Chlorin e6 trisodium
Based on 20 publication(s) in Google Scholar
Chlorin e6 Ce6 (trisodium) is a water-soluble derivative of chlorophyll, belonging to the chlorin class of photosensitizers with an absorption wavelength range of 600-670 nm. Chlorin e6 trisodium emits characteristic red fluorescence upon light excitation, enabling real-time identification of tumor boundaries and progression. Chlorin e6 trisodium can be used for the study of photodynamic therapy (PDT) of cancers (bladder cancer) and fluorescence diagnosis of neoplastic lesions.
For research use only. We do not sell to patients.
- Purity: 98.92%
- CAS No.: 72984-36-2
- Formula: C34H33N4Na3O6
- Molecular Weight:662.62
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Chlorin e6 trisodium
More- ACS Nano. 2025 Apr 25. [Abstract]
- Acta Pharm Sin B. 2026 Apr 24.
- Adv Sci (Weinh). 2025 Nov 21:e10500. [Abstract]
- Adv Sci (Weinh). 2025 Oct 27:e10854. [Abstract]
- Adv Sci (Weinh). 2024 May;11(19):e2306684. [Abstract]
- Chem Eng J. 2024 Nov 15.
- Biomaterials. 2025 Dec 24:329:123948. [Abstract]
- Sci Adv. 2026 Jan 2;12(1):eady1030. [Abstract]
- J Control Release. 2026 Apr 10:392:114698. [Abstract]
- J Control Release. 2023 May:357:460-471. [Abstract]
- Cell Rep Med. 2025 Jul 15;6(7):102239. [Abstract]
- Acta Biomater. 2026 Apr:214:527-541. [Abstract]
- Acta Biomater. 2023 Jul 1:164:407-421. [Abstract]
- ACS Appl Mater Interfaces. 2025 Dec 31. [Abstract]
- ACS Appl Mater Interfaces. 2025 Aug 20;17(33):46680-46692. [Abstract]
- Int J Pharm X. 2026 Apr 7:11:100537. [Abstract]
- Eur J Med Chem. 2024 Jan 15:264:115975. [Abstract]
- ACS Appl Bio Mater. 2023 Jul 17;6(7):2816-2825. [Abstract]
- ChemMedChem. 2026 Jan;21(2):e202500617. [Abstract]
- Photodiagnosis Photodyn Ther. 2024 Aug 22:104319. [Abstract]
Biological Activity
Chlorin e6 trisodium (24 h incubation followed by irradiation) shows dark cytotoxicity in HeLa cells with an IC50 of 13 μM and phototoxicity with an IC50 of 0.83 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MGH cells (3.0 × 106) were subcutaneously implanted into the lower flanks of 6-8-week-old male BALB/c nude mice[1]
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Dosage:2.5, 3.5, 5 mg/kg combined with laser irradiation
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Administration:i.v., single dose
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Result:Achieved tumor growth inhibition.
Chemical Information
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CAS No. 72984-36-2
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Appearance Solid
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Molecular Weight 662.62
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Formula C34H33N4Na3O6
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Color Brown to black
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SMILES
O=C(O[Na])C/C1=C2[C@H]([C@@H](C(/C=C3N/C(C(C=C)=C\3C)=C\C4=N/C(C(CC)=C4C)=C\C5=C(C)C(C(O[Na])=O)=C1N5)=N\2)C)CCC(O[Na])=O
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Synonyms
Ce6 trisodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (20)
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Journal Impact Factor
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Most Recent
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ACS Nano
Amplifying X-ray-Induced Charge Transfer Facilitates Direct Sensitization of Photosensitizers in Radiotherapy. [Abstract]2025 Apr 25. PMID: 40277128 -
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Adv Sci (Weinh)
Targeting the SOX9/TIMP1 Axis with iRGD-Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer. [Abstract]2025 Nov 21:e10500. PMID: 41270217 -
Adv Sci (Weinh)
Reprogramming Tumor-Associated Macrophages via Targeted NAT10 Inhibition to Enhance Colorectal Cancer Immunotherapy. [Abstract]2025 Oct 27:e10854. PMID: 41144699 -
