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stable activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Acetyl-CoA Carboxylase (1) ADC Payload (1) Adenosine Deaminase (2) Adrenergic Receptor (10) Akt (3) Amino Acid Derivatives (2) Amyloid-β (3) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (21) Antibody-Drug Conjugates (ADCs) (4) Apoptosis (27) Atg4 (1) Aurora Kinase (1) Autophagy (1) Bacterial (30) Bcl-2 Family (2) Bcr-Abl (2) Beta-lactamase (9) Biochemical Assay Reagents (26) c-Kit (1) c-Met/HGFR (1) c-Myc (1) Calcineurin (1) Calcium Channel (2) Casein Kinase (1) Caspase (1) CD20 (1) CD3 (1) CDK (4) Cholinesterase (ChE) (2) COX (4) CXCR (2) Cytochrome P450 (1) Dengue Virus (1) Dipeptidyl Peptidase (8) Disulfidptosis (8) DNA Methyltransferase (1) DNA Stain (1) DNA/RNA Synthesis (8) Dopamine Receptor (2) Drug Derivative (3) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) DYRK (1) E1/E2/E3 Enzyme (2) EGFR (4) Endogenous Metabolite (18) Endothelin Receptor (1) Environmental Pollutants (3) Epoxide Hydrolase (1) ERK (1) Estrogen Receptor/ERR (4) Factor Xa (1) Factor XI (2) FAP (1) Ferroptosis (13) Flavivirus (1) FLT3 (1) Fluorescent Dye (3) Fungal (4) HBV (1) HCV (1) HCV Protease (2) HIF/HIF Prolyl-Hydroxylase (1) HIV (6) HIV Protease (2) HMG-CoA Reductase (HMGCR) (1) Influenza Virus (4) Insecticide (2) Interleukin Related (2) IRE1 (1) Isotope-Labeled Compounds (19) Lactate Dehydrogenase (1) Lipase (2) MDM-2/p53 (3) MELK (1) Microtubule/Tubulin (3) Mitochondrial Metabolism (3) MMP (3) mRNA (1) mTOR (1) Mucin (1) nAChR (1) NF-κB (2) NO Synthase (2) Orthopoxvirus (2) P-glycoprotein (1) P-selectin (1) P2Y Receptor (1) p38 MAPK (1) Parasite (2) PARP (1) PDGFR (1) Phosphodiesterase (PDE) (1) PI3K (1) Polo-like Kinase (PLK) (1) Potassium Channel (1) PPAR (1) Prostaglandin Receptor (1) Radionuclide-Drug Conjugates (RDCs) (1) Ras (2) Reactive Oxygen Species (ROS) (13) Reference Standards (20) SARS-CoV (4) Ser/Thr Protease (1) Sirtuin (1) SOD (3) Sodium Channel (1) Src (2) STING (2) Thrombin (1) TMV (1) Toll-like Receptor (TLR) (3) Topoisomerase (7) Transmembrane Glycoprotein (1) TREM receptor (1) Trk Receptor (1) Tyrosinase (2) VEGFR (1) Virus Protease (4) Wnt (1) Xanthine Oxidase (1) β-catenin (1)
By Research Areas:	Cancer (75) Cardiovascular Disease (20) Endocrinology (4) Infection (61) Inflammation/Immunology (35) Metabolic Disease (26) Neurological Disease (26)
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216

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15917

DL-Dithiothreitol Maximum Cited Publications 42 Publications Verification DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol	Biochemical Assay Reagents Disulfidptosis	Cancer
DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .

HY-114481

Imidazole ketone erastin 45+ Cited Publications IKE	Ferroptosis	Cancer
Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system x_c ^- and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity .

