2. Inhibitory Antibodies
  3. Blosozumab

Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis.

For research use only. We do not sell to patients.

Blosozumab Chemical Structure

Blosozumab Chemical Structure

CAS No. : 1132758-87-2

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Blosozumab Related Antibodies

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Description

Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis[1][2].

IC50 & Target

sclerostin (SOST)[1]
In Vivo

Blosozumab (1-100 mg/kg, i.v.) shows effects of hyperostosis in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats [2]
Dosage: 1, 10, and 100 mg/kg
Administration: Intravenous injection (i.v.), once every 3 days (5-week study) or once weekly (6-month study)
Result: Observed the bone anabolic effects.
Showed significant bleeding and morbidity at 100 mg/kg.
Decreases in the numbers of platelets.
Increased number of bone marrow megakaryocytes at 100 mg/kg.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Blosozumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.20%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Blosozumab1132758-87-2OthersOsteoporosissclerostinplateletsbone formationbone resorptionInhibitorinhibitorinhibit

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