26 Results for "

skin+aging

" in MedChemExpress (MCE) Product Catalog:
Products (26)

26 Results for "skin+aging" in MCE Product Catalog:

2
5,​7,​4'-​Trimethoxyflavone
5,​7,​4'-​Trimethoxyflavone
0 Images
2 Cited Publications
Cat. No.: HY-N6818
CAS No.: 5631-70-9
Synonyms: TMF
Category:  

Flavonoids Flavones Kaempferia parviflora Wall. ex Baker Plants Disease Research Fields Cancer Zingiberaceae

Target:  

Apoptosis Caspase PARP Endogenous Metabolite CFTR

5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC50 is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .
2
Methylnissolin
Methylnissolin
0 Images
2 Cited Publications
Cat. No.: HY-N2484
CAS No.: 73340-41-7
Synonyms: Astrapterocarpan
Category:  

Cardiovascular Disease Flavonoids Monophenols Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Phenols Plants Disease Research Fields Other Flavonoids

Target:  

PDGFR ERK

Methylnissolin (Astrapterocarpan) is an osteoclast inhibitor with anti-inflammatory, neuroprotective and antioxidant activities. Methylnissolin downregulates the activation of the MAPK and PI3K/AKT pathways, inhibits the phosphorylation of MAPK1 and AKT1, and blocks PDGF-BB-induced phosphorylation of ERK1/2. Methylnissolin reduces the expression and secretion of proinflammatory mediators, decreases intracellular ROS levels, upregulates antioxidant enzymes, and downregulates osteoclastogenesis markers. Methylnissolin is applicable to research related to ischemic stroke, osteoporosis, cardiovascular diseases, skin aging, etc.
2
(+)-Columbianetin
(+)-Columbianetin
0 Images
2 Cited Publications
Cat. No.: HY-N0363
CAS No.: 3804-70-4
Synonyms: (S)-Columbianetin
Category:  

Coumarins Phenylpropanoids Plants Umbelliferae Seriphidium transiliense Disease Research Fields Inflammation/Immunology

Target:  

ERK JNK Collagen TGF-beta/Smad p38 MAPK Reactive Oxygen Species (ROS)

(+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging .
2
(+)-Columbianetin acetate
(+)-Columbianetin acetate
0 Images
2 Cited Publications
Cat. No.: HY-N0363A
CAS No.: 23180-65-6
Synonyms: (S)-Columbianetin acetate
Category:  

other families Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Fungal

(+)-Columbianetin ((S)-Columbianetin) acetate acts as an inhibitor of JNK/ERK. (+)-Columbianetin acetate inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin acetate regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin acetate is applicable to research related to skin aging .
1
Rhamnose
Rhamnose
0 Images
1 Cited Publications
Cat. No.: HY-N1420
CAS No.: 3615-41-6
Synonyms: L-Rhamnose
Category:  

Plants Endogenous metabolite Sweeteners Food Research Monosaccharides other families Microorganisms Disease Research Fields Saccharides Cancer

Target:  

Environmental Pollutants Endogenous Metabolite PKA MMP Interleukin Related

Rhamnose (L-Rhamnose ) is an orally active deoxysugar. Rhamnose can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .
1
Rhamnose monohydrate
Rhamnose monohydrate
0 Images
1 Cited Publications
Cat. No.: HY-N1420A
CAS No.: 10030-85-0
Synonyms: L-Rhamnose monohydrate
Category:  

other families Microorganisms Plants Disease Research Fields Saccharides Cancer Monosaccharides

Target:  

Endogenous Metabolite MMP Interleukin Related PKA

Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .
1
Orobol
Orobol
0 Images
1 Cited Publications
Cat. No.: HY-N3127
CAS No.: 480-23-9
Category:  

Flavonoids Leguminosae Glycine max (L.) merr Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Isoflavones

Target:  

Casein Kinase PI3K VEGFR

Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ) .
H-Gly-Pro-Hyp-OH
H-Gly-Pro-Hyp-OH
0 Images
Cat. No.: HY-A0299
CAS No.: 2239-67-0
Synonyms: Tripeptide 29
Target:  

