
Biochemical Assay Reagents
|
Others
|
|
Photoclick sphingosine (Pacsph) is a photosensitizing and clickable sphingosine analog. Photoclick sphingosine is metabolized in cells into endogenous lipid metabolic pathways and can be visualized by its clickable alkyne group. Photoclick sphingosine can be used to study intracellular sphingolipid metabolism and subcellular localization .
|
-
-
- HY-137474
-
|
|
Photosensitizer
|
Cancer
|
|
Purpurin 18 methyl ester, a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). Purpurin 18 methyl ester has photodynamic activity to induce cancer cell death .
|
-
-
- HY-175591
-
|
|
Photosensitizer
Apoptosis
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Photosensitizer-7 is a endoplasmic reticulum (ER)-targeted photosensitizer (PS) (λab = 610 nm, λem = 622 nm). Photosensitizer-7shows an IC50 of 4.006 μM in HeLa cells and 3.28 μM in MCF-7 cells under light irradiation. Photosensitizer-7 exhibits dose-dependent cellular uptake and predominant colocalization with ER. Photosensitizer-7 induces dose-dependent intracellular ROS generation, reduces mitochondrial membrane potential, and increases apoptosis upon light irradiation in cells. Photosensitizer-7 significantly inhibits tumor growth in MCF-7 tumor-bearing mice. Photosensitizer-7 can be used for the study of photodynamic anticancer applications .
|
-
-
- HY-162587
-
|
|
Topoisomerase
|
Cancer
|
|
Fagopyrine is a DNA topoisomerase I (Topo I) inhibitor. Fagopyrine is a photosensitizer that can be used in the study of tumors .
|
-
-
- HY-W035145
-
|
|
Drug Intermediate
|
Others
|
|
Tris(2,2′-bipyridine)ruthenium(II)hexafluorophosphate can be used to prepare Ru(II)-containing photodynamic therapy (PDT) photosensitizers .
|
-
-
- HY-W102471
-
|
|
Photosensitizer
|
Others
|
|
3-Acetylbenzophenone (Compound 2) is the photolysis product of Ketoprofen (HY-B0227). 3-Acetylbenzophenone promotes the photoperoxidation reaction of Linoleic acid (HY-N0729), exhibits free radical scavenging and photosensitizing activity .
|
-
-
- HY-P2213A
-
|
|
MMP
Apoptosis
|
Cancer
|
|
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .
|
-
-
- HY-W073074
-
|
|
VSV
|
Infection
|
Mesoporphyrin IX (dihydrochloride) is a photosensitizer that can be used to modify liposomes. Mesoporphyrin IX (dihydrochloride) can insert into lipid vesicles and disrupt the viral membrane structure in vesicular stomatitis virus (VSV), inducing cross-linking of VSV glycoproteins, thereby inhibiting viral activity .
|
-
-
- HY-D1453
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
Immune initiator-1 (Compound 1a) is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic research in melanoma .
|
-
-
- HY-N16417
-
|
|
Apoptosis
Reactive Oxygen Species (ROS)
|
Infection
Cancer
|
|
Elsinochrome C is a photosensitizer. Elsinochrome C relies on light activation to generate reactive oxygen species (ROS) such as singlet oxygen (1O2), inducing apoptosis or directly disrupting pathogen structures. Elsinochrome C is promising for research of skin cancers, HIV-associated infections, and refractory skin diseases .
|
-
-
- HY-N10611
-
|
|
Reactive Oxygen Species (ROS)
Apoptosis
Autophagy
Fungal
Fluorescent Dye
|
Infection
Cancer
|
|
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .
|
-
-
- HY-P99500
-
|
RM-1929; Cetuximab-IRDye-700DX
|
EGFR
|
Cancer
|
|
Cetuximab sarotalocan (RM-1929) is an IRdye700DX (near-infrared photosensitizing dye) conjugate of Cetuximab (anti-EGFR monoclonal antibody). Cetuximab sarotalocan can be used for head and neck cancers research .
|
-
-
- HY-150970
-
|
|
Pyroptosis
|
Cancer
|
|
ICy-OH, an iodinated photosensitizer, is an effective anticancer agent. ICy-OH can be used not only for deep tissue imaging (λex=640 nm，λem=690-740 nm) but also to selectively induce cell death in pancreatic cancer cells via cell pyroptosis pathway .
|
-
-
- HY-137473R
-
|
Pyropheophorbide-a methyl ester (Standard)
|
Apoptosis
Reference Standards
|
Cancer
|
|
Methyl pyropheophorbide-a (Standard) is the analytical standard of Methyl pyropheophorbide-a. This product is intended for research and analytical applications. Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth .
|
-
-
- HY-16488R
-
|
m-THPC (Standard); KW2345 (Standard)
|
Reactive Oxygen Species (ROS)
Reference Standards
|
Cancer
|
|
Temoporfin (Standard) is the analytical standard of Temoporfin. This product is intended for research and analytical applications. Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers .
|
-
-
- HY-D1293
-
-
-
- HY-147690
-
|
|
Photosensitizer
|
Cancer
|
|
Photosensitizer-2 (compound 1) is a organic D-π-A sensitizer against phototoxicity. Photosensitizer-2 contains an acrylic acid moiety that exerts high levels of phototoxicity. Photosensitizer-2 shows antitumor activity against HeLa cells, with IC50 values of 20.9 ± 4.5 μM (dark) and 0.046 ± 0.012 μM (irradiation), respectively .
|
-
-
- HY-W094665
-
|
|
Biochemical Assay Reagents
|
Others
|
|
7-(Diethylamino)-4-(hydroxymethyl)coumarin (compound 10) is an organic compound that can be used as a photosensitizer in organic synthesis .
|
-
-
- HY-13663
-
|
QLT-0074; DRM-05; EA 6
|
Photosensitizer
Drug Derivative
|
Cancer
|
|
Lemuteporfin (QLT-0074) is a benzoporphyrin derivative, diethylene glycol functionalized chlorin-type photosensitizer. Lemuteporfin rapidly sensitizes cells to photodynamic therapy. Lemuteporfin has anticancer activity against acute lymphoblastic leukemia .
|
-
-
- HY-162867
-
|
|
Ferroptosis
|
Cancer
|
Photosensitizer-5 is a photosensitizer. Photosensitizer-5 has cytotoxicity against HeLa and HepG2 cells, with IC50 values of 10.4 nM and 6.9 nM, respectively. Photosensitizer-5 can lead to lipid peroxidation and induces cell death through an iron-independent ferroptosis-like pathway. Photosensitizer-5 shows anti-tumor activity in HeLa tumor-bearing mice .
|
-
- HY-D1648
-
|
|
Fluorescent Dye
|
Others
|
|
8-(2,4,6-Trimethylphenyl)-BODIPY is a highly fluorescent dye, can be used as photosensitizer or synthesize other BODIPY-based photosensitizer (λabs=502 nm, λem=516 nm) (*abs: main absorption maxima) .
|
-
- HY-175214
-
|
|
Reactive Oxygen Species (ROS)
Photosensitizer
|
Cancer
|
|
Antitumor photosensitizer-9 is a near-infrared Photosensitizer (PS) with a high singlet oxygen production rate (relative rate = 1.79). Antitumor photosensitizer-9 exhibits strong phototoxicity against various cancer cells and induces ROS generation under light irradiation. Antitumor photosensitizer-9 inhibits tumor growth in vivo and exhibits excellent anticancer photodynamic therapy (PDT) efficacy at low drug and light doses. Antitumor photosensitizer-9 can be used in photodynamic therapy research .
|
-
- HY-162824
-
|
|
Apoptosis
|
Cancer
|
|
Antitumor photosensitizer-6 (Compound Ru2) shows synergetic type I/II photosensitization and photocatalytic activity upon 595 nm light excitation. Ru2 induces intracellular redox imbalance and affects the biosynthetic and metabolic processes, leading to cell apoptosis. Antitumor photosensitizer-6 can be used for research of photodynamic therapy (PDT) .
|
-
- HY-159153
-
|
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Photosensitizer-4 (compound PS-I) is a potent photosensitizer. Photosensitizer-4 effectively kills cancer cells and inhibits tumor growth under light irradiation .
|
-
- HY-157503
-
|
|
Photosensitizer
|
Cancer
|
|
Photosensitizer-3 is a photosensitizer that exhibits powerful selective killing effects on transfected HEK cells and affibody-targeted A431 cancer cells when exposed to near-infrared light excitation .
|
-
- HY-146416
-
|
|
Photosensitizer
|
Cancer
|
|
Antitumor photosensitizer-2 (Compound 11) is a potent photosensitizer. Antitumor photosensitizer-2 has outstanding photodynamic anti-tumor effects without obvious skin photo-toxicity, and can act as new agent candidates for photodynamic research .
|
-
- HY-146414
-
|
|
Photosensitizer
|
Cancer
|
|
Antitumor photosensitizer-1 (Compound 8) is a potent photosensitizer. Antitumor photosensitizer-1 has outstanding photodynamic anti-tumor effects without obvious skin photo-toxicity, and can act as new agent candidates for photodynamic research .
|
-
- HY-145265
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial photosensitizer-1 is a promising candidate as the antimicrobial photosensitizer for combating pathogenic microorganism infections. Antimicrobial photosensitizer-1 exhibits an impressive antimicrobial efficacy in S. aureus-infected mice wounds .
