103-16-2
103-16-2
Chemical Structure
Monobenzone
- CAS No.: 103-16-2
- Formula:C13H12O2
- Molecular Weight:200.24
IUPAC Name: 4-(benzyloxy)phenol
InChIKey: VYQNWZOUAUKGHI-UHFFFAOYSA-N
SMILES: OC1=CC=C(C=C1)OCC2=CC=CC=C2
Biological Activity: Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and exhibits good potential for vitiligo research. Monobenzone is a potent inhibitor of RNR (Ribonucleotide reductase) enzyme activity by targeting RRM2 (a regulatory small subunit M2 of RNR) protein, and thus has significant anti-leukemia efficacy in vitro and in vivo. Monobenzone inhibits acute myeloid leukemia (AML) cells proliferation and DNA synthesis, induces cell cycle arrest, and Apoptosis [1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Monobenzone | 99.98% | Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and exhibits good potential for vitiligo research. Monobenzone is a potent inhibitor of RNR (Ribonucleotide reductase) enzyme activity by targeting RRM2 (a regulatory small subunit M2 of RNR) protein, and thus has significant anti-leukemia efficacy in vitro and in vivo. Monobenzone inhibits acute myeloid leukemia (AML) cells proliferation and DNA synthesis, induces cell cycle arrest, and Apoptosis . | ||||||||||||||||||||
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Monobenzone (Standard) | 99.85% | Monobenzone (Standard) is the analytical standard of Monobenzone. This product is intended for research and analytical applications. Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research. | ||||||||||||||||||||
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4-Methoxybiphenyl | 99.84% | 4-Methoxybiphenyl is a cytochrome P450-dependent microsomal monooxygenase system substrate and metabolite precursor. 4-Methoxybiphenyl undergoes O-demethylation to generate 4-hydroxybiphenyl. 4-Methoxybiphenyl undergoes sulphation and glucuronidation conjugation; inhibition of sulphation shifts metabolism toward increased glucuronidation and unconjugated 4-hydroxybiphenyl accumulation. 4-Methoxybiphenyl serves as a model substrate for studying phase II metabolic conjugation pathway balance in rat isolated hepatocytes. | ||||||||||||||||||||
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(E)-4-Stilbenol | (E)-4-Stilbenol is a hydroxylated stilbene compound and also a fungicide. (E)-4-Stilbenol inhibits the growth of Gloeophyllum trabeum and Poria placenta. (E)-4-Stilbenol is applicable to research related to fungal infections. | |||||||||||||||||||||
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4-Phenoxybenzylamine | 98.45% | 4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against FL NS3/4a. | ||||||||||||||||||||
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1-(Benzyloxy)-2-iodobenzene | 99.23% | 1-(Benzyloxy)-2-iodobenzene is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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Bisphenol F | 99.93% | Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260). | ||||||||||||||||||||
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Bisphenol F-13C6 | Bisphenol F-13C6 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260). | |||||||||||||||||||||
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Bisphenol F-13C12 | Bisphenol F-13C12 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260). | |||||||||||||||||||||
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4-Benzylphenol | 4-Benzylphenol (4HDPM), a structural analog of Bisphenol F (HY-W014901), has estrogenic activity in vitro and in vivo. 4-Benzylphenol can be used in plastics as a germicide, antiseptic, preservative, and antioxidant, and can be used in during organic synthesis. | |||||||||||||||||||||
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4-MDM | 99.64% | 4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A4 Hydrolase (LTA4H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by LTA4H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA4H. 4-MDM can be used for research on lung diseases. | ||||||||||||||||||||
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4-Biphenylmethanol (Standard) | ≥98% | [1,1'-Biphenyl]-4-ylmethanol (Standard) is the analytical standard of [1,1'-Biphenyl]-4-ylmethanol. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Zhu Y, et al. A mouse model of vitiligo induced by monobenzone. Exp Dermatol. 2013 Jul;22(7):499-501. doi: 10.1111/exd.12184. [Content Brief]
- [2]. Dong J, et al. Identification of Monobenzone as a Novel Potential Anti-Acute Myeloid Leukemia Agent That Inhibits RNR and Suppresses Tumour Growth in Mouse Xenograft Model. Cancers (Basel). 2022 Sep 27;14(19):4710. [Content Brief]
