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Cat. No.: HY-P9982

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Biologically Validated

Romosozumab

(Synonyms: AMG-785; CDP-7851)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Romosozumab is a humanized monoclonal anti-sclerostin antibody, it promotes bone formation and inhibits bone resorption by inhibiting sclerostin. Romosozumab can be used for the research of osteoporosis.

For research use only. We do not sell to patients.

Purity: 99.11%
CAS No.: 909395-70-6
Molecular Weight:146.32 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Romosozumab Chemical Structure

CAS No.: 909395-70-6

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Price

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Quantity

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Publications Citing Use of MedChemExpress (MCE) Romosozumab

Phytomedicine. 2026 Jan:150:157669. [Abstract]

Customer Validation & Images

Cell Imaging/Staining

Cell Imaging/Staining

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Human IgG2 kappa

Recommend Isotype Controls

Human IgG2 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

SOST/Sclerostin

In Vivo

Romosozumab (30 mg/kg; s.c. twice a week for 10 weeks) converts trabecular rods into trabecular plates in cynomolgus monkeys^[1].
Romosozumab (3 and 30 mg/kg; s.c. once a week for 6 or 12 months) improves bone mass, architecture, and bone strength, and maintains bone quality at the same time in mature cynomolgus monkeys with 4 months post-ovariectomy^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male cynomolgus monkeys^[1]
Dosage:

30 mg/kg
Administration:

Subcutaneous injection; 30 mg/kg twice a week for 10 weeks
Result:

Increased bone formation and plate-like trabecular morphology, and improved mechanical performance.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

50964 [NCBI]

Accession

Q9BQB4

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG2 kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized SOST Protein, Human can bind Romosozumab. The EC₅₀ for this effect is 12.46 ng/mL.

Chemical Information

CAS No. 909395-70-6
Appearance Liquid
Molecular Weight 146.32 kDa
Color Colorless to light yellow
SMILES

[Romosozumab]
Synonyms

AMG-785; CDP-7851
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

All Cell Imaging/Staining

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Phytomedicine

Schisandrol B inhibits osteoclastogenesis and mitigates estrogen deficiency-induced bone loss by targeting TRAF6-NOX1 pathway. [Abstract]

2026 Jan:150:157669. PMID: 41435606

Romosozumab purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 Jan:150:157669. [Abstract]

Representative images of mature OCs (nuclei≥3) treated with SolB, Denosumab, and Romosozumab (5 μM) and quantitation of mature OCs.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Paik J, Scott LJ. Romosozumab: A Review in Postmenopausal Osteoporosis. Drugs Aging. 2020 Nov;37(11):845-855. [Content Brief]

[2]. Ominsky MS, et al. Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys. J Bone Miner Res. 2017 Apr;32(4):788-801. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Publications (1)
Purity & Documentation
References

1/16

Human IgG2 kappa
1/16

Immobilized SOST Protein, Human can bind Romosozumab. The EC₅₀ for this effect is 12.46 ng/mL.
1/16

Romosozumab purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 Jan:150:157669. [Abstract]

Customer Validation
Representative images of mature OCs (nuclei≥3) treated with SolB, Denosumab, and Romosozumab (5 μM) and quantitation of mature OCs.
1/16

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Romosozumab

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Antibody Inhibitor Library