|
-
- HY-156092
-
|
|
BCRP
Apoptosis
|
Cancer
|
|
Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. Antitumor photosensitizer-4 is a photosensitizer (PS) consisting of a conjugate of dasatinib (HY-10181) and imatinib (HY-15463). Antitumor photosensitizer-4 induces apoptosis and ROS production and exhibits strong phototoxicity to HepG2 and B16-F10 cells .
|
-
- HY-159005
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TDTM is a photosensitizer, that promotes the generation of ROS with induction of the light. TDTM can be used for synthesis of Janus liposozyme .
|
-
- HY-157943
-
|
HAL
|
Fluorescent Dye
|
Cancer
|
|
Hexyl 5-aminolevulinate (HAL) is a photosensitizer, and can increase the efficiency of PDT due to the high lipophilicity. Hexyl 5-aminolevulinate can be used for research of photodynamic therapy (PDT) .
|
-
- HY-D1472
-
|
|
Fluorescent Dye
|
Others
|
|
Azure A eosinate is a dye for hematological and histological applications. Azure A eosinate can be used as new photosensitizer prototypes to determine growth inhibition of Candida albicans .
|
-
- HY-155070
-
|
|
DNA/RNA Synthesis
Apoptosis
|
Cancer
|
|
SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer .
|
-
- HY-W504836
-
|
|
Photosensitizer
|
Neurological Disease
|
Deuteroporphyrin IX (dihydrochloride) is a photosensitizer with high lipophilicity and amphiphilicity, capable of providing photosensitivity for cell membrane systems. Deuteroporphyrin IX (dihydrochloride) can induce irreversible discharge elimination in individual neurons .
|
-
- HY-168261
-
|
|
Ferroptosis
|
Cancer
|
|
CQ-ER is a Coumarin (HY-N0709)-Quinazolinone based endoplasmic reticulum (ER)-targeted photosensitizer. CQ-ER can cause ferroptosis, thereby enhancing photodynamic therapy (PDT) .
|
-
- HY-149778
-
|
|
Fungal
|
Infection
|
|
Antifungal agent 87(10) acts as a highly potent PDT antimycotic photosensitizer (PDT-IC50 = 1 nM for T. rubrum) .
|
-
- HY-D1673
-
|
|
Fluorescent Dye
|
Cancer
|
|
Tetrabromorhodamine 123 (TBR) bromide is a photosensitizer. Tetrabromorhodamine 123 bromide can be used for the research of photo dynamic therapy (PDT) and cancer .
|
-
- HY-126841
-
|
|
Photosensitizer
|
Cancer
|
|
5-Methoxysterigmatocystin is a mycotoxin with cytotoxic and genotoxic properties. 5-Methoxysterigmatocystin exhibits cytotoxicity against cancer cells A549 and HepG2 (IC50 of 5.5 and 0.7 μM), and induces DNA damage. 5-Methoxysterigmatocystin is a photosensitizer, which utilizes the visible to generate singlet oxygen ( 1O2) .
|
-
- HY-144314
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
PSDalpha is an ERα degrader conjugating photosensitizer (PS), triphenylamine benzothiadiazole (TB) and 17β-estradiol via an acetylene bond. PSDalpha shows excellent anti-proliferation performance on MCF-7 cells. The maximum absorption wavelength of PSDalpha in the visible region is located at 465 nm .
|
-
- HY-157051
-
|
|
Photosensitizer
|
Cancer
|
|
[Ru(DIP)2TAP]Cl2, Ruthenium(II) polypyridyl compound, is a photosensitizer. [Ru(DIP)2TAP]Cl2 can be used for the research of photodynamic therapy (PDT) .
|
-
![[Ru(DIP)2TAP]Cl2](//file.medchemexpress.com/product_pic/hy-157051.gif)
- HY-D2620
-
|
|
Photosensitizer
Reactive Oxygen Species (ROS)
Ferroptosis
|
Cancer
|
|
CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LDs). CAR-2 exhibits phototoxicity in breast cancer cells with IC50 of 0.01-0.02 μM. CAR-2 exhibits antitumor efficacy in 4T1 xenograft mouse models .
|
-
- HY-150015
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
4,5'-Dimethylangelicin-NHS is a modified 4,5'-Dimethylangelicin containing an NHS. 4,5'-Dimethylangelicin is an angular furocoumarin with photochemical and photosensitizing properties. 4,5'-Dimethylangelicin can inhibit the DNA and RNA syntheses in Ehrlich ascites tumor cells alter irradiation at 365 nm. 4,5'-Dimethylangelicin has potential as a photochemotherapy agent .
|
-
- HY-151940
-
|
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Mal-Pc is a versatile molecular photosensitizer designed based phthalocyanine and maleimides. Mal-Pc can react with GSH to deplete GSH and reduce aggregation, thereby improving ROS (Reactive Oxygen Species)-mediated effect of photodynamic therapy (PDT) in cancer cells .
|
-
- HY-163691
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC50 is 0.2 and 0.05 μM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model .
|
-
- HY-D1293A
-
-
- HY-147521
-
|
|
Necroptosis
|
Cancer
|
|
Antitumor photosensitizer-3 (Compound I) is a chlorin derivative. Antitumor photosensitizer-3 induces tumor cells apoptosis and necrosis under 650 nm laser irradiation. Antitumor photosensitizer-3 exhibits lower skin photo-toxicity than positive reference m-THPC in vivo .
|
-
- HY-162958
-
|
|
Apoptosis
TrxR
|
Cancer
|
|
Photosensitizer-6 (Compound 4) is a gold (I) complex and exhibits inhibitory activity against TrxR. Photosensitizer-6 induces apoptosis in 4T1 cell, targets and eradicates tumors through chemo-phototherapy and immunogenic cell death under light exposure. Photosensitizer-6 can be used for tumor imaging .
|
-
- HY-163034
-
|
|
Apoptosis
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Antitumor photosensitizer-5 (Ru2) is a photosensitizer which effectively target tumor mitochondria with an IC50 of 0.3 μM for phototoxicity to A549 cells. Under 460 nm light irradiation, antitumor photosensitizer-5 induces the generation of reactive oxygen species and NADH depletion, causes mitochondrial damage and activation of caspase-3, inducing apoptosis and suppressing cell migration. Antitumor photosensitizer-5 has the potential to prevent the growth of malignant tumors, therefore, shows the potential to be applied to photodynamic therapy .
|
-
- HY-W395410
-
|
|
Drug Intermediate
|
Others
|
|
2-Acetyldibenzofuran (2e) is a dibenzofuran derivative that can be used in the synthesis of photosensitizers .
|
-
- HY-145241
-
|
|
Photosensitizer
|
Neurological Disease
|
|
TBTDC is a highly efficient multifunctional organic photosensitizer with aggregation-induced emission for in vivo bioimaging and photodynamic research.
|
-
- HY-157053
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
[Ru(dppn)2phen](PF6)2 (compound 4) is a polypyridylruthenium compound used in photodynamic therapy (PDT). [Ru(dppn)2phen](PF6)2 is normally nontoxic under dark conditions and induces mitochondrial respiratory damage upon light exposure. [Ru(dppn)2phen](PF6)2 exhibits high levels of singlet oxygen quantum yield and phototoxicity against cancer cells .
|
-
2](//file.medchemexpress.com/product_pic/hy-157053.gif)
- HY-123727
-
|
|
Fluorescent Dye
|
Others
|
|
Acid blue 120 is an azo dye, which can be utilized in textile dyeing, food and pharmaceutical coloring, photosensitizer, sensor and surface modification .
|
-
- HY-128419
-
|
|
Photosensitizer
|
Others
|
|
Biguanidinium-porphyrin is a mitochondria-targeting photosensitizer. Biguanidinium-porphyrin distributes within cell membranes with a large component in vesicles that correlated to some extent with the lysosomes and, upon longer exposures, in mitochondria and the cytosolic membrane .
|
-
- HY-176725
-
-
- HY-164294A
-
|
|
Photosensitizer
|
Others
|
|
Aluminum phthalocyanine disulfonate disodium is a potential photosensitizer used for the research of Sonodynamic therapy (SDT) .
|
-
- HY-182066
-
|
|
PANoptosis
|
Cancer
|
|
Photosensitizer-9 is an iridium (III)-based photosensitizer with anti-melanoma activity. Photosensitizer-9 exhibits significant phototoxicity (IC50=0.98 μM) and an ideal phototoxicity index (PI=3.05). Under light irradiation, Photosensitizer-9 generates large amounts of intracellular •OH in an oxygen-independent manner. Photosensitizer-9 mediates photodynamic therapy under hypoxic conditions and synergistically activates PANoptosis (by upregulating cleaved Caspase-3, GSDMD-N, p-MLKL), ferroptosis (by disrupting the GSH-GPX4-LPO axis), apoptosis, pyroptosis and necroptosis in melanoma cells. Photosensitizer-9 induces immunogenic cell death by promoting the release of damage-associated molecular patterns under hypoxic conditions and increases the maturation rate of dendritic cells. Photosensitizer-9 reduces tumor volume in melanoma-bearing mice. Photosensitizer-9 is applicable to relevant studies on melanoma .
