3804-70-4
Chemical Structure
(+)-Columbianetin
Synonym(s): (S)-Columbianetin
- CAS. Nr.: 3804-70-4
- Formula:C14H14O4
- Molecular Weight:246.26
IUPAC Name: (S)-8-(2-hydroxypropan-2-yl)-8,9-dihydro-2H-furo[2,3-h]chromen-2-one
InChIKey: YRAQEMCYCSSHJG-NSHDSACASA-N
SMILES: O=C1C=CC2=CC=C(O[C@H](C(C)(O)C)C3)C3=C2O1
Biological Activity: (+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging[1][2].
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(+)-Columbianetin | 99.30% | (+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging. | ||||||||||||||||||||
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(+)-Columbianetin (Standard) | ≥98% | (+)-Columbianetin (Standard) is the analytical standard of (+)-Columbianetin (HY-N0363). This product is intended for research and analytical applications. (+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging. | ||||||||||||||||||||
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References
- [1]. Jung Hwan Oh, et al. Antiphotoaging Effect of (2′S)-Columbianetin from Corydalis heterocarpa in UVA-Irradiated Human Dermal Fibroblasts. Appl. Sci. 2020, 10(7), 2568.
- [2]. Ahn BN, et al. Protective effect of (2'S)-columbianetin from Corydalis heterocarpa on UVB-induced keratinocyte damage. J Photochem Photobiol B. 2012;109:20-27. [Content Brief]
