1455-77-2
Chemical Structure
Guanazole
- CAS No.: 1455-77-2
- Formula:C2H5N5
- Molecular Weight:99.09
IUPAC Name: 4H-1,2,4-triazole-3,5-diamine
InChIKey: PKWIYNIDEDLDCJ-UHFFFAOYSA-N
SMILES: NC1=NN=C(N)N1
Biological Activity: Guanazole is a ribonucleotide reductase (RNR) inhibitor that blocks replicative DNA synthesis by inhibiting deoxyribonucleotide biosynthesis. Guanazole selectively inhibits DNA synthesis in rapidly proliferating tissues, induces replication stress and G2/M phase arrest in Schizosaccharomyces pombe, and exhibits myelosuppressive, immunosuppressive, and anti-L1210 leukemia activities. Guanazole does not induce DNA repair and only shows slight mutagenicity towards Salmonella typhimurium TA102. Guanazole serves as an alternative tool to Hydroxyurea (HY-B0313) for replication checkpoint studies in Schizosaccharomyces pombe. Guanazole can be applied in research related to leukemia and solid tumors[1][2][3][4][5].
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Guanazole | Guanazole is a ribonucleotide reductase (RNR) inhibitor that blocks replicative DNA synthesis by inhibiting deoxyribonucleotide biosynthesis. Guanazole selectively inhibits DNA synthesis in rapidly proliferating tissues, induces replication stress and G2/M phase arrest in Schizosaccharomyces pombe, and exhibits myelosuppressive, immunosuppressive, and anti-L1210 leukemia activities. Guanazole does not induce DNA repair and only shows slight mutagenicity towards Salmonella typhimurium TA102. Guanazole serves as an alternative tool to Hydroxyurea (HY-B0313) for replication checkpoint studies in Schizosaccharomyces pombe. Guanazole can be applied in research related to leukemia and solid tumors. | |||||||||||||||||||||
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References
- [1]. Suter W, et al. DNA repair induced by various mutagens in rat hepatocyte primary cultures measured in the presence of hydroxyurea, guanazole or aphidicolin. Mutation research. 1990 Aug;231(2):251-64.
- [2]. Paul MA, et al. A simple method for long-term drug infusion in mice: evaluation of guanazole as a model (38488). Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1975 Jan;148(1):118-22.
- [3]. Alyahya MY, et al. Replication stress induced by the ribonucleotide reductase inhibitor guanazole, triapine and gemcitabine in fission yeast. FEMS yeast research. 2022 Mar 24;22(1):foac014.
- [4]. Durjava MK, et al. Experimental assessment of the environmental fate and effects of triazoles and benzotriazole. Alternatives to laboratory animals : ATLA. 2013 Mar;41(1):65-75.
- [5]. HY-W015940-3.pdf