HY-B1369A

Imipenem 30+ Cited Publications N-Formimidoyl thienamycin; MK0787	Antibiotic Bacterial	Infection
Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-B1369

Imipenem monohydrate 30+ Cited Publications N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate	Antibiotic Bacterial	Infection
Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-14291

Vildagliptin 5 Publications Verification LAF237; NVP-LAF 237	Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease Cancer
Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-A0088A

Cefotaxime 10+ Cited Publications Cefotaxim; HR-756	Beta-lactamase Bacterial Antibiotic	Infection Inflammation/Immunology
Cefotaxime, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-124489

2-Hydroxyestradiol 2 Publications Verification	Endogenous Metabolite	Metabolic Disease
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-A0088

Cefotaxime sodium 10+ Cited Publications Cefotaxim sodium; HR-756 sodium	Beta-lactamase Bacterial Antibiotic	Infection Neurological Disease
Cefotaxime (Cefotaxim) sodium, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-B1825

Cefoxitin 10+ Cited Publications	Antibiotic Bacterial Beta-lactamase	Infection
Cefoxitin is a cephalosporin-class antibiotic. Cefoxitin is highly stable against β-Lactamase (HY-P2998). Cefoxitin has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria .

HY-129029

Bisoprolol 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .

HY-129457

FINO2 10+ Cited Publications	Ferroptosis	Cancer
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation .

HY-115470

CLK-IN-T3 3 Publications Verification	CDK DYRK	Cancer
CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC₅₀s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity .

HY-P99038

Odronextamab REGN1979	CD20 CD3	Inflammation/Immunology Cancer
Odronextamab is a stable humanized IgG4 CD20 × CD3 bispecific antibody that binds to CD3 on T cells and CD20 on B cells, triggering anti-tumor activity. Odronextamab is expected to be used in oncology research .

HY-W003607

3-O-Ethyl-L-ascorbic acid	Tyrosinase	Inflammation/Immunology
3-O-Ethyl-L-ascorbic acid is a stable derivative of vitamin C and a cosmetic tyrosinase inhibitor. 3-O-Ethyl-L-ascorbic acid has antioxidant, anti-aging, and skin-whitening activities. 3-O-Ethyl-L-ascorbic acid is often used in the study of cosmetic .

HY-B0076

Bisoprolol hemifumarate 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Bisoprolol hemifumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol hemifumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .

HY-103237

L-Adenosine	Adenosine Deaminase	Neurological Disease
L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an K_i value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation .

HY-B1117

Cefoxitin sodium 10+ Cited Publications MK-306	Bacterial Antibiotic Beta-lactamase	Infection
Cefoxitin sodium (MK-306) is a cephalosporin-class antibiotic. Cefoxitin sodium is highly stable against β-Lactamase (HY-P2998). Cefoxitin sodium has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria .

HY-A0282

L-Ornithine L-aspartate	Amino Acid Derivatives	Metabolic Disease Inflammation/Immunology
L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids with oral activity: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. L-Ornithine L-aspartate also improves mitochondrial functions .

HY-106922A

Sanfetrinem sodium GV104326 sodium	Antibiotic Bacterial	Infection
Sanfetrinem (GV104326) sodium is a beta-lactamase-stable antibiotic. Sanfetrinem sodium has broad-spectrum activity against gram-positive and gram-negative bacteria .

HY-132262

Lorvotuzumab mertansine IMGN-901; BB-1090	Antibody-Drug Conjugates (ADCs)	Cancer
Lorvotuzumab mertansine is an ADC consisting of a humanized N901 monoclonal antibody against CD56 bound to maytansinoid DM1 via a stable disulfide linker. Lorvotuzumab mertansine has antitumor activity .

HY-P1102

TC14012 4 Publications Verification	CXCR HIV	Infection Cancer
TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity .

HY-Y0262B

Sodium oxalate,ACS,99.5% Ethanedioic acid sodium,ACS, 99.5%	Environmental Pollutants Biochemical Assay Reagents Mitochondrial Metabolism	Metabolic Disease Cancer
Sodium oxalate is an orally active dispersant and coordination agent. Sodium oxalate causes mitochondrial dysfunction. Sodium oxalate has catalytic enhancing activity. Sodium oxalate induces stable chronic kidney disease. Sodium oxalate induces highly malignant and undifferentiated breast tumors .

HY-N2459

Peonidin chloride 1 Publications Verification YGM-6 chloride	Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Peonidin chloride is an anthocyanin compound found in plants such as grapes and purple-fleshed sweet potatoes. Peonidin chloride alone exerts no stable inhibitory effect on LPS (HY-D1056)-mediated inflammatory gene expression. The acylated form of Peonidin chloride exhibits antimutagenic activity .