|
-
- HY-D2986
-
|
|
Photosensitizer
Bacterial
|
Infection
|
|
TBD–anchor is a water-soluble, positively charged AIE photosensitizer. TBD–anchor can specifically bind to bacterial membranes and efficiently produce 1O2. TBD–anchor has bactericidal activity against various bacteria and good biocompatibility. TBD–anchor can be used for research on bacterial infections .
|
-
- HY-175163
-
|
|
Photosensitizer
|
Cancer
|
|
TPAPyN is a nitroreductase(NTR)-responsive type I photosensitizer. TPAPyN facilitates the imaging of hypoxic cancer cells and image-guided photodynamic therapy (PDT). TPAPyN does not emit fluorescence in the aqueous environment, but restores when NTR cleaves the nitrofuran quencher with aggregation-induced emission. TPAPyN can be used as a fluorescent probe for specific imaging of hypoxic cancer .
|
-
- HY-182785
-
|
|
Photosensitizer
|
Cancer
|
|
Photosensitizer-10 is a glutathione (GSH)-activatable photosensitizer. Photosensitizer-10 shows minimal photoactivity in the absence of glutathione, and generates a highly active species upon reaction with glutathione to induce photo-cytotoxicity. Photosensitizer-10 exhibits selective photo-cytotoxicity toward cancer cells with elevated intracellular glutathione levels while sparing normal cells. Photosensitizer-10 can be used for the research of cancer, such as lung carcinoma and skin carcinoma .
|
-
- HY-183570
-
|
|
Photosensitizer
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Antitumor photosensitizer-11 is a type-I carbazole/benzindolium photosensitizer with antitumor activity. Antitumor photosensitizer-11 induces ROS generation via a type-I pathway, forming superoxide anions and hydroxyl radicals. Antitumor photosensitizer-11 triggers immunogenic cell death in cancer cells via enhanced oxidative stress. Antitumor photosensitizer-11 exhibits antiproliferative activity in normoxic and hypoxic environments, inhibits breast cancer tumor growth in vivo, and promotes dendritic cell maturation and T cell infiltration. Antitumor photosensitizer-11 can be used for the research of cancer, such as breast cancer .
|
-
- HY-182919
-
|
|
Cuproptosis
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Antitumor photosensitizer-10 is an antitumor photosensitizer. Upon near-infrared irradiation, Antitumor photosensitizer-10 generates superoxide anions, reduces the copper-binding capacity of glutathione, releases copper ions, and thereby induces cuproptosis in tumor cells (cuproptosis). Antitumor photosensitizer-10 can be used in breast cancer-related research .
|
-
- HY-162825
-
|
|
Photosensitizer
|
Cancer
|
|
Antitumor photosensitizer-7 (compound 15) is a photosensitizer with anti-cancer activity. Antitumor photosensitizer-7 exhibits significant cytotoxicity against the G361 melanoma cell line under 414 nm blue light irradiation .
|
-
- HY-170883
-
|
|
Photosensitizer
|
Cancer
|
|
Type-I/-II Photosensitizer-1 (compound 8b) is a photosensitizer with anticancer activity. Type-I/-II Photosensitizer-1 exhibits significant phototoxicity against both A549 and 4T1 tumor cells. Type-I/-II Photosensitizer-1 shows a strong oxygen-independent antitumor effect under laser irradiation (IC50=1.50-1.76 μM) .
|
-
- HY-180169
-
|
|
Photosensitizer
Drug Derivative
|
Cancer
|
|
Photosensitizer-8 (Compound 4), 2-anthrol derivative, is an alkaline phosphatase (ALP)-activatable photosensitizer. Photosensitizer-8 undergoes a phosphate ester hydrolysis reaction in the presence of ALP, rapidly converting into the active photosensitizer 2-anthrol. Photosensitizer-8 exhibits cytotoxicity against ALP-overexpressing cancer cells (HeLa, A549, HCT116) after light exposure, with IC50 values of 14.3 μM, 21.6 μM and 17.5 μM, respectively, while showing no significant cytotoxicity against normal lung fibroblasts (WI-38) (IC50 ≥ 30 μM). Photosensitizer-8 can be used in photodynamic therapy research for ALP-overexpression-related cancers .
|
-
- HY-183797
-
|
|
|
Cancer
|
|
Antitumor agent-218 is an aggregation-induced emission (AIE)-based photosensitizer. Antitumor agent-218 selectively accumulates in the endoplasmic reticulum, and generates ROS within the endoplasmic reticulum upon irradiation to induce necroptosis of tumor cells. Antitumor agent-218 can be used in cancer-related research .
|
-
- HY-W011350
-
-
- HY-W014331
-
|
|
Herbicide
Photosensitizer
|
Others
|
|
Atraton is a 1,3,5-triazine Herbicide and photodegradable substrate. Atraton undergoes photodegradation under the action of the photosensitizer acetone .
|
-
- HY-W094745
-
|
|
MOFs
Photosensitizer
|
Inflammation/Immunology
|
|
5,10,15,20-Tetrakis(4-chlorophenyl)porphyrin (Compound 5) is a photosensitizer. 5,10,15,20-Tetrakis(4-chlorophenyl)porphyrin shows no significant photodynamic cytotoxicity. 5,10,15,20-Tetrakis(4-chlorophenyl)porphyrin is mainly used for the optimization of photosensitizer structure in photodynamic therapy (PDT) for psoriasis .
|
-
- HY-183743
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Chlorophyllide A is a tetrapyrrole metabolite late in the biosynthesis of chlorophylls and bacteriochlorophylls. Chlorophyllide A can be used as a photosensitizer for the research of photodynamic therapy-related research .
|
-
- HY-D2979
-
|
|
Photosensitizer
|
Cancer
|
|
OBADC-TPA is a new type of photosensitizer. OBADC-TPA is commonly used to modify nanoparticles. OBADC-TPA can be used for precise optical imaging and research of lymphoma .
|
-
- HY-N10902
-
-
- HY-170436
-
|
|
Photosensitizer
Apoptosis
|
Cancer
|
|
NFh-NMe-2 is a photosensitizer, that interacts with nitroreductase, generates singlet oxygen in tumor cells, exhibits cytotoxicity in cancer cells, and induces apoptosis. NFh-NMe-2 exhibits antitumor efficacy in mouse models .
|
-
- HY-125665
-
|
|
Apoptosis
|
Cardiovascular Disease
Cancer
|
|
Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research .
|
-
- HY-162129
-
|
|
Photosensitizer
|
Cancer
|
|
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC50 value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .
|
-
- HY-N1453
-
|
|
Apoptosis
Fungal
Parasite
|
Infection
Cancer
|
|
Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities .
|
-
- HY-155003
-
|
|
Fluorescent Dye
|
Cancer
|
|
TPEQM-DMA is a NIR-II photosensitizer. TPEQM-DMA accumulates in cancerous mitochondria, and inhibits cancer cell growth. TPEQM-DMA has potent type-I phototherapeutic efficacy to overcome the intrinsic pitfalls of PDT in combating hypoxic tumors .
|
-
- HY-145538
-
|
5'-Deoxyguanylic acid disodium hydrate
|
DNA/RNA Synthesis
|
Others
|
|
2'-Deoxyguanosine 5'-monophosphate (5'-Deoxyguanylic acid; dGMP) disodium hydrate is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism) .
|
-
- HY-113011
-
|
|
Endogenous Metabolite
|
Others
|
|
Maltotriose is a maltooligosaccharide and a specific inducer of the Escherichia coli maltose operon. The oligosaccharide structure of Maltotriose acts as a highly efficient drug delivery carrier, which significantly enhances the targeting ability and water solubility of photosensitizers in photodynamic therapy for pancreatic cancer .
|
-
- HY-Y1129
-
|
|
Photosensitizer
Apoptosis
|
Inflammation/Immunology
|
|
3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .
|
-
- HY-W075248
-
-
- HY-D0259R
-
|
Erythrosin extra bluish (Standard)
|
Fluorescent Dye
Reference Standards
|
Others
|
|
Erythrosine B (Standard) is the analytical standard of Erythrosine B. This product is intended for research and analytical applications. Erythrosine B is an artificial dye widely used in the food and textile industries. Erythrosine B is also a novel photosensitizer which has been used to develop animal models.
|
-
- HY-Y1819R
-
-
- HY-W011240
-
|
Methforylthiazidine; Rontyl
|
Sodium Channel
Chloride Channel
|
Metabolic Disease
Endocrinology
|
|
Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas .
|
-
- HY-Y1819
-
|
|
Reactive Oxygen Species (ROS)
Mitochondrial Metabolism
|
Endocrinology
|
|
2-Acetonaphthone is a synthetic fragrance material. 2-Acetonaphthone increases ROS under UVA/sunlight, leading to endoplasmic reticulum stress and decreased mitochondrial membrane potential. 2-Acetonaphthone can be used as an adulterant in a variety of cosmetics. 2-Acetonaphthone can be used for the study of skin keratinization
|
-
- HY-W011240R
-
|
Methforylthiazidine (Standard); Rontyl (Standard)
|
Sodium Channel
Chloride Channel
Reference Standards
|
Metabolic Disease
Endocrinology
|
|
Hydroflumethiazide (Standard) is the analytical standard of Hydroflumethiazide. This product is intended for research and analytical applications. Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas .
|
-
- HY-168854
-
|
|
Photosensitizer
Reactive Oxygen Species (ROS)
|
Cancer
|
|
TBC-1 is a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). TBC-1 efficiently generats Type-I ROS and endoplasmic reticulum targeting ability. TBC-1 shows biocompatibility and PDT efficiency in vitro under both normoxia and hypoxia .
|
-
- HY-B1157
-
|
Trisoralen; Trioxysalen; TMP
|
DNA Alkylator/Crosslinker
|
Inflammation/Immunology
|
|
Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation .
|
-
- HY-159485
-
|
|
Phosphatase
|
Cancer
|
|
NFh-ALP is an alkaline phosphatase (ALP)-activatable photosensitizer. NFh-ALP could be activated by ALP in cells and generate 1O2 under 808 nm excitation, effectively killing tumor cells by inducing apoptosis and having good biocompatibility. The maximum absorption wavelength of NFh-ALP is about 656 nm .
|
-
- HY-W127725
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Thymolphthalexon (tetrasodium) is an organic compound commonly used as a reagent in biochemical assays. It belongs to the family of thioxanthone derivatives and has strong antioxidant properties. Thymolphthalexon has several applications in the study of free radical response, oxidative stress, and aging. In addition, it can be used as a photosensitizer in photodynamic therapy for the improvement of cancer and other diseases.
|
-
- HY-B0146
-
Verteporfin
Maximum Cited Publications
266 Publications Verification
CL 318952
|
YAP
Apoptosis
Autophagy
Photosensitizer
|
Cancer
|
|
Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis . Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation .
|
-
- HY-D2309
-
|
|
Fluorescent Dye
Photosensitizer
|
Cancer
|
|
IRDye700Dx Maleimide is a Photosensitizer. When conjugated with HER2 Affibody and activated by near-infrared light, IRDye700Dx Maleimide induces death in HER2-positive breast cancer cells without causing damage to HER2-negative breast cancer cells .
|
-
- HY-N6743
-
|
CGP049090
|
PKC
|
Cancer
|
|
Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations .
Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM .
|
-
- HY-113011R
-
|
|
Reference Standards
Endogenous Metabolite
|
Others
|
|
Maltotriose (Standard) is the analytical standard of Maltotriose (HY-13011). This product is intended for research and analytical applications. Maltotriose is a maltooligosaccharide and a specific inducer of the Escherichia coli maltose operon. The oligosaccharide structure of Maltotriose acts as a highly efficient drug delivery carrier, which significantly enhances the targeting ability and water solubility of photosensitizers in photodynamic therapy for pancreatic cancer.
|
-
- HY-N1453R
-
|
|
Reference Standards
Apoptosis
Fungal
Parasite
|
Infection
Cancer
|
|
Hypocrellin B (Standard) is the analytical standard of Hypocrellin B. This product is intended for research and analytical applications. Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities[1][2][3].
|
-
- HY-W011577
-
|
Dibenz[a,c]anthracene
|
Photosensitizer
|
|
|
Benzo[f]tetraphene (Dibenz[a,c]anthracene) is a polycyclic aromatic hydrocarbon with significant antitumor activity. Benzo[f]tetraphene is used as a luminescent probe in cell biology research and can effectively detect reactive oxygen species in biological systems. Benzo[f]tetraphene can also be used as a potential photosensitizer and shows good application prospects in photodynamic inhibition.
|
-
![Benzo[f]tetraphene](//file.medchemexpress.com/product_pic/hy-w011577.gif)
- HY-13594
-
|
Ce6
|
MOFs
Bcl-2 Family
Caspase
PARP
Apoptosis
Fluorescent Dye
|
Infection
Cancer
|
|
Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer .
|
-
- HY-185390
-
|
Liposomal verteporfin
|
Liposome
YAP
|
Cancer
|
|
Verteporfin liposome is a liposome-encapsulated form of Verteporfin (HY-B0146). Verteporfin is a photosensitizer used in photodynamic therapy to eliminate abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin liposome prolongs drug circulation time and provides slow release, allowing the drug to accumulate in newly formed blood vessels.
|
-
- HY-147915
-
|
|
Carboxylesterase (CES)
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids .
|
-
- HY-N12630
-
|
Mycosporine-Gly
|
Mitochondrial Metabolism
Bacterial
|
Others
|
|
Mycosporine glycine (Mycosporine-Gly) is a potent singlet oxygen quencher. Mycosporine glycine can effectively suppress various detrimental effects of the Type-II photosensitization in biological systems, such as inactivation of mitochondrial electron transport, lipid peroxidation of microsomes, hemolysis of erythrocytes and growth inhibition of E.coli. Mycosporine glycine can be used for protecting marine organisms against sunlight damage .
|
-
- HY-132141
-
|
5-Propargylamino-dUTP
|
DNA/RNA Synthesis
|
Others
|
|
5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-161341
-
|
|
Photosensitizer
|
Cancer
|
|
β-Glucuronidase responsive conjugate 1 (compound 3) is a well-balanced photosensitizer which has photodynamic activity. β-Glucuronidase responsive conjugate 1 inhibits T-24 cell viability and growth with an IC50 of 0.2 μM. β-Glucuronidase responsive conjugate 1 can used to study bladder cancers .
|
-
- HY-W127809
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Chlorin e4 is an organic compound belonging to the family of chlorins, which are macrocyclic compounds with a similar structure to porphyrins. It is commonly used to improve photodynamic therapy for cancer and other diseases. Chlorin e4 has multiple applications in medical research, including as a photosensitizer for localized tumor destruction. In addition, its antimicrobial properties and potential use in disinfection applications were investigated.
|
-
- HY-B1157R
-
|
Trisoralen (Standard); Trioxysalen (Standard); TMP (Standard)
|
Reference Standards
DNA Alkylator/Crosslinker
|
Inflammation/Immunology
|
|
Trioxsalen (Standard) is the analytical standard of Trioxsalen. This product is intended for research and analytical applications. Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation .
|
-
- HY-Y1129S
-
|
|
Isotope-Labeled Compounds
Photosensitizer
Apoptosis
|
Inflammation/Immunology
|
|
3-Hydroxypyridine-d4 is the deuterium labeled 3-Hydroxypyridine (HY-Y1129). 3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .
|
-
- HY-W746295
-
|
|
Isotope-Labeled Compounds
Apoptosis
Photosensitizer
|
Inflammation/Immunology
|
|
3-Hydroxypyridine-d5 is the deuterium labeled 3-Hydroxypyridine (HY-Y1129). 3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .
|
-
- HY-161981
-
|
|
Apoptosis
|
Cancer
|
|
Antitumor agent-187 (compound I3) is a photosensitizer based on 5,15-diaryltetrabenzoporphyrin with a maximum absorption wavelength of ~668 nm and anticancer activity. Antitumor agent-187 can induce apoptosis and can be used in photodynamic therapy (PDP). Antitumor agent-187 selectively accumulates at tumor sites and has real-time fluorescence imaging capabilities .
|
-
- HY-128973
-
|
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Pyropheophorbide-a (Ppa) is a photosensitizer used in photodynamic therapy (PDT) for tumors. Pyropheophorbide-a exhibits phototoxic effects on tumor cells, such as cervical cancer cells, and also has anti-lipogenesis activity. Pyropheophorbide-a shows potential for research in the fields of cancer and age-related macular degeneration (AMD). Pyropheophorbide-a derivatives also demonstrate inhibitory activity against tumor cells .
|
-
- HY-W738979
-
|
|
Photosensitizer
|
|
|
Silicon naphthalocyanine dichloride is a photosensitizer with potential anti-tumor activity. Silicon naphthalocyanine dichloride is used as a cancer-inhibiting compound in photodynamic therapy. Silicon naphthalocyanine dichloride can effectively absorb light energy of a specific wavelength, thereby generating oxygen free radicals that help destroy cancer cells. The biocompatibility of Silicon naphthalocyanine dichloride makes it show good prospects in medical applications.
|
-
- HY-D1719A
-
|
|
Fluorescent Dye
|
Cancer
|
|
Cypate is a near-infrared fluorescent dye that belongs to the family of photosensitizers. Cypate has high photostability and optical properties, and is often used in near-infrared optical imaging, as well as optical imaging, tumor marking, and drug delivery. In addition, Cypate is also used as a molecular probe and combined with targeting molecules (such as CBT or small interfering RNA) to achieve efficient detection and imaging of specific cells or tissues .
|
-
- HY-171481
-
|
SACD
|
CDK
|
Cancer
|
|
Thio-acridone (SACD) is a photosensitizer (HAF-PSs). Thio-acridone forms a long-lived triplet state upon excitation by 470 nm visible light,, ultimately generating singlet oxygen to damage the structures and functions of target cells such as cancer cells. Thio-acridone is promising for research of cancers . Thio-acridone is a CDK4/Cyclin D1 inhibitor (IC50 = 2 uM) .
|
-
- HY-D2353
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .
|
-
- HY-N2552
-
|
|
Pyruvate Kinase
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages .
|
-
- HY-B0146R
-
|
CL 318952 (Standard)
|
Reference Standards
YAP
Apoptosis
Autophagy
|
Cancer
|
|
Verteporfin (Standard) is the analytical standard of Verteporfin. This product is intended for research and analytical applications. Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis . Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation .
