100643-96-7
100643-96-7
Chemical Structure
Indolidan
Synonym(s): LY195115
- CAS No.: 100643-96-7
- Formula:C14H15N3O2
- Molecular Weight:257.29
InChIKey: LZCQFJKUAIWHRW-UHFFFAOYSA-N
SMILES: CC1(C2=CC(C(CC3)=NNC3=O)=CC=C2NC1=O)C
Biological Activity: Indolidan (LY195115) is an orally active cardiotonic agent and a selective cyclic nucleotide phosphodiesterase inhibitor. Indolidan has a Ki of 80 nM for sarcoplasmic reticulum phosphodiesterase (SR-PDE). Indolidan exhibits positive inotropic and vasodilator effects. Indolidan can be used in the research of diseases such as congestive heart failure[1][2].
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Indolidan | Indolidan (LY195115) is an orally active cardiotonic agent and a selective cyclic nucleotide phosphodiesterase inhibitor. Indolidan has a Ki of 80 nM for sarcoplasmic reticulum phosphodiesterase (SR-PDE). Indolidan exhibits positive inotropic and vasodilator effects. Indolidan can be used in the research of diseases such as congestive heart failure. | |||||||||||||||||||||
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References
- [1]. Hayes JS, et al. Pharmacology of LY195115, a potent, orally active cardiotonic with a long duration of action. J Cardiovasc Pharmacol. 1987 Apr;9(4):425-34. [Content Brief]
- [2]. Kauffman RF, et al. LY195115: a potent, selective inhibitor of cyclic nucleotide phosphodiesterase located in the sarcoplasmic reticulum. Mol Pharmacol. 1986 Dec;30(6):609-16. [Content Brief]