HY-100768

HTHQ 2 Publications Verification 1-O-hexyl-2,3,5-trimethylhydroquinone; HX-1171; BTT-105	Reactive Oxygen Species (ROS)	Cancer
HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) is a potent lipophilic phenolic antioxidant. HTHQ has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS) and scavenging ROS to form more stable free radicals .

HY-108658

MRS2500 tetraammonium	P2Y Receptor	Cardiovascular Disease
MRS2500 tetraammonium is a potent, selective and stable antagonist of the P2Y1 receptor (K_i=0.78 nM for recombinant human P2Y1 receptor). MRS2500 tetraammonium inhibits the ADP-induced aggregation of human platelets with an IC₅₀ value of 0.95 nM. Antithrombotic activity .

HY-B1369R

Imipenem monohydrate (Standard) N-Formimidoyl thienamycin monohydrate (Standard); MK0787 monohydrate (Standard)	Reference Standards Antibiotic Bacterial	Infection
Imipenem (monohydrate) (Standard) is the analytical standard of Imipenem (monohydrate). This product is intended for research and analytical applications. Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-101006

Methyl 2,5-dihydroxycinnamate	EGFR	Cancer
Methyl 2,5-dihydroxycinnamate is an erbstatin analog and a stable, potent inhibitor of EGFR kinase activity .

HY-106583

Piroxicam cinnamate Cinnoxicam; SPA-S-510; Sinartol	COX	Inflammation/Immunology
Piroxicam cinnamate (Cinnoxicam) is a cyclooxygenase (COX) inhibitor, with anti-inflammatory activity. Piroxicam cinnamate is stable under gastric conditions, can be used for inflammatory-degenerative osteoarticular diseases, rheumatic disorders, and varicocele (VC) associated oligoasthenospermia research .

HY-112711

LV-320	Atg4 Autophagy	Cancer
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC₅₀ of 24.5 μM and a K_d of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo .

HY-128775

JHU395	Drug Derivative	Cancer
JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST .

HY-114333

Octyl-α-ketoglutarate 1-Octyl 2-oxopentanedioate	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease Cancer
Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD .

HY-129242

Tempone 4-Oxo-Tempo	SOD	Others
Tempone (4-Oxo-Tempo) is a stable water-soluble nitro radical. Tempone is widely used as a contrast agent for metabolic activity and hypoxic sensitivity in electron spin resonance spectroscopy, magnetic resonance imaging and dynamic nuclear polarization. Tempone reduces superoxide radicals by mimicking the activity of superoxide dismutase (SOD), thereby reducing the formation of hydroxyl radicals and peroxynitrites. Tempone can be used in the study of ischemia-reperfusion injury and acute renal failure .

HY-120937

DC4 Crosslinker	Biochemical Assay Reagents	Others
DC4 Crosslinker is a stable crosslinking reagent with improved activity and solubility. DC4 Crosslinker is labile cleavable with collision-induced dissociation (CID), that will be fragmented into four rearrange products containing mobilized protons .

HY-15917S2

DL-Dithiothreitol-d6 DTT-d₆	Isotope-Labeled Compounds Disulfidptosis	Cancer
DL-Dithiothreitol-d₆ is the deuterated form of DL-Dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond .

HY-176892

Papaveroline	Src	Neurological Disease
Papaveroline is an orally active Fyn tyrosine kinase inhibitor. Papaveroline stably binds to the active site of Fyn tyrosine kinase via hydrogen bonding and hydrophobic interactions, thereby inhibiting kinase activity associated with the pathogenesis of Alzheimer's disease. Papaveroline can be used for the research of Alzheimer's disease .

HY-A0088AR

Cefotaxime (Standard) Cefotaxim (Standard); HR-756 (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection Inflammation/Immunology
Cefotaxime (Standard) is the analytical standard of Cefotaxime. This product is intended for research and analytical applications. Cefotaxime, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-D1993

ATTO 647 NHS ester	Fluorescent Dye HIV	Infection
ATTO 647 NHS ester is a fluorescent label targeting free amino groups. ATTO 647 NHS ester can undergo a nucleophilic reaction with the free amino groups of EF-C peptide via its activated carboxylic acid group to form a stable covalent conjugate. ATTO 647 NHS ester-labeled nanofibers not only retain retroviral transduction-enhancing activity but also maintain stable fluorescent signals in both buffer and cell culture systems. ATTO 647 NHS ester is suitable for detection applications including fluorescence spectroscopy, microscopy and flow cytometry. ATTO 647 NHS ester has been used in studies related to HIV-1 infection .

