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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
sclerostin
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "sclerostin" in MCE Product Catalog:
1
Target:
Research Areas:
Cat. No.: HY-P99186
CAS No.: 1132758-87-2
Target:
Research Areas:
Cat. No.: HY-170788
CAS No.: 3074559-75-1
Target:
Research Areas:
PDE7A-IN-1 is an orally active and selective PDE7A inhibitor with an IC50 of 0.0037 μM against PDE7A. PDE7A-IN-1 shows excellent isozyme selectivity over PDE7B. PDE7A-IN-1 elevates intracellular cAMP levels, suppresses ECR5 enhancer activity and reduces sclerostin expression. PDE7A-IN-1 significantly increases bone mineral density in rats. PDE7A-IN-1 can be used for the study of osteoporosis .
Cat. No.: HY-P99398
CAS No.: 1847394-95-9
Synonyms: BPS 804
Target:
Research Areas:
BMD4503-2 is a quinoxaline derivative with inhibitory activity against LRP5/6-sclerostin interactions. BMD4503-2 restores the activity of the Wnt/β-catenin signaling pathway by competitively binding to the LRP5/6-sclerostin complex. BMD4503-2 can be used in the study of Wnt signaling pathways in bone development, maintenance and osteoporosis .
Cat. No.: HY-163513
CAS No.: 2515609-54-6
Target:
Research Areas:
AACA is an inhibitor for sclerostin, that binds sclerostin on loop3 region with Kd of 15.4 nM. AACA exhibits anti-osteoporosis activity through Wnt signaling pathway .
Cat. No.: HY-P991617
CAS No.: 1798349-30-0
Cat. No.: HY-P992113
CAS No.: 3061142-96-6
Synonyms: AGA2118
Research Areas:
Evabosmig (AGA2118) is a humanized bispecific monoclonal antibody targeting sclerostin (SOST/sclerostin) and DKK1. SOST and DKK1 are two key secreted negative regulators of the intramedullary Wnt/β-catenin pathway. Evabosmig possesses activities to induce bone formation, inhibit bone resorption and increase bone mineral density. Evabosmig is applicable for research related to osteoporosis .
Cat. No.: HY-P700829
Purity: ≥ 95%, as determined by reducing Bis-Tris PAGE.
Synonyms: SOST; Sclerosteosis; sclerostin; SOST1; DAND6; CDD; VBCH
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-185590
CAS No.: 3084453-02-8
Research Areas:
tri-GalNAc-phosphoric acid is a specific ligand of ASGPR with cell-specific internalization capability. tri-GalNAc-phosphoric acid can mediate the delivery of conjugated sclerostin aptamers to lysosomes of cells expressing ASGPR. tri-GalNAc-phosphoric acid is applicable to anticancer research .
Cat. No.: HY-P78765
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SOSTDC1; Ectodermal BMP Inhibitor; sclerostin Domain Containing 1; DKFZp564D206; USAG1; Wise; sclerostin Domain-Containing Protein 1; Uterine Sensitization-Associated Protein-1; Ectodin; Cystine-Knot Containing Secreted Protein; DAND7; CDA019; Uterine Sen
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
