10-Hydroxypheophorbide A
10-Hydroxypheophorbide A is a chlorophyll-related compound found in the leaves of
Neptunia oieracea. 10-Hydroxypheophorbide A inhibits the activation of tumor promoter-induced Epstein-Barr virus (EBV) activation. 10-Hydroxypheophorbide A exhibits photo-induced cytotoxicity in cancer cells.
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- CAS No.: 83688-53-3
- Formule: C35H36N4O6
- Masse moléculaire:608.68
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Stockage:
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 1A9 | ED50 |
1.2 μg/mL
Compound: 3
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Cytotoxicity against human 1A9 cells after 72 hrs by SRB assay
Cytotoxicity against human 1A9 cells after 72 hrs by SRB assay
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[PMID: 11473423] |
In Vitro
10-Hydroxypheophorbide A (Compound 6) (0.05-50 μM) inhibits teleocidin B-4-induced EBV activation in Raji cells with an IC50 of 18 μM, with increasing inhibitory activity observed at concentrations from 0.05 μM to 50 μM[1].
10-Hydroxypheophorbide A exhibits photocytotoxicity in Raji cells, with a pLC50 of 4.92 without irradiation and a pLC50 of 7.06 with irradiation, indicating increased cytotoxicity with photo-exposure[1].
10-Hydroxypheophorbide A (50 μM; 30 h) accelerates photo-induced ethyl linoleate peroxidation in a cell-free system, resulting in an OD532 value of 0.426 at 50 μM after 30 h of irradiation[1].
10-Hydroxypheophorbide A (0.5 μM) does not have its inhibitory activity against EBV activation in Raji cells significantly enhanced by photo-irradiation, with 0 ± 3% inhibition without irradiation and 2 ± 8% inhibition with irradiation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 83688-53-3
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Masse moléculaire 608.68
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Formule C35H36N4O6
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SMILES
COC([C@@]1(/C2=C([C@H]([C@@H]3C)CCC(O)=O)/N=C3/C=C(C(C)=C/4C=C)\NC4=C/C5=N/C(C(CC)=C5C)=C\C6=C(C)C(C1=O)=C2N6)O)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
10-Hydroxypheophorbide A Related Classifications
HY-N17999 Related Classifications
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