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Cat. No.: HY-P99398

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Biologically Validated

Setrusumab

(Synonyms: BPS 804)

Customer Review

Based on 1 Customer Validation

Setrusumab (BPS 804) is a fully human monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer.

For research use only. We do not sell to patients.

Purity: 99.9%
CAS No.: 1847394-95-9
Molecular Weight:143.44 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Setrusumab Chemical Structure

CAS No.: 1847394-95-9

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Isotype

Human IgG2 lambda

Recommend Isotype Controls

Human IgG2 lambda, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

SOST/Sclerostin

In Vivo

Setrusumab (100 mg/kg; i.v. once a week for 4 weeks) inhibits breast cancer-induced bone metastases and muscle weakness in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8-week-old female immune-compromised CB-17/lcr-Prkdc^scid/Rj mice with MDA-MB-231 breast cancer cells injection^[1]
Dosage:

100 mg/kg
Administration:

Intravenous injection; 100 mg/kg once a week for 4 weeks
Result:

Significantly inhibited tumor growth in bones and breast cancer cell dissemination into other organs. Inhibited breast cancer-induced osteolytic lesions and subsequent loss of bone mass of the distal femur and of the proximal tibia. Redued phosphorylation of IKKα, IKKβ, and p65.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

50964 [NCBI]

Accession

Q9BQB4

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG2 lambda

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Loaded Setrusumab on AHC2 biosensor, can bind SOST Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78209) with an affinity constant of 8.123E-11 M as determined in BLI assay.
Immobilized SOST Protein, Human (HEK293, His, HY-P70756) can bind Setrusumab. The EC₅₀ for this effect is 12.07 ng/mL.

Chemical Information

CAS No. 1847394-95-9
Appearance Liquid
Molecular Weight 143.44 kDa
Color Colorless to light yellow
SMILES

[Setrusumab]
Synonyms

BPS 804
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (256 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Hesse E, et al. Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness. JCI Insight. 2019 Apr 9;5(9):e125543.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Purity & Documentation
References

1/16

Human IgG2 lambda
1/16

Loaded Setrusumab on AHC2 biosensor, can bind SOST Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78209) with an affinity constant of 8.123E-11 M as determined in BLI assay.
1/16

Immobilized SOST Protein, Human (HEK293, His, HY-P70756) can bind Setrusumab. The EC₅₀ for this effect is 12.07 ng/mL.
1/16

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Setrusumab

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Antibody Inhibitor Library