MMP

Research Areas:  

Inflammation/Immunology

H-Gly-Pro-Hyp-OH is a collagen-derived peptide and also a dipeptidyl peptidase-4 inhibitor.\nH-Gly-Pro-Hyp-OH inhibits the activity of dipeptidyl peptidase-4 in vitro. H-Gly-Pro-Hyp-OH binds to the DNA-binding site of the JUN/FOS complex, blocks the formation of the DNA-JUN/FOS complex, and inhibits transcriptional activity. H-Gly-Pro-Hyp-OH is applicable to research related to skin photoaging, UVB-induced skin aging/photoaging, and thrombosis .
Palmitoyl tripeptide-38
Palmitoyl tripeptide-38
0 Images
Cat. No.: HY-P0104
CAS No.: 1447824-23-8
Target:  

Collagen

Research Areas:  

Metabolic Disease

Palmitoyl tripeptide-38 is a lipopeptide that increases the production of dermal and epidermal collagen, fibronectin, and hyaluronic acid. Palmitoyl tripeptide-38 is used in research related to skin aging (fine lines, wrinkles, reduced skin elasticity, decreased skin water content, uneven skin tone) .
Tetrapeptide-4
Tetrapeptide-4
0 Images
Cat. No.: HY-P5237
CAS No.: 960608-16-6
Target:  

Collagen

Research Areas:  

Others

Tetrapeptide-4 is a synthetic tetrapeptide. Tetrapeptide-4 upregulates hyaluronic acid synthetase, and collagen production in human dermal fibroblasts. Tetrapeptide-4 reduces skin aging, improves skin firmness, elasticity, and appearance, and benefits hair .
Rhamnose monohydrate (Standard)
Rhamnose monohydrate (Standard)
0 Images
Cat. No.: HY-N1420AR
CAS No.: 10030-85-0
Synonyms: L-Rhamnose monohydrate (Standard)
Category:  

other families Microorganisms Plants Saccharides Monosaccharides

Target:  

Reference Standards Endogenous Metabolite MMP Interleukin Related PKA

Rhamnose monohydrate (Standard) is the analytical standard of Rhamnose monohydrate (HY-N1420A). Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .
Acetyl zingerone
Acetyl zingerone
0 Images
Cat. No.: HY-164826
CAS No.: 30881-23-3
Target:  

Interleukin Related Reactive Oxygen Species (ROS) MMP Pyroptosis Ferroptosis Notch Keap1-Nrf2 PINK1/Parkin Mitophagy Caspase Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Acetyl zingerone is an analog of Zingerone (HY-14621). Acetyl zingerone downregulates the expression of ROS metabolism-related genes, fibroblast senescence-related genes, keratinocyte differentiation-related genes, and IL-17A target genes. Acetyl zingerone inhibits the activities of MMP-1, MMP-3, and MMP-12, as well as the activation of NLRP3 inflammasome, pyroptosis (pyroptosis), ferroptosis (ferroptosis), cartilage destruction, and UVA-induced cyclobutane pyrimidine dimer formation. Acetyl zingerone upregulates the expression of collagen, proteoglycan, extracellular matrix glycoprotein, Notch pathway, and GPX4 gene, activates Nrf2 and HO-1, induces extracellular matrix synthesis and PINK1/Parkin-mediated mitophagy (mitophagy), and promotes chondrocyte survival. Acetyl zingerone alleviates the progression of osteoarthritis in mice . Acetyl zingerone can be used in research related to skin aging, inflammatory skin diseases, osteoarthritis, melanoma, and non-melanoma skin cancer .
Sodium Acetylated Hyaluronate
Sodium Acetylated Hyaluronate
0 Images
Cat. No.: HY-164066
CAS No.: 287390-12-9
Target:  

Biochemical Assay Reagents

Research Areas:  