|
-
- HY-W424779R
-
|
|
Reference Standards
Drug Metabolite
|
Infection
|
|
5-Carboxy-2′-deoxyuridine (Standard) is the analytical standard of 5-Carboxy-2′-deoxyuridine. This product is intended for research and analytical applications. 5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine . 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine .
|
-
- HY-Y1129R
-
|
|
Photosensitizer
Reference Standards
Apoptosis
|
Inflammation/Immunology
|
|
3-Hydroxypyridine (Standard) is the analytical standard of 3-Hydroxypyridine (HY-Y1129). This product is intended for research and analytical applications. 3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .
|
-
- HY-169434
-
|
Lon-TK-BMS-1
|
PD-1/PD-L1
|
Cancer
|
|
LTB is a prodrug formed by coupling glycolysis inhibitor (Lonidamine (HY-B0486)) with PD1/PDL1 blocker (BMS-1 (HY-19991)) by thioketal linkage. LTB can further encapsulate photosensitizer chlorine e6 (Ce6) (HY-13594) to construct a co-delivery photodynamic nanoplatform (LTB-6 NPs) by self-assembly .
|
-
- HY-D2189
-
|
IR 700DX NHS ester
|
Fluorescent Dye
|
Others
|
|
IR 700DX (IR 700DX NHS ester) is a near-infrared (NIR) phthalocyanine dye with extremely high photostability and fluorescence intensity. IR 700DX binds to biomolecules. IR 700DX has excellent water solubility, large extinction coefficient, high fluorescence quantum yield, and does not aggregate in high ionic strength buffers. IR 700DX can be used as a highly flexible photosensitizer .
|
-
- HY-W072530
-
|
|
Fluorescent Dye
|
Others
|
|
[Ir (ppy)2 (bpy)]PF6 is a cyclometalated iridium (III) photosensitizer. [Ir (ppy)2 (bpy)]PF6 can be used in homogeneous photocatalytic systems to achieve visible light-induced water splitting for hydrogen production. [Ir (ppy)2 (bpy)]PF6 functions in homogeneous photocatalytic systems for visible light-driven water splitting to produce hydrogen .
|
-
![[Ir(ppy)2(bpy)]PF6](//file.medchemexpress.com/product_pic/hy-w072530.gif)
- HY-N2575
-
|
|
PKC
Bacterial
Parasite
HIV
VSV
VEGFR
Bcl-2 Family
Apoptosis
|
Infection
Metabolic Disease
Cancer
|
|
Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC50=0.27 μg/ml) .
|
-
- HY-W090294
-
|
Peri-dinaphthalene (purified by sublimation)
|
Environmental Pollutants
Biochemical Assay Reagents
|
Others
|
|
Perylene, which is a polycyclic aromatic hydrocarbon composed of four linearly fused benzene rings, is commonly used as a pigment and dye in a variety of applications, including printing inks, plastics, and textiles. In addition, Perylene has potential uses in solar cells as photosensitizers and as fluorescent probes in biochemistry and materials science. Perylene's rigid planar structure endows it with unique electronic and optical properties, making it a versatile and important compound in many fields of chemistry and materials science.
|
-
- HY-Y0546
-
|
|
Environmental Pollutants
Endogenous Metabolite
Photosensitizer
|
Cancer
|
|
Benzophenone is an endogenous metabolite. Benzophenone is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone exhibits estrogenic activity .
|
-
- HY-128973R
-
|
|
Reactive Oxygen Species (ROS)
Reference Standards
|
Cancer
|
|
Pyropheophorbide-a (Standard) is the analytical standard of Pyropheophorbide-a. This product is intended for research and analytical applications. Pyropheophorbide-a (Ppa) is a photosensitizer used in photodynamic therapy (PDT) for tumors. Pyropheophorbide-a exhibits phototoxic effects on tumor cells, such as cervical cancer cells, and also has anti-lipogenesis activity. Pyropheophorbide-a shows potential for research in the fields of cancer and age-related macular degeneration (AMD). Pyropheophorbide-a derivatives also demonstrate inhibitory activity against tumor cells .
|
-
- HY-149801A
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen?photosensitizer?for simultaneous dual applications of?Gram-positive bacteria (G+)?detection. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+)?from other bacteria due to its interaction with?lipoteichoic acids?(LTA). Antibacterial agent 140 chloride ?also possessed robust?antibacterial activity?for?G+ under?light irradiation .
|
-
- HY-W008566
-
|
Norharman; β-Carboline
|
Monoamine Oxidase
Endogenous Metabolite
|
Infection
Neurological Disease
Cancer
|
|
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
|
-
- HY-DY1092
-
|
Ce6 (solution)
|
Caspase
Apoptosis
Fluorescent Dye
PARP
Bcl-2 Family
|
Cancer
|
Chlorin e6 (solution) (Ce6 (solution)) is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer .
Solvent and concentration: DMSO: 10 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
|
-
- HY-176726
-
|
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
ZnPc-amide-PEG3-C2-NH2 is a photosensitizer-linker conjugate which consists of ZnPcPs (HY-176725) and a linker (HY-W040165). ZnPc-amide-PEG3-C2-NH2 can be used to synthesize the photo-activated BRD4 degrader pZnPc-O3-JQ1 (HY-176724) .
|
-
- HY-161668
-
|
|
Ligands for E3 Ligase
Ferroptosis
|
Cancer
|
|
Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively .
|
-
- HY-W011577S1
-
|
2,3-Benzotriphenylene-13C6
|
Isotope-Labeled Compounds
Photosensitizer
|
Cancer
|
|
Dibenzo[a,c]anthracene- 13C6 (2,3-Benzotriphenylene- 13C6) is 13C labeled Benzo[f]tetraphene. Benzo[f]tetraphene (Dibenz[a,c]anthracene) is a polycyclic aromatic hydrocarbon with significant antitumor activity. Benzo[f]tetraphene is used as a luminescent probe in cell biology research and can effectively detect reactive oxygen species in biological systems. Benzo[f]tetraphene can also be used as a potential photosensitizer and shows good application prospects in photodynamic inhibition.
|
-
![Dibenzo[a,c]anthracene-13C6](//file.medchemexpress.com/product_pic/hy-w011577s1.gif)
- HY-N0005
-
-
- HY-N2552R
-
|
|
Reference Standards
Pyruvate Kinase
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Vitamin K5 (hydrochloride) (Standard) is the analytical standard of Vitamin K5 (hydrochloride). This product is intended for research and analytical applications. Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages[1][2][3].
|
-
- HY-Y0546S2
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Photosensitizer
|
Cancer
|
|
Benzophenone- 13C is the 13C labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite. Benzophenone is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone exhibits estrogenic activity .
|
-
- HY-N2575R
-
|
|
Reference Standards
PKC
Bacterial
Parasite
HIV
VSV
VEGFR
Bcl-2 Family
Apoptosis
|
Infection
Metabolic Disease
Cancer
|
|
Hypocrellin A (Standard) is the analytical standard of Hypocrellin A. This product is intended for research and analytical applications. Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC50=0.27 μg/ml)[1][2][3][4][5][6][7][8][9].
|
-
- HY-Y0546S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Photosensitizer
|
Cancer
|
|
Benzophenone-d5 is the deuterium labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite. Benzophenone is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone exhibits estrogenic activity .
|
-
- HY-Y0546S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Photosensitizer
|
Cancer
|
|
Benzophenone-d10 is the deuterium labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite. Benzophenone is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone exhibits estrogenic activity .
|
-
- HY-14536
-
|
Basic Blue 9; CI-52015; Methylthioninium chloride
|
Environmental Pollutants
Monoamine Oxidase
Guanylate Cyclase
Microtubule/Tubulin
NO Synthase
|
Infection
Neurological Disease
Cancer
|
|
Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene Blue is a photosensitizer and redox agent. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
|
-
- HY-Y0546R
-
|
|
Reference Standards
Endogenous Metabolite
Photosensitizer
|
Cancer
|
|
Benzophenone (Standard) is the analytical standard of Benzophenone. This product is intended for research and analytical applications. Benzophenone standard is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone standard can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone standard can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone standard exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone standard exhibits estrogenic activity .
|
-
- HY-W700241
-
|
|
Isotope-Labeled Compounds
Monoamine Oxidase
Endogenous Metabolite
|
Infection
Neurological Disease
Cancer
|
|
Norharman-d7 is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
|
-
- HY-180825
-
|
|
Apoptosis
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
Cancer
|
|
Anticancer agent 292 (Compound P4) is a photosensitizer for anti-melanoma. Anticancer agent 292 shows good biocompatibility under dark conditions and, upon illumination, induces apoptosis and partial necrosis in B16-F10 cells by disrupting the lysosomal membrane. Anticancer agent 292 not only directly kills tumor cells through the generation of reactive oxygen species (ROS), but also induces immune-prone cell death (ICD), thereby generating anti-tumor immune effects. Anticancer agent 292 can be used in the research of photodynamic therapy for melanoma .
