3074559-75-1
Chemical Structure
PDE7A-IN-1
- CAS 番号: 3074559-75-1
- Formula:C25H26ClN5O2
- Molecular Weight:463.96
InChIKey: HHARCTVDZIAPSF-LJQANCHMSA-N
SMILES: O=C1N(CC)C(N[C@H]2CN(C(C3=NC=C(C4=CC=CC=C4)C=C3)=O)CC2)=NC(C5CC5)=C1Cl
Biological Activity: PDE7A-IN-1 is an orally active and selective PDE7A inhibitor with an IC50 of 0.0037 μM against PDE7A. PDE7A-IN-1 shows excellent isozyme selectivity over PDE7B. PDE7A-IN-1 elevates intracellular cAMP levels, suppresses ECR5 enhancer activity and reduces sclerostin expression. PDE7A-IN-1 significantly increases bone mineral density in rats. PDE7A-IN-1 can be used for the study of osteoporosis[1].
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PDE7A-IN-1 | 99.83% | PDE7A-IN-1 is an orally active and selective PDE7A inhibitor with an IC50 of 0.0037 μM against PDE7A. PDE7A-IN-1 shows excellent isozyme selectivity over PDE7B. PDE7A-IN-1 elevates intracellular cAMP levels, suppresses ECR5 enhancer activity and reduces sclerostin expression. PDE7A-IN-1 significantly increases bone mineral density in rats. PDE7A-IN-1 can be used for the study of osteoporosis. | ||||||||||||||||||||
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Keywords
