97730-95-5
97730-95-5
Chemical Structure
DPI 201-106
Synonym(s): SDZ 201106
- CAS No.: 97730-95-5
- Formula:C29H30N4O2
- Molecular Weight:466.57
IUPAC Name: 4-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy)-1H-indole-2-carbonitrile
InChIKey: BYBYHCOEAFHGJL-UHFFFAOYSA-N
SMILES: N#CC(N1)=CC2=C1C=CC=C2OCC(O)CN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3
Biological Activity: DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect[1][2][3].
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DPI 201-106 | 99.49% | DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect. | ||||||||||||||||||||
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DPI 201-106 (Standard) | ≥98% | DPI 201-106 (Standard) is the analytical standard of DPI 201-106. This product is intended for research and analytical applications. DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect. | ||||||||||||||||||||
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References
- [1]. G Scholtysik, et al. DPI 201-106, a novel cardioactive agent. Combination of cAMP-independent positive inotropic, negative chronotropic, action potential prolonging and coronary dilatory properties. Naunyn Schmiedebergs Arch Pharmacol.1985 May;329(3):316- [Content Brief]
- [2]. G Scholtysik, et al. Interaction of DPI 201-106 with cardiac glycosides. J Cardiovasc Pharmacol. 1989 Feb;13(2):342-7. [Content Brief]
- [3]. M Mevissen, et al. Identification of a cardiac sodium channel insensitive to synthetic modulators. J Cardiovasc Pharmacol Ther. 2001 Apr;6(2):201-12. [Content Brief]
Keywords
