Oberadilol (monoethyl maleate)
Oberadilol monoethyl maleate (CID-3047798 monoethyl maleate) is a Phosphodiesterase III inhibitor, non-selective β-adrenergic receptor blocker, vasodilator and positive inotropic agent. Oberadilol monoethyl maleate reduces left ventricular end-diastolic volume. Oberadilol monoethyl maleate is used in research related to chronic congestive heart failure and SARS-CoV-2 infection.
For research use only. We do not sell to patients.
- CAS No.: 114856-47-2
- Formula: C31H38ClN5O7
- Molecular Weight:628.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
PDE Ⅲ |
β adrenergic receptor |
In Vitro
Oberadilol monoethyl maleate is a pyridazinone derivative with vasodilatory, β-adrenergic blocking, and type III phosphodiesterase inhibitory activities[1].
Oberadilol monoethyl maleate reduces left ventricular end-diastolic volume and tends to increase ejection fraction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 114856-47-2
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Molecular Weight 628.12
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Formula C31H38ClN5O7
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SMILES
C(/C=C\C(O)=O)(OCC)=O.CC1C(=NNC(=O)C1)C2=CC=C(NCC(NCC(COC3=C(C#N)C=CC(Cl)=C3)O)(C)C)C=C2
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Synonyms
CID-3047798 (monoethyl maleate); TZC 5665
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Araki S, et al. Cardiac and hemodynamic effects of TZC-5665, a novel pyridazinone derivative, and its metabolite in humans and dogs. General pharmacology. 1997 Apr;28(4):545-53. [Content Brief]
[3]. Srivastava A, et al. Exploring nature's bounty: identification of Withania somnifera as a promising source of therapeutic agents against COVID-19 by virtual screening and in silico evaluation. J Biomol Struct Dyn. 2022 Mar;40(4):1858-1908. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oberadilol (monoethyl maleate) Related Classifications
HY-19088A Related Classifications
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Keywords
- Oberadilol (monoethyl maleate)
- 114856-47-2
- CID-3047798 monoethyl
- TZC 5665
- TZC5665
- TZC 5665
- TZC-5665
- Phosphodiesterase (PDE)
- Adrenergic Receptor
- SARS-CoV
- protease inhibitor
- enzyme inhibitor
- chronic congestive heart failure
- GPCR ligand
- COVID-19
- SARS-CoV main protease
- phosphodiesterase-III
- β-adrenergic receptor
- Lipinski's rule of five
- SARS-CoV-2 main protease
- Inhibitor
- inhibitor
- inhibit