|
-
- HY-W008566R
-
|
Norharman (Standard); β-Carboline (Standard)
|
Reference Standards
Monoamine Oxidase
Endogenous Metabolite
|
Infection
Neurological Disease
Cancer
|
|
Norharmane (Standard) is the analytical standard of Norharmane. This product is intended for research and analytical applications. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
|
-
- HY-N0005S1
-
-
- HY-N0005R
-
|
Diferuloylmethane (Standard); Natural Yellow 3 (Standard); Turmeric yellow (Standard)
|
Reference Standards
Histone Acetyltransferase
Epigenetic Reader Domain
Keap1-Nrf2
Autophagy
Mitophagy
Influenza Virus
Ferroptosis
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Curcumin (Standard) is the analytical standard of Curcumin (HY-N0005). This product is intended for research and analytical applications. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
|
-
- HY-N0005S
-
-
- HY-158189
-
|
|
Photosensitizer
Reactive Oxygen Species (ROS)
Apoptosis
|
Neurological Disease
Cancer
|
|
TPP-Ce6 is a mitochondria-targeted photosensitizer formed by the ester bond conjugation of chlorophyll e6 (Ce6) with triphenylphosphine (TPP). Under light irradiation or ultrasound exposure, TPP-Ce6 generates reactive oxygen species, induces cell apoptosis, and triggers immunogenic cell death. TPP-Ce6 can serve as a component of carrier-free co-delivery systems, undergo enzyme-induced self-assembly within tumors, and modulate tumor hypoxia. TPP-Ce6 is applicable to research on breast cancer and glioblastoma .
|
-
- HY-W008566S
-
|
Norharman-13; β-Carboline-13C
|
Isotope-Labeled Compounds
|
Cancer
|
|
Norharmane- 13C (Norharman- 13C) is the 13C-labeled Norharmane (HY-W008566). Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
|
-
- HY-W086988
-
|
5-Methylbenzotriazole
|
Biochemical Assay Reagents
|
Others
|
|
5-Methyl-1H-benzotriazole (5-Methylbenzotriazole) is a benzotriazole derivative, and serves as a key building block for ultraviolet absorbers and light stabilizers. 5-Methyl-1H-benzotriazole reduces the photosensitizing ability of nitrate and dissolved organic matter (DOM), enhances the persistence of microorganic pollutants, inhibits the photodegradation of DOM and drug residues, and quenches the triplet excited states of DOM and methotrexate substructures. 5-Methyl-1H-benzotriazole acts as a corrosion inhibitor for copper and copper alloys, and is present in formulations of anti-icing fluids, dishwasher detergents, aircraft deicing fluids and automotive antifreezes .
|
-
- HY-W072496
-
|
|
Photosensitizer
Endogenous Metabolite
|
|
|
10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate is a photocatalyst with the activity of enhancing the efficiency of organic reactions. 10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate is widely used in the synthesis of complex molecules and compounds. 10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate also exhibits excellent performance in photosensitization reactions.
|
-
- HY-N7402
-
|
|
Others
|
Others
|
|
Hexyl hexanoate is a fruit aroma component with potential food and beverage additive activity. Hexyl hexanoate is found in alcoholic beverages and is used to blend fruit flavors. Hexyl hexanoate is present in many fruits, Parmesan cheese, alcoholic beverages, and black tea. Hexyl hexanoate is a volatile component produced as a result of fruit ripening. Toxicity assessments of hexyl hexanoate showed that it is not mutagenic and that exposure is below safety thresholds for repeated dose, reproduction, and local respiratory toxicity. Hexyl hexanoate is also below thresholds in skin sensitization assessments, and for phototoxicity and photosensitization, the results showed that it does not present a relevant risk. Hexyl hexanoate is considered non-persistent, non-bioaccumulative, and non-toxic according to the environmental criteria of the International Fragrance Association .
|
-
- HY-19873
-
|
|
Photosensitizer
|
Cancer
|
|
SL-052 is a hypocrellin-based photosensitizer that has recently shown promising results in clinical and preclinical testing for cancer photodynamic therapy (PDT). SL-052 is encapsulated in biodegradable polylactic-co-glycolic acid (PLGA) polymer nanoparticles optimized using single emulsion solvent evaporation technology. The SL-052-PLGA nanoparticles were more effective in PDT treatment of subcutaneous SCCVII squamous cell carcinoma compared to polyvinylpyrrolidone (PVP)-based and standard liposomal SL-052 formulations. A longer time interval between drug injection and tumor illumination can improve tumor cure rates, and SL-052-PLGA nanoparticles showed the best therapeutic effect among all SL-052 formulations.
|
-
- HY-176724
-
|
|
Epigenetic Reader Domain
Reactive Oxygen Species (ROS)
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
ZnPc-O3-JQ1 is a light-triggered BRD4 degrader. Under illumination, ZnPc-O3-JQ1 generates reactive oxygen species (ROS) that degrades BRD4. The degradation of BRD4 results in downregulation of HIF-1α, thereby counteracting the photodynamic therapy (PDT) resistance induced by tumor hypoxia. ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 consists of three parts: BRD4 ligand (HY-78695); Linker (HY-W040165); Photosensitizer (HY-176725) .
|
-
- HY-N0305
-
|
5-ALA hydrochloride; δ-Aminolevulinic acid hydrochloride; 5-Amino-4-oxopentanoic acid hydrochloride
|
Reactive Oxygen Species (ROS)
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) hydrochloride is an orally active heme precursor. 5-Aminolevulinic acid hydrochloride promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid hydrochloride enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid hydrochloride selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid hydrochloride can be applied to the research of septic shock, melanoma, and cancer radiotherapy .
|
-
- HY-W000450
-
|
5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid
|
Reactive Oxygen Species (ROS)
|
Cardiovascular Disease
Cancer
|
|
5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) is an orally active heme precursor. 5-Aminolevulinic acid promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid can be applied to the research of septic shock, melanoma, and cancer radiotherapy .
|
-
- HY-151486
-
|
|
GLUT
|
Cancer
|
|
GLUT1-IN-1 is a glucose transporter 1 (GLUT1) inhibitor and has a GLUT1-specific inactivation ability. GLUT1-IN-1 exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC50 values of 5.49 μM, 11.14 μM, and 8.73 μM, respectively. GLUT1-IN-1 can be used for the research of photodynamic therapy (PDT) and severals cancer .
|
-
- HY-W010713
-
|
Fimaporfin free base
|
Photosensitizer
|
Cancer
|
|
Meso-tetraphenylchlorin (TPCS2a) is a photosensitizer with poor water solubility, which limits its use in the blood circulation. However, TPCS2a@NPs nanoparticles can be prepared based on polylactic-co-polyethylene glycol acid (PLGA) polymer core loaded with TPCS2. Such nanoparticles can be coated with mesenchymal stem cell-derived plasma membranes (mMSCs) to form mMSC-TPCS2a@NPs, which prolongs blood circulation time and improves tumor targeting ability. Compared with uncoated TPCS2a@NPs, mMSC-TPCS2a@NPs can reduce macrophage uptake by 54% to 70% under different conditions. Both nanoparticle forms are effectively accumulated in MCF7 and MDA-MB-231 breast cancer cells, while uptake in normal breast epithelial cells MCF10A is significantly lower .
|
-
- HY-W051271
-
|
Titanium dioxide
|
Environmental Pollutants
Reactive Oxygen Species (ROS)
Photosensitizer
|
Others
|
|
Titanium(IV) oxide is a photosensitizer and photocatalyst. Titanium(IV) oxide can be used as a pharmaceutical excipient such as a flow aid, coating agent, sunscreen, colorant, etc. Pharmaceutical excipients or pharmaceutical excipients refer to other chemical substances used in the pharmaceutical process other than the drug ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations that can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism and elimination (ADME) process of co-administered drugs. Titanium(IV) oxide can use light energy to generate electron-hole pairs to degrade pollutants. Photons excite electrons in TiO2 to generate active oxygen species (such as ·OH and ·O2 -), thereby oxidizing and mineralizing pollutants such as organic compounds and heavy metals. TiO2 can be used in the research of environmental remediation fields such as water treatment, air purification and self-cleaning materials .
|
-
- HY-169798
-
|
|
Fluorescent Dye
VSV
|
Infection
|
1,9-Dimethylmethylene blue is a photosensitizer, virus inactivator and hemoglobin oxidant derived from methylene blue. When activated, 1,9-Dimethylmethylene blue generates reactive oxygen species including singlet oxygen, and acts as a metachromatic dye. When activated in monomeric or dimeric form, 1,9-Dimethylmethylene blue induces photoinactivation of R17 phage and vesicular stomatitis virus and oxidizes hemoglobin via non-singlet oxygen reactive oxygen species or singlet oxygen-mediated pathways, respectively. The monomeric form, with higher nucleic acid affinity, achieves virus inactivation under specific conditions without forming methemoglobin. 1,9-Dimethylmethylene blue binds to substances such as glycosaminoglycans to produce color changes. Although it is susceptible to interference from non-glycosaminoglycan components in urine, it is still applicable to spectrophotometric analysis for glycosaminoglycan quantification. With these unique photochemical and binding properties, 1,9-Dimethylmethylene blue is widely used in studies of viral infections and related biochemical analyses .
