24533-72-0
Chemical Structure
Pyropheophorbide-a
- CAS No.: 24533-72-0
- Formula:C33H34N4O3
- Molecular Weight:534.65
InChIKey: IEGUQQKIFBYXLG-CDIXLCFRSA-N
SMILES: CC1=C2C(N/C1=C\3)=C(CC2=O)C([C@H]4CCC(O)=O)=N/C([C@H]4C)=C\C5=C(C)C(C=C)=C(N5)/C=C6C(C)=C(CC)C3=N/6
Biological Activity: Pyropheophorbide-a (Ppa) is a photosensitizer used in photodynamic therapy (PDT) for tumors. Pyropheophorbide-a exhibits phototoxic effects on tumor cells, such as cervical cancer cells, and also has anti-lipogenesis activity. Pyropheophorbide-a shows potential for research in the fields of cancer and age-related macular degeneration (AMD). Pyropheophorbide-a derivatives also demonstrate inhibitory activity against tumor cells[1][2][3][4].
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Pyropheophorbide-a | 98.0% | Pyropheophorbide-a (Ppa) is a photosensitizer used in photodynamic therapy (PDT) for tumors. Pyropheophorbide-a exhibits phototoxic effects on tumor cells, such as cervical cancer cells, and also has anti-lipogenesis activity. Pyropheophorbide-a shows potential for research in the fields of cancer and age-related macular degeneration (AMD). Pyropheophorbide-a derivatives also demonstrate inhibitory activity against tumor cells. | ||||||||||||||||||||
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Pyropheophorbide-a (Standard) | ≥98% | Pyropheophorbide-a (Standard) is the analytical standard of Pyropheophorbide-a. This product is intended for research and analytical applications. Pyropheophorbide-a (Ppa) is a photosensitizer used in photodynamic therapy (PDT) for tumors. Pyropheophorbide-a exhibits phototoxic effects on tumor cells, such as cervical cancer cells, and also has anti-lipogenesis activity. Pyropheophorbide-a shows potential for research in the fields of cancer and age-related macular degeneration (AMD). Pyropheophorbide-a derivatives also demonstrate inhibitory activity against tumor cells. | ||||||||||||||||||||
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References
- [1]. Li W, et al. cRGD Peptide-Conjugated Pyropheophorbide-a Photosensitizers for Tumor Targeting in Photodynamic Therapy. Mol Pharm. 2018 Apr 2;15(4):1505-1514. [Content Brief]
- [2]. Liu YH, et al. Anti-adipogenic activities of pheophorbide a and pyropheophorbide a isolated from wild bitter gourd (Momordica charantia L. var. abbreviata Seringe) in vitro. J Sci Food Agric. 2022 Nov;102(14):6771-6779. [Content Brief]
- [3]. Bao L L, et al. In vitro and in vivo evaluation of a pyropheophorbide-a derivative as a potential photosensitizer for age-related macular degeneration[J]. Biomedicine & Pharmacotherapy, 2017, 88: 1220-1226.
- [4]. Chaturvedi P K, et al. Phototoxic effects of pyropheophorbide-a from chlorophyll-a on cervical cancer cells[J]. Journal of Porphyrins and Phthalocyanines, 2014, 18(03): 182-187.
