2. Inhibitory Antibodies
  3. Setrusumab

Setrusumab  (Synonyms: BPS 804)

Cat. No.: HY-P99398

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Setrusumab (BPS 804) is a fully human monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer.

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Setrusumab Chemical Structure

Setrusumab Chemical Structure

CAS No. : 1847394-95-9

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Setrusumab Related Antibodies

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Description

Setrusumab (BPS 804) is a fully human monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer[1].

In Vivo

Setrusumab (100 mg/kg; i.v. once a week for 4 weeks) inhibits breast cancer-induced bone metastases and muscle weakness in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old female immune-compromised CB-17/lcr-Prkdcscid/Rj mice with MDA-MB-231 breast cancer cells injection[1]
Dosage: 100 mg/kg
Administration: Intravenous injection; 100 mg/kg once a week for 4 weeks
Result: Significantly inhibited tumor growth in bones and breast cancer cell dissemination into other organs. Inhibited breast cancer-induced osteolytic lesions and subsequent loss of bone mass of the distal femur and of the proximal tibia. Redued phosphorylation of IKKα, IKKβ, and p65.
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[Setrusumab]
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Setrusumab1847394-95-9BPS 804BPS804BPS-804Othersmonoclonal antibodyOIcancerbone metastasemuscle weaknessInhibitorinhibitorinhibit

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