HY-W654101

Cefotaxime-d3 Cefotaxim-d₃; HR-756-d₃	Isotope-Labeled Compounds Antibiotic Bacterial	Infection
Cefotaxime-d3 is the deuterium labeled Cefotaxime (HY-A0088A). Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-169847

ZK-806450	SARS-CoV Dengue Virus	Infection
ZK-806450 is a compound with antiviral activity. ZK-806450 has a high binding potential to the allosteric binding site of the SARS-CoV-2 3CL protease. ZK-806450 can also specifically and stably bind to the GAG site of the dengue virus envelope protein .

HY-P11170

D-Cateslytin	Fungal	Infection
D-Cateslytin is an antimicrobial peptide that exhibits potent inhibition activity against Candida albicans (MIC = 2.9 μM). D-Cateslytin can rapidly enter C. albicans, and shows no cytotoxicity to human gingival fibroblasts, and is stable in saliva. D-Cateslytin can be used for research on Candida albicans related diseases, such as oral candidosis .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-106922

Sanfetrinem GV104326	Antibiotic Bacterial	Infection
Sanfetrinem (GV104326) is a β-lactamase-stable antibiotic. Sanfetrinem has broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria .

HY-E70331

Acid Stable Protease	Endogenous Metabolite	Others
Acid Stable Protease is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-15917S

DL-Dithiothreitol-d10 DTT-d₁₀	Isotope-Labeled Compounds Disulfidptosis	Cancer
DL-Dithiothreitol-d₁₀ is the deuterated form of DL-Dithiothreitol. DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .

HY-14291A

Vildagliptin dihydrate LAF237 dihydrate; NVP-LAF 237 dihydrate	Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease Cancer
Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-105213

YM-17K MC-352	Antibiotic Bacterial	Infection
YM-17K (MC-352) is a macrolide antibiotic. YM-17K exhibits antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and anaerobic bacteria. YM-17K exhibits stable activity in serum and is less affected by pH values .

HY-A0088S

Cefotaxime-d3 sodium Cefotaxim-d3 sodium; HR-756-d3 sodium	Isotope-Labeled Compounds Beta-lactamase Bacterial Antibiotic	Infection
Cefotaxime-d₃ (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-P1102A

TC14012 TFA	CXCR HIV	Infection Cancer
TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 TFA is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has anti-HIV activity and anti-cancer activity .

HY-120829

Bisoprolol fumarate	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Bisoprolol fumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol fumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .

HY-14291S1

Vildagliptin-d7 LAF237-d₇; NVP-LAF 237-d₇	Isotope-Labeled Compounds Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease
Vildagliptin-d₇ is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

Cat. No.	Product Name

HY-L167

Boronic Acid Compound Library

164 compounds

Boric acid is a stable and usually non-toxic group widely used in modern synthesis to form C-C and C-heteroatom bonds. Boric acid exhibits exquisite reversible coordination characteristics and can be explored as a molecular construction tool, with specific mechanisms for controlling the structure and biological characteristics of bioconjugates. Boric acid has various activities, such as anticancer, antibacterial, and antiviral activities. In drugs, boric acid mainly exists in the form of arylboronic acid. In addition to this form, heterocycles containing boric acid, such as pyridine, pyrrole, and indole derivatives, are also very useful in pharmaceutical chemistry. Molecular modification by introducing boric acid groups into bioactive molecules has been shown to alter selectivity, physicochemical, and pharmacokinetic characteristics, and improve existing activity.

MCE designs a unique collection of 164 boronic acid compounds. It is a good tool to be used for research on cancer and other diseases.

HY-L935

Molecular Glue POI binding Fragment library

1039 compounds

POI (Protein of Interest) refers to the target protein, namely the disease-causing protein or key functional protein that undergoes degradation or functional modulation in molecular glue-mediated processes. The Molecular Glue POI Library consists of a series of fragments that can specifically bind to different types of POIs. As key components of molecular glues, these ligands form stable interactions with target proteins, laying the foundation for molecular glues to induce the interaction between POIs and E3 ubiquitin ligases. The covered POIs include various types such as cancer-associated GSPT1, androgen receptors, and abnormally aggregated proteins linked to neurodegenerative diseases.

