103-16-2
Chemical Structure
Monobenzone
- No. CAS: 103-16-2
- Formula:C13H12O2
- Molecular Weight:200.24
IUPAC Name: 4-(benzyloxy)phenol
InChIKey: VYQNWZOUAUKGHI-UHFFFAOYSA-N
SMILES: OC1=CC=C(C=C1)OCC2=CC=CC=C2
Biological Activity: Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and exhibits good potential for vitiligo research. Monobenzone is a potent inhibitor of RNR (Ribonucleotide reductase) enzyme activity by targeting RRM2 (a regulatory small subunit M2 of RNR) protein, and thus has significant anti-leukemia efficacy in vitro and in vivo. Monobenzone inhibits acute myeloid leukemia (AML) cells proliferation and DNA synthesis, induces cell cycle arrest, and Apoptosis [1][2].
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Monobenzone | 99.98% | Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and exhibits good potential for vitiligo research. Monobenzone is a potent inhibitor of RNR (Ribonucleotide reductase) enzyme activity by targeting RRM2 (a regulatory small subunit M2 of RNR) protein, and thus has significant anti-leukemia efficacy in vitro and in vivo. Monobenzone inhibits acute myeloid leukemia (AML) cells proliferation and DNA synthesis, induces cell cycle arrest, and Apoptosis . | ||||||||||||||||||||
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Monobenzone (Standard) | 99.85% | Monobenzone (Standard) is the analytical standard of Monobenzone. This product is intended for research and analytical applications. Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research. | ||||||||||||||||||||
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References
- [1]. Zhu Y, et al. A mouse model of vitiligo induced by monobenzone. Exp Dermatol. 2013 Jul;22(7):499-501. doi: 10.1111/exd.12184. [Content Brief]
- [2]. Dong J, et al. Identification of Monobenzone as a Novel Potential Anti-Acute Myeloid Leukemia Agent That Inhibits RNR and Suppresses Tumour Growth in Mouse Xenograft Model. Cancers (Basel). 2022 Sep 27;14(19):4710. [Content Brief]