Others

Sodium Acetylated Hyaluronate is an acetylated hyaluronic acid derivative with anti-wrinkle and deep skin penetration properties, which can be used in skin aging research and cosmetic development .
Mannose 6 phosphate
Mannose 6 phosphate
0 Images
Cat. No.: HY-150177
CAS No.: 3672-15-9
Category:  

Human Gut Microbiota Metabolites Endogenous metabolite

Target:  

Drug Intermediate

Mannose 6 phosphate is an essential precursor for mannosyl glycoconjugates, including lipid-linked oligosaccharides (LLO; glucose3mannose9GlcNAc2-P-P-dolichol) used for protein N-glycosylation. Mannose 6 phosphate causes specific LLO cleavage. Mannose 6 phosphate causes specific degradation of G3M9Gn2-P-P-Dol. Complexes containing Mannose 6 phosphate can remodel the dermal collagen network, improve skin biomechanical properties, and reverse visible signs of aging. Mannose 6 phosphate can be used in research related to skin aging .
Safflower oil (from Carthamus tinctorius seed)
Safflower oil (from Carthamus tinctorius seed)
0 Images
Cat. No.: HY-107965
CAS No.: 8001-23-8
Synonyms: Safflower seed oil (from Carthamus tinctorius seed)
Safflower oil (from Carthamus tinctorius seed) is rich in unsaturated fatty acids such as linoleic acid and oleic acid, as well as tocopherols and phenolic compounds, and exhibits antioxidant, anti-aging and blood lipid-regulating effects. Safflower oil (from Carthamus tinctorius seed) inhibits the activities of collagenase and elastase, and exerts antioxidant activity by scavenging free radicals. Linoleic acid in safflower oil (from Carthamus tinctorius seed) reduces blood cholesterol levels. Safflower oil (from Carthamus tinctorius seed) can be applied to research in fields such as skin aging, atherosclerosis, edible oil processing and industrial raw material development .
Hydroxypinacolone retinoate
Hydroxypinacolone retinoate
0 Images
Cat. No.: HY-W442049
CAS No.: 893412-73-2
Synonyms: HPR
Target:  

RAR/RXR

Research Areas:  

Inflammation/Immunology

Hydroxypinacolone retinoate (HPR) is a retinol derivative, which binds directly with retinoic acid receptors (RARs). Hydroxypinacolone retinoate, when used in combination with Retinyl propionate, can be used in anti-skin aging research .
Communic acid
Communic acid
0 Images
Cat. No.: HY-N3612
CAS No.: 2761-77-5
Synonyms: (+)-Communic acid
Category:  

Animals Ketones, Aldehydes, Acids

Target:  

Bacterial Akt MMP

Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC50 of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging .
DL-Syringaresinol
DL-Syringaresinol
0 Images
Cat. No.: HY-N1190
CAS No.: 1177-14-6
Synonyms: (±)-Syringaresinol
Category:  

Lignans Phenylpropanoids Plants Lauraceae Lindera akoensis Hay.

Target:  

p38 MAPK AP-1 Bacterial

DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing MAPK/AP-1 signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv .
Glucoberteroin
Glucoberteroin
0 Images
Cat. No.: HY-N13299
CAS No.: 29611-01-6
Category:  

Plants Brassicaceae Saccharides Degenia velebitica (Degen) Hayek Monosaccharides

Target:  

Endogenous Metabolite

Glucoberteroin is a glucosinolate, which could be isolated from Degenia velebitica. Glucoberteroin inhibits protein glycosylation and carbonylation, decreases the production of carbonyl protein, and contributes to the preventation of skin-aging .
Isoaesculioside D
Isoaesculioside D
0 Images
Cat. No.: HY-N15152
CAS No.: 1184581-59-6
Category:  

Triterpenes Hippocastanaceae Terpenoids Aesculus hippocastanum Plants

Target:  

Others

Isoaesculioside D (compound 3) is an agent for preventing or ameliorating skin aging. Isoaesculioside D exhibits an excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin .
Assay Types