|
-
- HY-181906
-
|
|
PROTACs
Reactive Oxygen Species (ROS)
CDK
|
Cancer
|
|
ZnPc-PEG2-VH032 is a VHL-pathway-dependent photodegradation targeting chimera (PDTAC) and cytotoxic agent. ZnPc-PEG2-VH032 (HY-120217) binds to the VHL ligand domain, and then specifically degrades VHL under light irradiation, a process independent of non-specific ROS-mediated protein damage. ZnPc-PEG2-VH032 uses Zinc phthalocyanine (HY-19204) as a photosensitizer, and generates ROS via type I and type II photodynamic pathways under 680 nm LED irradiation. On one hand, it targets and degrades the bound VHL protein through ROS; on the other hand, it exerts direct photodynamic cytotoxicity. Meanwhile, the degradation of VHL downregulates the phosphorylation level of CDK2/4, induces cell cycle arrest in tumor cells, further enhances the sensitivity of tumor cells to oxidative damage caused by ROS, and achieves a synergistic anti-tumor effect. ZnPc-PEG2-VH032 exerts significant in vivo efficacy in an orthotopic mouse model of non-muscle invasive bladder cancer (NMIBC) .
|
-
-
- HY-14536
-
|
Basic Blue 9; CI-52015; Methylthioninium chloride
|
蛍光色素
|
|
Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene Blue is a photosensitizer and redox agent. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
|
-
- HY-D0259
-
|
Erythrosin extra bluish
|
蛍光色素
|
|
Erythrosine B is an artificial dye widely used in the food and textile industries. Erythrosine B is also a novel photosensitizer which has been used to develop animal models.
|
-
- HY-D2189
-
|
IR 700DX NHS ester
|
蛍光色素
|
|
IR 700DX (IR 700DX NHS ester) is a near-infrared (NIR) phthalocyanine dye with extremely high photostability and fluorescence intensity. IR 700DX binds to biomolecules. IR 700DX has excellent water solubility, large extinction coefficient, high fluorescence quantum yield, and does not aggregate in high ionic strength buffers. IR 700DX can be used as a highly flexible photosensitizer .
|
-
- HY-D2309
-
|
|
蛍光色素
|
|
IRDye700Dx Maleimide is a Photosensitizer. When conjugated with HER2 Affibody and activated by near-infrared light, IRDye700Dx Maleimide induces death in HER2-positive breast cancer cells without causing damage to HER2-negative breast cancer cells .
|
-
- HY-129959
-
|
AlClPc
|
蛍光色素
|
|
Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .
|
-
- HY-D2353
-
|
|
蛍光色素
|
|
Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .
|
-
- HY-D1648
-
|
|
蛍光色素
|
|
8-(2,4,6-Trimethylphenyl)-BODIPY is a highly fluorescent dye, can be used as photosensitizer or synthesize other BODIPY-based photosensitizer (λabs=502 nm, λem=516 nm) (*abs: main absorption maxima) .
|
-
- HY-D1472
-
|
|
蛍光色素
|
|
Azure A eosinate is a dye for hematological and histological applications. Azure A eosinate can be used as new photosensitizer prototypes to determine growth inhibition of Candida albicans .
|
-
- HY-D2620
-
|
|
蛍光色素
|
|
CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LDs). CAR-2 exhibits phototoxicity in breast cancer cells with IC50 of 0.01-0.02 μM. CAR-2 exhibits antitumor efficacy in 4T1 xenograft mouse models .
|
-
- HY-123727
-
|
|
蛍光色素
|
|
Acid blue 120 is an azo dye, which can be utilized in textile dyeing, food and pharmaceutical coloring, photosensitizer, sensor and surface modification .
|
-
- HY-162129
-
|
|
蛍光色素
|
|
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC50 value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .
|
-
- HY-D0259R
-
|
Erythrosin extra bluish (Standard)
|
蛍光色素
|
|
Erythrosine B (Standard) is the analytical standard of Erythrosine B. This product is intended for research and analytical applications. Erythrosine B is an artificial dye widely used in the food and textile industries. Erythrosine B is also a novel photosensitizer which has been used to develop animal models.
|
-
- HY-W127725
-
|
|
蛍光色素
|
|
Thymolphthalexon (tetrasodium) is an organic compound commonly used as a reagent in biochemical assays. It belongs to the family of thioxanthone derivatives and has strong antioxidant properties. Thymolphthalexon has several applications in the study of free radical response, oxidative stress, and aging. In addition, it can be used as a photosensitizer in photodynamic therapy for the improvement of cancer and other diseases.
|
-
- HY-D2986
-
|
|
蛍光色素
|
|
TBD–anchor is a water-soluble, positively charged AIE photosensitizer. TBD–anchor can specifically bind to bacterial membranes and efficiently produce 1O2. TBD–anchor has bactericidal activity against various bacteria and good biocompatibility. TBD–anchor can be used for research on bacterial infections .
|
-
- HY-D2979
-
|
|
蛍光色素
|
|
OBADC-TPA is a new type of photosensitizer. OBADC-TPA is commonly used to modify nanoparticles. OBADC-TPA can be used for precise optical imaging and research of lymphoma .
|
-
- HY-W072530
-
|
|
蛍光色素
|
|
[Ir (ppy)2 (bpy)]PF6 is a cyclometalated iridium (III) photosensitizer. [Ir (ppy)2 (bpy)]PF6 can be used in homogeneous photocatalytic systems to achieve visible light-induced water splitting for hydrogen production. [Ir (ppy)2 (bpy)]PF6 functions in homogeneous photocatalytic systems for visible light-driven water splitting to produce hydrogen .
|
-
- HY-DY1092
-
|
Ce6 (solution)
|
蛍光色素
|
Chlorin e6 (solution) (Ce6 (solution)) is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer .
Solvent and concentration: DMSO: 10 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
|
-
- HY-121310
-
|
|
生化学アッセイ試薬
|
Phthalocyanine is a photosensitizer. Phthalocyanine has a light-killing effect on bacterial biofilms, effectively inactivating bacteria. Phthalocyanine can be linked to anticancer drugs to target cancer. Phthalocyanine can also be used to develop chemical sensors for studying microbial infections and tumors .
|
-
- HY-W090294
-
|
Peri-dinaphthalene (purified by sublimation)
|
生化学アッセイ試薬
|
|
Perylene, which is a polycyclic aromatic hydrocarbon composed of four linearly fused benzene rings, is commonly used as a pigment and dye in a variety of applications, including printing inks, plastics, and textiles. In addition, Perylene has potential uses in solar cells as photosensitizers and as fluorescent probes in biochemistry and materials science. Perylene's rigid planar structure endows it with unique electronic and optical properties, making it a versatile and important compound in many fields of chemistry and materials science.
|
-
- HY-132141
-
|
5-Propargylamino-dUTP
|
生化学アッセイ試薬
|
|
5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W076903
-
|
p-Benzoylaniline; 4-Aminophenyl phenyl ketone; 4-Benzoylaniline
|
生化学アッセイ試薬
|
|
4-Aminobenzophenone (p-Benzoylaniline; 4-Aminophenyl phenyl ketone; 4-Benzoylaniline) is Benzophenone (HY-Y0546) derivative, which behaves as photosensitizer .
|
-
- HY-W011376
-
|
|
生化学アッセイ試薬
|
|
5-Bromo-2'-deoxycytidine is a DNA photosensitizer. 5-Bromo-2'-deoxycytidine modifies the double-stranded DNA, and determinate the DNA damage 300 nm photon .
|
-
- HY-W854659
-
|
Ce6 trisodium
|
生化学アッセイ試薬
|
|
Chlorin e6 Ce6 (trisodium) is a water-soluble derivative of chlorophyll, belonging to the chlorin class of photosensitizers with an absorption wavelength range of 600-670 nm. Chlorin e6 trisodium emits characteristic red fluorescence upon light excitation, enabling real-time identification of tumor boundaries and progression. Chlorin e6 trisodium can be used for the study of photodynamic therapy (PDT) of cancers (bladder cancer) and fluorescence diagnosis of neoplastic lesions .
|
-
- HY-W035051
-
|
|
生化学アッセイ試薬
|
|
TSPP tetrasodium is a photosensitizer that has shown impressive effects in in vivo regression of cancer and microorganism infections (Ex: 413 nm, Em: 640 nm) .
|
-
- HY-W073074
-
|
|
生化学アッセイ試薬
|
Mesoporphyrin IX (dihydrochloride) is a photosensitizer that can be used to modify liposomes. Mesoporphyrin IX (dihydrochloride) can insert into lipid vesicles and disrupt the viral membrane structure in vesicular stomatitis virus (VSV), inducing cross-linking of VSV glycoproteins, thereby inhibiting viral activity .
|
-
- HY-W127809
-
|
|
生化学アッセイ試薬
|
|
Chlorin e4 is an organic compound belonging to the family of chlorins, which are macrocyclic compounds with a similar structure to porphyrins. It is commonly used to improve photodynamic therapy for cancer and other diseases. Chlorin e4 has multiple applications in medical research, including as a photosensitizer for localized tumor destruction. In addition, its antimicrobial properties and potential use in disinfection applications were investigated.
|
-
- HY-W504836
-
|
|
生化学アッセイ試薬
|
Deuteroporphyrin IX (dihydrochloride) is a photosensitizer with high lipophilicity and amphiphilicity, capable of providing photosensitivity for cell membrane systems. Deuteroporphyrin IX (dihydrochloride) can induce irreversible discharge elimination in individual neurons .
|
-
- HY-P2213
-
|
|
MMP
Apoptosis
|
Cancer
|
|
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .
