75898-90-7
75898-90-7
Chemical Structure
Amrinone lactate
- CAS. Nr.: 75898-90-7
- Formula:C13H15N3O4
- Molecular Weight:277.28
IUPAC Name: 5-amino-[3,4'-bipyridin]-6(1H)-one 3-hydroxypropanoate
InChIKey: NSLALHQEHXBOHP-UHFFFAOYSA-N
SMILES: O=C(O)CCO.O=C1C(N)=CC(C2=CC=NC=C2)=CN1
Biological Activity: Amrinone lactate is a positive inotropic-vasodilator agent. Amrinone lactate is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone lactate is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent[1][2][3].
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Amrinone lactate | Amrinone lactate is a positive inotropic-vasodilator agent. Amrinone lactate is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone lactate is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent. | |||||||||||||||||||||
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References
- [1]. A A Alousi, et al. The Beneficial Effect of Amrinone on Acute Drug-Induced Heart Failure in the Anaesthetised Dog. Cardiovasc Res. 1985 Aug;19(8):483-94. [Content Brief]
- [2]. S Ichioka, et al. Clinical Use of Amrinone (A Selective Phosphodiesterase III Inhibitor) in Reconstructive Surgery. Plast Reconstr Surg. 2001 Dec;108(7):1931-7. [Content Brief]
- [3]. T H LeJemtel, et al. Amrinone: A New Non-Glycosidic, Non-Adrenergic Cardiotonic Agent Effective in the Treatment of Intractable Myocardial Failure in Man. Circulation. 1979 Jun;59(6):1098-104. [Content Brief]
Keywords