Adv Sci (Weinh)
Cold-Responsive Hyaluronated Upconversion Nanoplatform for Transdermal Cryo-Photodynamic Cancer Therapy. [Abstract]2024 May;11(19):e2306684. PMID: 38482992 -
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Biomaterials
Long-acting multiple programmed cell death nanoinducers based on polyunsaturated fatty acid supplemented liposomal photosensitizers for enhanced photodynamic immunotherapy. [Abstract]2025 Dec 24:329:123948. PMID: 41455306 -
Sci Adv
A softness zwitterionic micelles efficiently deliver inhaled nintedanib by enhancing airway mucus penetration. [Abstract]2026 Jan 2;12(1):eady1030. PMID: 41481743 -
J Control Release
Immunosuppressive-responsive hydrogel for self-regulated drug release and tumor microenvironment reprogramming. [Abstract]2026 Apr 10:392:114698. PMID: 41692045 -
J Control Release
Targeting glutamine metabolism with photodynamic immunotherapy for metastatic tumor eradication. [Abstract]2023 May:357:460-471. PMID: 37068523 -
Cell Rep Med
Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma. [Abstract]2025 Jul 15;6(7):102239. PMID: 40669448 -
Acta Biomater
Fluorinated polymeric nanoplatform relieves tumor hypoxia and enhances chemo-sonodynamic therapy. [Abstract]2026 Apr:214:527-541. PMID: 41796925 -
Acta Biomater
A Supramolecular Assembly Strategy for Hydrophilic Drug Delivery towards Synergistic Cancer Treatment. [Abstract]2023 Jul 1:164:407-421. PMID: 37088157 -
ACS Appl Mater Interfaces
Mitochondrial Rapid Accumulation and Self-Enhanced Penetrating Nanomedicine for Tumor Multi-role Treatment. [Abstract]2025 Dec 31. PMID: 41476371 -
ACS Appl Mater Interfaces
Platelet Membrane Biomimetic Chemiluminescent Nanoparticles for Targeted Therapy of Atherosclerosis. [Abstract]2025 Aug 20;17(33):46680-46692. PMID: 40785258 -
Int J Pharm X
Biomineralized outer membrane vesicles for synergistic immuno-photodynamic therapy of oral squamous cell carcinoma. [Abstract]2026 Apr 7:11:100537. PMID: 42028058 -
Eur J Med Chem
Mitochondria-targeted pentacyclic triterpene NIR-AIE derivatives for enhanced chemotherapeutic and chemo-photodynamic combined therapy. [Abstract]2024 Jan 15:264:115975. PMID: 38039788 -
ACS Appl Bio Mater
Feedback-Elevated Antitumor Amplifier of Self-Delivery Nanomedicine by Suppressing Photodynamic Therapy-Caused Inflammation. [Abstract]2023 Jul 17;6(7):2816-2825. PMID: 37326439 -
ChemMedChem
Polydopamine-Based Light Responsive Nanoparticles with Magnetic Resonance Imaging Capabilities for Breast Cancer Photodynamic/Photothermal Therapy Combination Therapy. [Abstract]2026 Jan;21(2):e202500617. PMID: 41619218 -
Photodiagnosis Photodyn Ther
Regorafenib enhances the efficacy of photodynamic therapy in hepatocellular carcinoma through MAPK signaling pathway suppression. [Abstract]2024 Aug 22:104319. PMID: 39181490
Solvent & Solubility
DMSO : 5 mg/mL (7.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (7.55 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Chin WW, et al. The potential application of chlorin e6-polyvinylpyrrolidone formulation in photodynamic therapy. Photochem Photobiol Sci. 2006 Nov;5(11):1031-7. [Content Brief]
[2]. Chin WW, et al. Fluorescence imaging and phototoxicity effects of new formulation of chlorin e6-polyvinylpyrrolidone. J Photochem Photobiol B. 2006 Aug 1;84(2):103-10. [Content Brief]
[3]. Rybkin AY, et al. Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity. Pharmaceutics. 2023 Jan 12;15(1):273. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.5092 mL | 7.5458 mL | 15.0916 mL | 37.7290 mL |
| 5 mM | 0.3018 mL | 1.5092 mL | 3.0183 mL | 7.5458 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Chlorin e6 trisodium Related Classifications
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