|
-
- HY-P2213A
-
|
|
MMP
Apoptosis
|
Cancer
|
|
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .
|
| 製品番号 |
製品名 |
Target |
研究分野 |
Image |
-
- HY-P99500
-
|
RM-1929; Cetuximab-IRDye-700DX
|
EGFR
|
Cancer
|
|
Cetuximab sarotalocan (RM-1929) is an IRdye700DX (near-infrared photosensitizing dye) conjugate of Cetuximab (anti-EGFR monoclonal antibody). Cetuximab sarotalocan can be used for head and neck cancers research .
|
-
(5)
| 製品番号 |
製品名 |
Category |
Target |
構造式 |
-
- HY-N0005
-
-
-
- HY-N0305
-
|
5-ALA hydrochloride; δ-Aminolevulinic acid hydrochloride; 5-Amino-4-oxopentanoic acid hydrochloride
|
Structural Classification
Classification of Application Fields
Ketones, Aldehydes, Acids
Endogenous metabolite
Disease Research Fields
Cancer
|
Reactive Oxygen Species (ROS)
|
|
5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) hydrochloride is an orally active heme precursor. 5-Aminolevulinic acid hydrochloride promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid hydrochloride enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid hydrochloride selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid hydrochloride can be applied to the research of septic shock, melanoma, and cancer radiotherapy .
|
-
-
- HY-W008566
-
-
-
- HY-W000450
-
-
-
- HY-B0754A
-
-
-
- HY-125665
-
|
|
Microorganisms
Ketones, Aldehydes, Acids
Source Classification
|
Apoptosis
|
|
Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research .
|
-
-
- HY-113011
-
-
-
- HY-Y0546
-
|
|
Structural Classification
Microorganisms
Classification of Application Fields
Ketones, Aldehydes, Acids
Metabolic Disease
Endogenous metabolite
Disease Research Fields
Source Classification
|
Environmental Pollutants
Endogenous Metabolite
Photosensitizer
|
|
Benzophenone is an endogenous metabolite. Benzophenone is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone exhibits estrogenic activity .
|
-
-
- HY-N0005R
-
-
-
- HY-N2575
-
-
-
- HY-B0754
-
-
-
- HY-N1453
-
-
-
- HY-Y1819
-
-
-
- HY-N10902
-
-
-
- HY-N6743
-
-
-
- HY-Y1129
-
-
-
- HY-W013521
-
-
-
- HY-137474
-
-
-
- HY-N16417
-
-
-
- HY-N10611
-
-
-
- HY-113011R
-
-
-
- HY-N7402
-
|
|
天然物
Animals
Source Classification
|
Others
|
|
Hexyl hexanoate is a fruit aroma component with potential food and beverage additive activity. Hexyl hexanoate is found in alcoholic beverages and is used to blend fruit flavors. Hexyl hexanoate is present in many fruits, Parmesan cheese, alcoholic beverages, and black tea. Hexyl hexanoate is a volatile component produced as a result of fruit ripening. Toxicity assessments of hexyl hexanoate showed that it is not mutagenic and that exposure is below safety thresholds for repeated dose, reproduction, and local respiratory toxicity. Hexyl hexanoate is also below thresholds in skin sensitization assessments, and for phototoxicity and photosensitization, the results showed that it does not present a relevant risk. Hexyl hexanoate is considered non-persistent, non-bioaccumulative, and non-toxic according to the environmental criteria of the International Fragrance Association .
|
-
-
- HY-126841
-
|
|
Microorganisms
Phenols
Source Classification
|
Photosensitizer
|
|
5-Methoxysterigmatocystin is a mycotoxin with cytotoxic and genotoxic properties. 5-Methoxysterigmatocystin exhibits cytotoxicity against cancer cells A549 and HepG2 (IC50 of 5.5 and 0.7 μM), and induces DNA damage. 5-Methoxysterigmatocystin is a photosensitizer, which utilizes the visible to generate singlet oxygen ( 1O2) .
|
-
-
- HY-Y1819R
-
-
-
- HY-N1453R
-
-
-
- HY-Y1129R
-
-
-
- HY-N2575R
-
-
-
- HY-Y0546R
-
|
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Endogenous metabolite
Source Classification
|
Reference Standards
Endogenous Metabolite
Photosensitizer
|
|
Benzophenone (Standard) is the analytical standard of Benzophenone. This product is intended for research and analytical applications. Benzophenone standard is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone standard can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone standard can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone standard exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone standard exhibits estrogenic activity .
|
-
-
- HY-W008566R
-
-
-
- HY-N12630
-
|
Mycosporine-Gly
|
Structural Classification
Animals
Ketones, Aldehydes, Acids
Source Classification
|
Mitochondrial Metabolism
Bacterial
|
|
Mycosporine glycine (Mycosporine-Gly) is a potent singlet oxygen quencher. Mycosporine glycine can effectively suppress various detrimental effects of the Type-II photosensitization in biological systems, such as inactivation of mitochondrial electron transport, lipid peroxidation of microsomes, hemolysis of erythrocytes and growth inhibition of E.coli. Mycosporine glycine can be used for protecting marine organisms against sunlight damage .
|
-
-
- HY-N0005S
-
|
|
|
Curcumin-d6 (Diferuloylmethane-d6 ) is deuterium labeled Curcumin (HY-N0005). Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
|
-
-
- HY-Y0546S
-
|
|
|
Benzophenone-d10 is the deuterium labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite. Benzophenone is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone exhibits estrogenic activity .
|
-
-
- HY-Y0546S2
-
|
|
|
Benzophenone- 13C is the 13C labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite. Benzophenone is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone exhibits estrogenic activity .
|
-
-
- HY-N0005S1
-
|
|
|
Curcumin-d3 (Diferuloylmethane-d3 ) is deuterium labeled Curcumin (HY-N0005). Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
|
-
-
- HY-Y1129S
-
|
|
|
3-Hydroxypyridine-d4 is the deuterium labeled 3-Hydroxypyridine (HY-Y1129). 3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .
|
-
-
- HY-W011577S1
-
|
|
|
Dibenzo[a,c]anthracene- 13C6 (2,3-Benzotriphenylene- 13C6) is 13C labeled Benzo[f]tetraphene. Benzo[f]tetraphene (Dibenz[a,c]anthracene) is a polycyclic aromatic hydrocarbon with significant antitumor activity. Benzo[f]tetraphene is used as a luminescent probe in cell biology research and can effectively detect reactive oxygen species in biological systems. Benzo[f]tetraphene can also be used as a potential photosensitizer and shows good application prospects in photodynamic inhibition.
|
-
-
- HY-Y0546S1
-
|
|
|
Benzophenone-d5 is the deuterium labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite. Benzophenone is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone exhibits estrogenic activity .
|
-
-
- HY-W700241
-
|
|
|
Norharman-d7 is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
|
-
-
- HY-W746295
-
|
|
|
3-Hydroxypyridine-d5 is the deuterium labeled 3-Hydroxypyridine (HY-Y1129). 3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .
|
-
-
- HY-W008566S
-
|
|
|
Norharmane- 13C (Norharman- 13C) is the 13C-labeled Norharmane (HY-W008566). Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
|
-
-
- HY-139286
-
|
Pacsph; Pacsphingosine (d18:1)
|
|
Alkynes
|
|
Photoclick sphingosine (Pacsph) is a photosensitizing and clickable sphingosine analog. Photoclick sphingosine is metabolized in cells into endogenous lipid metabolic pathways and can be visualized by its clickable alkyne group. Photoclick sphingosine can be used to study intracellular sphingolipid metabolism and subcellular localization .
|
-
- HY-162129
-
|
|
|
Azide
|
|
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC50 value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .
|
-
- HY-132141
-
|
5-Propargylamino-dUTP
|
|
Nucleotide Analogs
|
|
5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W011376
-
|
|
|
Nucleoside Analogs
Cytidine
|
|
5-Bromo-2'-deoxycytidine is a DNA photosensitizer. 5-Bromo-2'-deoxycytidine modifies the double-stranded DNA, and determinate the DNA damage 300 nm photon .
|
-
- HY-W424779
-
|
|
|
Nucleoside Analogs
Uridine
|
|
5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine . 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine .
|
-
- HY-185390
-
|
Liposomal verteporfin
|
|
Liposome
|
|
Verteporfin liposome is a liposome-encapsulated form of Verteporfin (HY-B0146). Verteporfin is a photosensitizer used in photodynamic therapy to eliminate abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin liposome prolongs drug circulation time and provides slow release, allowing the drug to accumulate in newly formed blood vessels.
|
入力情報は安全に管理されます. ※ 必須入力項目.
Inquiry Information
- 製品名:
- 製品番号:
- 数量:
- MCE 日本正規代理店:
![[Ru(DIP)2TAP]Cl2](http://file.medchemexpress.com/product_pic/hy-157051.gif)
2](http://file.medchemexpress.com/product_pic/hy-157053.gif)
![Benzo[f]tetraphene](http://file.medchemexpress.com/product_pic/hy-w011577.gif)
![[Ir(ppy)2(bpy)]PF6](http://file.medchemexpress.com/product_pic/hy-w072530.gif)
![Dibenzo[a,c]anthracene-13C6](http://file.medchemexpress.com/product_pic/hy-w011577s1.gif)
