123297-52-9
Chemical Structure
ICI-170777
- CAS No.: 123297-52-9
- Formula:C9H9N3OS
- Molecular Weight:207.25
IUPAC Name: 6-methyl-5-(pyridin-4-yl)-3,6-dihydro-2H-1,3,4-thiadiazin-2-one
InChIKey: PXZLHVGFLSUUIW-UHFFFAOYSA-N
SMILES: O=C1SC(C)C(C2=CC=NC=C2)=NN1
Biological Activity: ICI-170777 is an orally active cardiotonic agent and type III Phosphodiesterase inhibitor, with an IC50 of 2.5 μM against cyclic AMP phosphodiesterase type III from canine cardiac fractions. ICI-170777 inhibits Aldrin epoxidase and pentobarbital metabolism. It enhances β-adrenergic receptor-mediated positive inotropic effects without causing chronotropic effects, while also exerting balanced arteriolar/venular vasodilator, platelet aggregation inhibitor and smooth muscle relaxant activities. ICI-170777 restores cardiac function in an acute canine heart failure model, exhibits additive effects when combined with Ouabain (HY-B1457), and shows no significant activity against multiple receptor classes or non-cardiac systems. ICI-170777 can be used in research related to congestive heart failure[1][2][3].
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ICI-170777 | ICI-170777 is an orally active cardiotonic agent and type III Phosphodiesterase inhibitor, with an IC50 of 2.5 μM against cyclic AMP phosphodiesterase type III from canine cardiac fractions. ICI-170777 inhibits Aldrin epoxidase and pentobarbital metabolism. It enhances β-adrenergic receptor-mediated positive inotropic effects without causing chronotropic effects, while also exerting balanced arteriolar/venular vasodilator, platelet aggregation inhibitor and smooth muscle relaxant activities. ICI-170777 restores cardiac function in an acute canine heart failure model, exhibits additive effects when combined with Ouabain (HY-B1457), and shows no significant activity against multiple receptor classes or non-cardiac systems. ICI-170777 can be used in research related to congestive heart failure. | |||||||||||||||||||||
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- [1]. McKillop D, et al. Different inhibition and induction profiles of hepatic drug metabolism in rats and dogs by two structurally related pyridyl diazinone cardiotonic agents. Biochem Pharmacol. 1991 Feb 1;41(3):411-7. [Content Brief]
- [2]. Collis MG, et al. The cardiovascular pharmacology of ICI 170777 ((6RS)-6-methyl-5-(pyrid-4-yl)-3H,6H-1,3,4- thiadiazin-2-one) a novel compound with positive inotropic and vasodilator effects. Br J Pharmacol. 1989 Jun;97(2):409-18. [Content Brief]
- [3]. Collis M G. ICI 170777: a new compound with positive inotropic and vasodilator actions[J]. Cardiovascular Drug Reviews, 1991, 9(1): 18-29.
Keywords
