114856-47-2
Chemical Structure
Oberadilol (monoethyl maleate)
Synonym(s): CID-3047798 (monoethyl maleate); TZC 5665
- CAS No.: 114856-47-2
- Formula:C31H38ClN5O7
- Molecular Weight:628.12
IUPAC Name: 4-chloro-2-(2-hydroxy-3-((2-methyl-1-((4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)amino)propan-2-yl)amino)propoxy)benzonitrile (Z)-4-ethoxy-4-oxobut-2-enoate
InChIKey: TZXOVBAUUXGKJG-QGAMPUOQSA-N
SMILES: C(/C=C\C(O)=O)(OCC)=O.CC1C(=NNC(=O)C1)C2=CC=C(NCC(NCC(COC3=C(C#N)C=CC(Cl)=C3)O)(C)C)C=C2
Biological Activity: Oberadilol monoethyl maleate (CID-3047798 monoethyl maleate) is a Phosphodiesterase III inhibitor, non-selective β-adrenergic receptor blocker, vasodilator and positive inotropic agent. Oberadilol monoethyl maleate reduces left ventricular end-diastolic volume. Oberadilol monoethyl maleate is used in research related to chronic congestive heart failure and SARS-CoV-2 infection[1][2][3][4].
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Oberadilol (monoethyl maleate) | Oberadilol monoethyl maleate (CID-3047798 monoethyl maleate) is a Phosphodiesterase III inhibitor, non-selective β-adrenergic receptor blocker, vasodilator and positive inotropic agent. Oberadilol monoethyl maleate reduces left ventricular end-diastolic volume. Oberadilol monoethyl maleate is used in research related to chronic congestive heart failure and SARS-CoV-2 infection. | |||||||||||||||||||||
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- [1]. Araki S, et al. Cardiac and hemodynamic effects of TZC-5665, a novel pyridazinone derivative, and its metabolite in humans and dogs. General pharmacology. 1997 Apr;28(4):545-53. [Content Brief]
- [2]. Asif M. The biological potentials of substituted 1, 2-diazines: A review on versatile pyridazine derivatives[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(10): 707.
- [3]. Srivastava A, et al. Exploring nature's bounty: identification of Withania somnifera as a promising source of therapeutic agents against COVID-19 by virtual screening and in silico evaluation. J Biomol Struct Dyn. 2022 Mar;40(4):1858-1908. [Content Brief]
- [4]. Imran M, et al. Study of various pyridazine and phthalazine drugs with diverse therapeutical and agrochemical activities[J]. Russian Journal of Bioorganic Chemistry, 2020, 46(5): 745-767.
Keywords
