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Isoforms Recommended:	SOST

Results for "

sclerostin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphodiesterase (PDE) (1) Wnt (4)
By Research Areas:	Cancer (3) Endocrinology (2) Inflammation/Immunology (1) Metabolic Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-170788

PDE7A-IN-1	Phosphodiesterase (PDE)	Metabolic Disease
PDE7A-IN-1 is an orally active and selective PDE7A inhibitor with an IC₅₀ of 0.0037 μM against PDE7A. PDE7A-IN-1 shows excellent isozyme selectivity over PDE7B. PDE7A-IN-1 elevates intracellular cAMP levels, suppresses ECR5 enhancer activity and reduces sclerostin expression. PDE7A-IN-1 significantly increases bone mineral density in rats. PDE7A-IN-1 can be used for the study of osteoporosis .

HY-125146

BMD4503-2	Wnt	Others
BMD4503-2 is a quinoxaline derivative with inhibitory activity against *LRP5/6-sclerostin* interactions. BMD4503-2 restores the activity of the Wnt/β-catenin signaling pathway by competitively binding to the *LRP5/6-sclerostin* complex. BMD4503-2 can be used in the study of Wnt signaling pathways in bone development, maintenance and osteoporosis .

HY-163513

AACA	Wnt	Endocrinology
AACA is an inhibitor for *sclerostin, that binds sclerostin* on loop3 region with K_d of 15.4 nM. AACA exhibits anti-osteoporosis activity through Wnt signaling pathway .

HY-169508

BMD4503-1	Wnt	Others
BMD4503-1 is a quinoxaline derivative. BMD4503-1 can inhibit the *LRP5/6-Sclerostin* interaction and regulate the Wnt signaling pathway .

HY-P991617

AMG-167	Wnt	Cancer
AMG-167 is an anti-cancer monoclonal antibody targeting *sclerostin*. AMG-167 can be studied in research for osteoporosis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9982

Romosozumab 1 Publications Verification AMG-785; CDP-7851	Inhibitory Antibodies	Endocrinology Cancer
Romosozumab is a humanized monoclonal *anti-sclerostin* antibody*, it promotes bone formation and inhibits bone resorption by inhibiting sclerostin*. Romosozumab can be used for the research of osteoporosis .

HY-P99186

Blosozumab	Inhibitory Antibodies	Others
Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis .

HY-P99398

Setrusumab BPS 804	Inhibitory Antibodies	Inflammation/Immunology Cancer
Setrusumab (BPS 804) is a fully human monoclonal antibody targets *sclerostin*. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer .

HY-P991617

AMG-167	Wnt	Cancer
AMG-167 is an anti-cancer monoclonal antibody targeting *sclerostin*. AMG-167 can be studied in research for osteoporosis .

Species:	Human (2) Mouse (2) Rat (1) Cynomolgus (1)
Tag:	His (6) Avi (1) Myc (1)
Source:	HEK293 (5) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71623

	SOST Protein, Rat (Myc, His) Sost; sclerostin	Rat	E. coli
	SOST protein inhibits bone growth by suppressing Wnt signaling and interacting with LRP4 and LRP5. Its interactions with LRP4 and LRP5 play crucial roles in suppressing Wnt signaling. The involvement of SOST in interactions with LRP6 highlights its regulatory role in bone growth. SOST Protein, Rat (Myc, His) is the recombinant rat-derived SOST protein, expressed by E. coli , with N-His, C-Myc labeled tag.

HY-P70717

	SOST Protein, Mouse (HEK293, His) sclerostin; Sost	Mouse	HEK293
	SOST proteins act as potent inhibitors of bone growth by effectively inhibiting Wnt signaling and subsequent bone formation. SOST exerts its inhibitory effect by interacting with key Wnt pathway components, including LRP4, LRP5, and LRP6. SOST Protein, Mouse (HEK293, His) is the recombinant mouse-derived SOST protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70756

	SOST Protein, Human (HEK293, His) sclerostin; SOST; UNQ2976; PRO7455; PRO7476	Human	HEK293
	SOST proteins act as potent inhibitors of bone growth by effectively inhibiting Wnt signaling and subsequent bone formation. SOST exerts its inhibitory effect by interacting with key Wnt pathway components, including LRP4, LRP5, and LRP6. SOST Protein, Human (HEK293, His) is the recombinant human-derived SOST protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700829

	SOST Protein, Cynomolgus (HEK293, His) sclerostin; SOST; VBCHsclerosteosis; CDD; DAND6; SOST1; VBCH	Cynomolgus	HEK293
	SOST proteins act as potent inhibitors of bone growth by effectively inhibiting Wnt signaling and subsequent bone formation. SOST exerts its inhibitory effect by interacting with key Wnt pathway components, including LRP4, LRP5, and LRP6. SOST Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived SOST protein, expressed by HEK293 , with C-His labeled tag.

HY-P78209

	SOST Protein, Human (Biotinylated, HEK293, His-Avi) sclerostin; SOST; VBCHsclerosteosis; CDD; DAND6; SOST1; VBCH	Human	HEK293
	SOST proteins act as potent inhibitors of bone growth by effectively inhibiting Wnt signaling and subsequent bone formation. SOST exerts its inhibitory effect by interacting with key Wnt pathway components, including LRP4, LRP5, and LRP6. SOST Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived SOST protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P79350

	USAG-1 Protein, Mouse (HEK293, His) sclerostin domain-containing protein 1; SOSTDC1; Ectodermal BMP inhibitor; sclerostin-like protein; Uterine sensitization-associated gene 1 protein; USAG-1; Sostl; Usag1; sclerostin Domain Containing Protein 1/Uterine Sensitization-associated Gene 1 Prote	Mouse	HEK293
	The USAG1 protein emerges as a potential modulator in the complex process of endometrial receptivity and sensitization of implanted decidual cells. By enhancing Wnt signaling and inhibiting TGF-β signaling, USAG1 plays a regulatory role in key molecular pathways during these reproductive events. USAG-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived USAG1 protein, expressed by HEK293 , with C-10*His tag.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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