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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
restriction of intramolecular motion
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "restriction of intramolecular motion" in MCE Product Catalog:
Cat. No.: HY-P12218
CAS No.: 2559743-70-1
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CVNTANST is a fluorescent peptide that targets vimentin. CVNTANST binds to vimentin and restricts the ethylene bond rotation of tetraphenylethylene, triggering fluorescence turn-on via the restriction of intramolecular motion mechanism. CVNTANST enables wash-free fluorescence detection and imaging of vimentin-positive epithelial-mesenchymal transition (EMT)-type cancer cells and tumor tissues. CVNTANST can be used for research on EMT-type cancers .
Cat. No.: HY-D3075
CAS No.: 2490504-23-7
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TPE-2E N-oxide is a fluorescent probe used for hypoxia detection and tumor hypoxia imaging. Due to its active intramolecular motion, TPE-2E N-oxide shows no fluorescence in aqueous solution. In hypoxic environments, its N-oxide group undergoes two-electron reduction by CYP450 reductase and other heme protein reductases expressed under hypoxia, forming hydrophobic aggregates that trigger aggregation-induced emission through the restriction of intramolecular motion. TPE-2E N-oxide exhibits selective lipid droplet localization in cells. The absorption wavelength of TPE-2E N-oxide in dichloromethane is 313 nm; in a 99% hexane/dichloromethane mixed system, its excitation wavelength is 330 nm and emission wavelength is 460 nm. For in vitro cell imaging, excitation is performed at 405 nm, with an emission wavelength range of 430-560 nm .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
