2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Temoporfin

Temoporfin  (Synonyms: m-THPC; KW2345)

Cat. No.: HY-16488 Purity: 97.29%
COA Handling Instructions

Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers.

For research use only. We do not sell to patients.

Temoporfin Chemical Structure

Temoporfin Chemical Structure

CAS No. : 122341-38-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 198 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 198 In-stock
Solid
5 mg USD 132 In-stock
10 mg USD 228 In-stock
25 mg USD 468 In-stock
50 mg USD 828 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 8 publication(s) in Google Scholar

Temoporfin Related Antibodies

Top Publications Citing Use of Products

    Temoporfin purchased from MCE. Usage Cited in: Theranostics. 2018 Feb 4;8(5):1435-1448.  [Abstract]

    In vivo fluorescence images of glioma-bearing mice intravenously receiving different mTHPC-containing formulations.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers[1][2][3].

    In Vitro

    A detailed confocal fluorescence microscopy study of a human adenocarcinoma shows weak localization of Temoporfin in lysosomes and mitochondria. Instead, it is found to be localized in the endoplasmic reticulum (ER) and the Golgi apparatus[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Temoporfin Related Antibodies
    In Vivo

    Temoporfin in liver tissue decreases rapidly in time after initial high levels at 4 h after administration (0.1-0.3 mg/kg). In tumour tissue no decrease in photosensitizer levels occurred, with Temoporfin remaining high up to 48 h after administration[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    680.75

    Appearance

    Solid

    Formula

    C44H32N4O4
    CAS No.
    SMILES

    OC1=CC=CC(/C2=C3CCC(/C(C4=CC(O)=CC=C4)=C5C=C/C(N/5)=C(C6=CC(O)=CC=C6)/C(C=C/7)=NC7=C(C8=CC(O)=CC=C8)/C9=CC=C2N9)=N\3)=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
    Solvent & Solubility
    In Vitro: 

    DMSO : 20.83 mg/mL (30.60 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4690 mL 7.3448 mL 14.6897 mL
    5 mM 0.2938 mL 1.4690 mL 2.9379 mL
    10 mM 0.1469 mL 0.7345 mL 1.4690 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 1 mg/mL (1.47 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 1 mg/mL (1.47 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 97.29%

    COA (261 KB) LCMS (260 KB)

    Handling Instructions (2659 KB)
    References
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    • If you have published this work, please enter the PubMed ID.
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    Temoporfin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Temoporfin122341-38-2m-THPC KW2345KW2345KW 2345KW-2345Reactive Oxygen Speciesreduced porphyrinphotosensitizerphotodynamic therapyPDThead and neck cancerInhibitorinhibitorinhibit

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