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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
ribonucleotide reductase M2
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "ribonucleotide reductase M2" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: 3-AP; PAN-811; OCX191
Target:
Research Areas:
Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.
3
3 Cited Publications
Synonyms: Oxaphenamide; 4'-Hydroxysalicylanilide
Target:
Osalmid is a ribonucleotide reductase small subunit M2 (RRM2) targeting compound; suppresses ribonucleotide reductase activity with an IC50 of 8.23 μM.
2
Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and exhibits good potential for vitiligo research. Monobenzone is a potent inhibitor of RNR (Ribonucleotide reductase) enzyme activity by targeting RRM2 (a regulatory small subunit M2 of RNR) protein, and thus has significant anti-leukemia efficacy in vitro and in vivo. Monobenzone inhibits acute myeloid leukemia (AML) cells proliferation and DNA synthesis, induces cell cycle arrest, and Apoptosis .
Target:
Research Areas:
GW8510 is a potent cyclin-dependent kinase-2 (CDK2) inhibitor. GW8510 is also a ribonucleotide reductase M2 (RRM2) inhibitor. GW8510 exhibits neuroprotective and anticancer activities .
Cat. No.: HY-W015940
CAS No.: 1455-77-2
Target:
Guanazole is a ribonucleotide reductase (RNR) inhibitor that blocks replicative DNA synthesis by inhibiting deoxyribonucleotide biosynthesis. Guanazole selectively inhibits DNA synthesis in rapidly proliferating tissues, induces replication stress and G2/M phase arrest in Schizosaccharomyces pombe, and exhibits myelosuppressive, immunosuppressive, and anti-L1210 leukemia activities. Guanazole does not induce DNA repair and only shows slight mutagenicity towards Salmonella typhimurium TA102. Guanazole serves as an alternative tool to Hydroxyurea (HY-B0313) for replication checkpoint studies in Schizosaccharomyces pombe. Guanazole can be applied in research related to leukemia and solid tumors .
Cat. No.: HY-10082B
CAS No.: 216240-62-9
Synonyms: 3-AP hydrochloride; PAN-811 hydrochloride; OCX191 hydrochloride
Target:
Research Areas:
Triapine (hydrochloride) is the hydrochloride form of Triapine (HY-10082). Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer .
Cat. No.: HY-10082S1
Synonyms: 3-AP-d3; PAN-811-d3; OCX191-d3
Cat. No.: HY-10082R
CAS No.: 143621-35-6
Synonyms: 3-AP (Standard); PAN-811 (Standard); OCX191 (Standard)
Target:
Research Areas:
Triapine (Standard) is the analytical standard of Triapine (HY-10082). This product is intended for research and analytical applications. Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.
Cat. No.: HY-P71267
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: RRM2; FLJ25102; Prev. C2orf48; Chromosome 2 Open Reading Frame 48; Ribonucleoside-Diphosphate reductase Subunit M2; Uncharacterized Protein C2orf48; ribonucleotide reductase Small Subunit; RR2M; ribonucleotide reductase Small Chain; R2; ribonucleotide Red
Species:
Human
Source:
HEK293
Cat. No.: HY-P76534
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: RRM2B; P53-Inducible ribonucleotide reductase Small Subunit 2 Short Form Beta; ribonucleotide reductase Regulatory TP53 Inducible Subunit M2B; P53-Inducible ribonucleotide reductase Small Subunit 2 Homolog; P53R2; Ribonucleoside-Diphosphate reductase; P53
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
