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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
pro-apoptotic BH3 domain
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "pro-apoptotic BH3 domain" in MCE Product Catalog:
Cat. No.: HY-P1889
CAS No.: 721885-31-0
Target:
Research Areas:
Bim BH3, Peptide IV is an Aβ42-binding peptide and the pro-apoptotic BH3 domain of the BIM protein. Bim BH3, Peptide IV binds Aβ42 with a Kd of 7.1 μM. Bim BH3, Peptide IV modulates Aβ42 structure, fibrillization pathways, aggregate morphology, and membrane interactions, inhibiting fibril formation while enhancing protofibril assembly. Bim BH3, Peptide IV promotes Aβ42 β-sheet formation and accelerates aggregation. Bim BH3, Peptide IV enhances Aβ42 membrane internalization and bilayer stiffening. Bim BH3, Peptide IV induces neuronal cell death by enhancing BH3-induced membrane interactions of Aβ42 prefibrillar species. Bim BH3, Peptide IV can be used for research on Alzheimer's disease .
Cat. No.: HY-P1889A
Target:
Research Areas:
Bim BH3, Peptide IV TFA is an Aβ42-binding peptide and the pro-apoptotic BH3 domain of the BIM protein. Bim BH3, Peptide IV TFA binds Aβ42 with a Kd of 7.1 μM. Bim BH3, Peptide IV TFA modulates Aβ42 structure, fibrillization pathways, aggregate morphology, and membrane interactions, inhibiting fibril formation while enhancing protofibril assembly. Bim BH3, Peptide IV TFA promotes Aβ42 β-sheet formation and accelerates aggregation. Bim BH3, Peptide IV TFA enhances Aβ42 membrane internalization and bilayer stiffening. Bim BH3, Peptide IV TFA induces neuronal cell death by enhancing BH3-induced membrane interactions of Aβ42 prefibrillar species. Bim BH3, Peptide IV TFA can be used for research on Alzheimer's disease .
Cat. No.: HY-P1733
Synonyms: BMF-Y
Target:
Research Areas:
BMf-BH3 (BMF-Y) is a pro-apoptotic (apoptosis) protein containing only the BH3 domain, and also serves as a cellular stress sentinel for actin cytoskeleton signaling. BMf-BH3 binds to pro-survival Bcl-2 family members via its BH3 domain to block their anti-apoptotic functions. BMf-BH3 can be used in cancer-related research .
Cat. No.: HY-161577
CAS No.: 701231-39-2
Target:
Research Areas:
BFC1103 is a small-molecule compound whose primary mechanism of action involves interaction with a specific domain of Bcl-2, particularly its loop domain. This interaction induces a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homology 3) domain, thereby switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of Bax or Bak, both of which are key proteins involved in the intrinsic apoptotic pathway mediated by mitochondria. BFC1103 has successfully inhibited lung metastasis of triple-negative breast cancer in mouse models. It can be utilized in studying the roles of Bcl-2 family proteins in cancer development and how they impact the survival and proliferation of cancer cells .
Cat. No.: HY-P1733A
Synonyms: BMF-Y TFA
Target:
Research Areas:
BMf-BH3 TFA (BMF-Y TFA) is a pro-apoptotic (apoptosis) protein containing only the BH3 domain, and also serves as a cellular stress sentinel for actin cytoskeleton signaling. BMf-BH3 TFA binds to pro-survival Bcl-2 family members via its BH3 domain to block their anti-apoptotic functions. BMf-BH3 TFA can be used in cancer-related research .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