This fragment library can be applied to the screening and optimization of targeted protein degraders. By screening ligands with high affinity and strong selectivity for specific POIs from the library, core structures can be identified to develop novel molecular glues. For instance, optimization of ligands targeting GSPT1 has yielded molecular glue degraders with enhanced degradation activity. Since many POIs are difficult to drug due to the lack of traditional small-molecule binding pockets, some ligands in the POI Ligand Library can modulate such POIs by inducing protein-protein interactions, thereby further expanding the scope of drug discovery for undruggable targets.

MCE has compiled a POI Fragment Library comprising thousands of POI fragments with molecular weights ranging from 150 to 400. This compound library can be widely applied in Molecular Glue research and development.

Cat. No.	Product Name	Type

HY-177434

Precemtabart tocentecan

Precem-TcT; M 9140

Fluorescent Dye

Precemtabart tocentecan (Precem-TcT; M 9140) is an anti-CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) antibody-drug conjugate (ADC). Precemtabart tocentecan consists of a tumor-specific anti-CEACAM5 monoclonal antibody Precemtabart (HY-P990940), a highly hydrophilic and stable cleavable β-glucuronide linker, and a topoisomerase 1 inhibitor payload Exatecan (HY-13631), and the drug-linker conjugate for ADC is Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179). Precemtabart tocentecan inhibits the growth of CEACAM5-positive cancer cells. Precemtabart tocentecan exhibits significant antitumor activity in CEACAM5-expressing xenograft models. Precemtabart tocentecan can be used for the study of CEACAM5-expressing advanced solid tumors, especially mCRC .

HY-177442

DS-3939a

DS-3939

Fluorescent Dye

DS-3939a (DS-3939) is an anti-TA-MUC1 (tumor-associated mucin-1) antibody-drug conjugate (ADC). DS-3939a consists of a humanized anti-TA-MUC1 IgG1 monoclonal antibody Gatipotuzumab ( HY-P99634), a stable and cleavable tetrapeptide-based linker (Gly-Gly-Phe-Gly), and a DNA topoisomerase I inhibitor payload (DXd) (HY-13631D), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). DS-3939a inhibits the growth of TA-MUC1-positive cancer cells (CFPAC-1, NCI-H2110) by inducing DNA damage and apoptosis. DS-3939a exhibits significant antitumor activity in a variety of TA-MUC1-expressing advanced solid tumors. DS-3939a can be used for the study of TA-MUC1-expressing advanced cancers .

HY-164729

FZ-AD005

Fluorescent Dye

FZ-AD005 is a DLL3-targeting antibody-drug conjugate (ADC) with high selectivity, composed of the anti-DLL3 antibody FZ-A038 (HY-P990896), a dipeptide linker (Val-Ala), and DXd (HY-13631D). The K_d value of FZ-AD005 for human DLL3 ranges from 13.29 to 58.3 pmol/L. After binding to DLL3 on the cell surface, FZ-AD005 mediates endocytosis, and the payload DXd is released via cleavage by lysosomal cathepsins. DXd inhibits topoisomerase TopI to induce double-strand DNA breaks, cell cycle arrest and apoptosis, and FZ-AD005 exhibits bystander killing activity against adjacent DLL3-negative cells. FZ-AD005 shows stable circulation in vivo, has good tolerance and acceptable pharmacokinetic profiles in rats and cynomolgus monkeys, and effectively inhibits the growth of DLL3-expressing tumor cells. FZ-AD005 serves as a promising candidate molecule for research on small cell lung cancer and human neuroendocrine prostate cancer .

HY-D0163

Methyl Green

1 Publications Verification

Fluorescent Dye

Methyl Green is a non-intercalating fluorescent labeling agent that selectively binds to the major groove of DNA. Methyl Green electrostatically interacts with the major groove of DNA through positively charged groups, exhibiting key activities such as high affinity, resistance to photobleaching, and stable fluorescence emission. Methyl Green can be directly measured by microscopy and flow cytometry, with peaks at 633 and 677 nm. Methyl Green can be used for fluorescent labeling of the nuclei of embryonic tissues or cells, or DNA staining and cell activity detection in gel electrophoresis[1][2][3].

