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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
positive inotropic agent
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "positive inotropic agent" in MCE Product Catalog:
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Milrinone lactate is a potent inotropic dilating agent. Milrinone lactate shows simultaneous positive inotropic and vasodilating activities. Milrinone lactate promotes reduction of SVR and PVR in patients with DCM and NYHA class III and IV of heart failure. Milrinone lactate has the potential for the research of cardiovascular function after cardiac surgery and in septic shock .
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DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect .
Cat. No.: HY-B1294
CAS No.: 60719-84-8
Synonyms: Inamrinone
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Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .
Cat. No.: HY-165439
CAS No.: 100643-96-7
Synonyms: LY195115
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Indolidan (LY195115) is an orally active cardiotonic agent and a selective cyclic nucleotide phosphodiesterase inhibitor. Indolidan has a Ki of 80 nM for sarcoplasmic reticulum phosphodiesterase (SR-PDE). Indolidan exhibits positive inotropic and vasodilator effects. Indolidan can be used in the research of diseases such as congestive heart failure .
Cat. No.: HY-W017764
CAS No.: 15450-69-8
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7,8-Dihydro-2,5(1H,6H)-quinolinedione (compound SF32) is a positive inotropic agent .
Cat. No.: HY-167079
CAS No.: 128667-63-0
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OPC-18750 is a novel positive inotropic agent and 2(lH)-quinolinone derivative. OPC-18750 displays positive inotropic and coronary vasodilating effects .
Cat. No.: HY-113547
CAS No.: 102791-47-9
Synonyms: UK 61260
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Nanterinone (UK 61260) is a positive inotropic and arterial vasodilating agent. Nanterinone is a phosphodiesterase inhibitor .
Cat. No.: HY-113847
CAS No.: 102791-74-2
Synonyms: UK-61260-27
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Nanterinone mesylate (UK-61260-27) is an orally active and positive inotropic and balanced-type vasodilating agent, partially based on phosphodiesterase III inhibition with venodilating properties. Nanterinone mesylate is promising for research of cardiovascular diseases .
Cat. No.: HY-16256
CAS No.: 75898-90-7
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Amrinone lactate is a positive inotropic-vasodilator agent. Amrinone lactate is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone lactate is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .
Cat. No.: HY-B1294R
CAS No.: 60719-84-8
Synonyms: Inamrinone (Standard)
Research Areas:
Amrinone (Standard) is the analytical standard of Amrinone. This product is intended for research and analytical applications. Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .
Cat. No.: HY-117715
CAS No.: 132523-92-3
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CK-3197 is a weak inhibitor of Peak lll cyclic 3'5'-adenosine monophosphate phosphodiesterase
(CAMP PDEl). CK-3197 has hemodynamic and myocardial energetic effects in vivo. CK-3197 is an imidazolone derivative used as a selective positive inotropic agent for congestive heart failure .
Cat. No.: HY-19666R
CAS No.: 97730-95-5
Synonyms: SDZ 201106 (Standard)
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DPI 201-106 (Standard) is the analytical standard of DPI 201-106. This product is intended for research and analytical applications. DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect .
Cat. No.: HY-W748419
CAS No.: 60-38-8
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Cat. No.: HY-19088
CAS No.: 114856-44-9
Synonyms: CID-3047798
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Oberadilol (CID-3047798) is a Phosphodiesterase III inhibitor, non-selective β-adrenergic receptor blocker, vasodilator and positive inotropic agent. Oberadilol reduces left ventricular end-diastolic volume. Oberadilol is used in research related to chronic congestive heart failure and SARS-CoV-2 infection .
Cat. No.: HY-19088A
CAS No.: 114856-47-2
Synonyms: CID-3047798 (monoethyl maleate); TZC 5665
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Oberadilol monoethyl maleate (CID-3047798 monoethyl maleate) is a Phosphodiesterase III inhibitor, non-selective β-adrenergic receptor blocker, vasodilator and positive inotropic agent. Oberadilol monoethyl maleate reduces left ventricular end-diastolic volume. Oberadilol monoethyl maleate is used in research related to chronic congestive heart failure and SARS-CoV-2 infection .
Cat. No.: HY-106830
CAS No.: 94386-65-9
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Pelrinone is an orally active cardiotonic agent and PDE III inhibitor with an IC50 of 36 μM. Pelrinone elevates intracellular cAMP levels. The action of Pelrinone is independent of β-adrenergic receptors, and it does not inhibit Na +/K +-ATPase. Pelrinone exerts positive inotropic and vasodilatory effects. Pelrinone inhibits platelet aggregation, reduces thrombus formation, and exerts weak anticoagulant activity without altering hematocrit or circulating platelet counts. Pelrinone can be used in research related to congestive heart failure and coronary thrombosis .
Cat. No.: HY-165486
CAS No.: 108610-89-5
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AWD 122-60 is a potassium channel blocker and calcium sensitizer, with IC50 values of 11 μM and 29 μM, respectively, against mouse skeletal muscle ATP-sensitive potassium (KATP) channels. AWD 122-60 exerts potent positive inotropic activity. AWD 122-60 exhibits antiarrhythmic activity in vivo and prolongs myocardial refractory period in vitro. AWD 122-60 can be used for research related to arrhythmias .
Cat. No.: HY-19091
CAS No.: 123297-52-9
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ICI-170777 is an orally active cardiotonic agent and type III Phosphodiesterase inhibitor, with an IC50 of 2.5 μM against cyclic AMP phosphodiesterase type III from canine cardiac fractions. ICI-170777 inhibits Aldrin epoxidase and pentobarbital metabolism. It enhances β-adrenergic receptor-mediated positive inotropic effects without causing chronotropic effects, while also exerting balanced arteriolar/venular vasodilator, platelet aggregation inhibitor and smooth muscle relaxant activities. ICI-170777 restores cardiac function in an acute canine heart failure model, exhibits additive effects when combined with Ouabain (HY-B1457), and shows no significant activity against multiple receptor classes or non-cardiac systems. ICI-170777 can be used in research related to congestive heart failure .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
