6 Results for "

soluble human TNF

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "soluble human TNF" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P99008
CAS No.: 2417175-94-9
Synonyms: IC14
Atibuclimab (IC14), is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab attenuates Lipopolysaccharides (HY-D1056) (LPS)-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Atibuclimab can be used for the research of amyotrophic lateral sclerosis, sepsis, community-acquired pneumonia, or acute lung injury .
loading...
    loading...
Cat. No.: HY-P99830
CAS No.: 1227158-72-6
Synonyms: KH902
Conbercept (KH902) is a recombinant fusion protein composed of VEGFR-1 (second domain) and VEGFR-2 (third and fourth domains) regions fused to human IgG1 Fc. Conbercept is a VEGF inhibitor (IC50 = 8.8 pM) and is a soluble receptor decoy that blocks all isoforms of VEGF-A (Kd = 0.5 pM), VEGF-B (Kd = 8 pM), VEGF-C, and PlGF (Kd = 5 pM). Conbercept has anti-inflammatory effects, can lower the levels of VEGF, TNF-α and IL-6, and reduce the infiltration of inflammatory cells. Conbercept decreases tumor growth in several oncology studies. Conbercept can be used for various eye diseases such as polypoidal choroidal vasculopathy (PCV), diabetic macular edema (DME) and pathologic myopia choroidal neovascularization (pmCNV) .
loading...
    loading...
Cat. No.: HY-P99692
CAS No.: 156679-34-4
Synonyms: p55TNF-R:Ig; Ro 45-2081; TNFR55-IgG1

Target:  

TNF Receptor

Domaines de recherche:  

Inflammation/Immunology

Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble TNF-receptor (p55) linked to the Fc portion of human IgG1 .
loading...
    loading...
Cat. No.: HY-182283
sEH-IN-23 is a soluble epoxide hydrolase inhibitor with a IC50 of 0.8 nM against human sEH and 0.7 nM against murine sEH. sEH-IN-23 inhibits inflammatory factor production mediated by NF-κB activation, reactive oxygen species (ROS) generation, and the release of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α. sEH-IN-23 exhibits anti-inflammatory activity in acute lung injury models. sEH-IN-23 can be used for the research of acute lung injury .
loading...
    loading...
Cat. No.: HY-L161
1,416 compounds

Cytokines are a kind of low molecular soluble proteins synthesized and secreted by immunogen, mitogen or other factors. They have functions of regulating innate and adaptive immune responses, promoting hematopoiesis, stimulating cell activation, proliferation and differentiation. The process of releasing a large number of cytokines is also called “Cytokine storm”, which can cause damage to many tissues and organs in the body. Cytokine is involved in the pathogenesis of many human diseases, including cancer, diabetes, chronic inflammatory diseases and so on. Cytokine inhibitors are a class of essential compounds that act by directly inhibiting the synthesis and release of cytokine or blocking the binding of cytokine to their receptors. Cytokine inhibitors are important compounds for the study of tumor and autoimmune diseases.

MCE designs a unique collection of 1,416 cytokine inhibitors, mainly targeting the receptor interleukin (IL), colony-stimulating factor (CSF), interferon (IFN), tumor necrosis factor (TNF), growth factor (GF) and chemokine, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases and anti-autoimmune diseases compounds.

Cat. No.: HY-P705014
Pureté:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF25; Apoptosis-Mediating Receptor DR3; Prev. TNFRSF12; Protein WSL-1; LARD; Tumor Necrosis Factor Receptor Superfamily Member 25 Deletion Mutant; DDR3; Tumor Necrosis Factor Receptor Superfamily, Member 25; DR3; Death Domain Receptor 3 soluble Form; WSL-LR; Apoptosis Inducing Receptor; TRAMP; Death Receptor Beta; WSL-1; Death Receptor 3; APO-3; Protein WSL; TR3; Apo-3; Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating Chain-Association Membrane Protein); APO3; Tumor Necrosis Factor Receptor Superfamily Member 25; WSL1; Lymphocyte-Associated Receptor Of Death; WSL; Apoptosis-Mediating Receptor TRAMP; TNF Receptor Superfamily Member 25; Apoptosis-Inducing Receptor AIR
Species:  
Human
Source:  
HEK293
loading...
    loading...