HY-D1993

ATTO 647 NHS ester

Fluorescent Dye

ATTO 647 NHS ester is a fluorescent label targeting free amino groups. ATTO 647 NHS ester can undergo a nucleophilic reaction with the free amino groups of EF-C peptide via its activated carboxylic acid group to form a stable covalent conjugate. ATTO 647 NHS ester-labeled nanofibers not only retain retroviral transduction-enhancing activity but also maintain stable fluorescent signals in both buffer and cell culture systems. ATTO 647 NHS ester is suitable for detection applications including fluorescence spectroscopy, microscopy and flow cytometry. ATTO 647 NHS ester has been used in studies related to HIV-1 infection .

HY-D2477

Sulfo-QSY21-NHS	Fluorescent Dye
Sulfo-QSY21-NHS is a fluorescent dye, which contains a NHS group that can react with amine groups (-NH2) in proteins or other molecules to form stable amide bonds. Sulfo-QSY21-NHS can be used in the synthesis of activity-based probes (ABPs) .

Cat. No.	Product Name	Type

HY-15917

DL-Dithiothreitol Maximum Cited Publications 42 Publications Verification DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol	Biochemical Assay Reagents
DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .

HY-D0175

3-Aminopropyltriethoxysilane

2 Publications Verification

γ-Aminopropyltriethoxysilane; APTES

Biochemical Assay Reagents

3-Aminopropyltriethoxysilane (APTES) acts as a strong glue to immobilize biomolecules such as antibodies and enzymes to silicon and silicon derivatives such as silicon nitride (Si₃N₄)) on. 3-Aminopropyltriethoxysilane also acts as a spacer, providing biomolecules with more spatial freedom during immobilization for higher specific activity. 3-Aminopropyltriethoxysilane can form a more stable, sensitive, and highly biocompatible bioanalytical platform by immobilizing biomolecules onto some solid materials, electrode materials, nanomaterials, and nanocomposites .

HY-130777A

AMP-PNP lithium hydrate

3 Publications Verification

Adenylyl imidodiphosphate lithium hydrate

Biochemical Assay Reagents

AMP-PNP (Adenylyl imidodiphosphate) lithium hydrate is a non-hydrolyzable ATP analog. AMP-PNP lithium hydrate binds to ATP binding sites competely but is not hydrolyzed by enzymes, providing stable experimental conditions for studying ATP-dependent processes. AMP-PNP lithium hydrate can also be used to study enzyme activity, kinase regulation, DNA/RNA metabolism, ion channel function, and protein complex assembly .

HY-W002004

4-Amino-TEMPO

4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl

Biochemical Assay Reagents

4-Amino-TEMPO (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl) is a stable nitroxide radical and N-nucleophile based on TEMPO. 4-Amino-TEMPO has superoxide dismutase-mimetic activity, can protect cells from oxidative damage, and has radioprotective effects. 4-Amino-TEMPO is widely used in fields such as biomedicine, materials science, and industrial production. 4-Amino-TEMPO can be used as a spin label to detect free radicals, an oxidation catalyst in industrial production, and an antioxidant stabilizer for polymers, among others .

HY-160113

Sodium phosphate buffer 0.02 M, pH 6.9

Biochemical Assay Reagents

Sodium phosphate buffer 0.02 M, pH 6.9 is a commonly used aqueous biological buffer that maintains a stable pH value. Sodium phosphate buffer 0.02 M, pH 6.9 is often used in enzyme activity assays, such as α-amylase assays. Sodium phosphate buffer 0.02 M, pH 6.9 is prepared by mixing disodium hydrogen phosphate (Na₂HPO₄) (HY-B2243) and sodium dihydrogen phosphate (NaH₂PO₄) (HY-Y0308) to a total concentration of 0.02 M .

HY-153229

Firefly luciferase mRNA-LNP

1 Publications Verification

Biochemical Assay Reagents

Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-Y0262B

Sodium oxalate,ACS,99.5% Ethanedioic acid sodium,ACS, 99.5%	Biochemical Assay Reagents
Sodium oxalate is an orally active dispersant and coordination agent. Sodium oxalate causes mitochondrial dysfunction. Sodium oxalate has catalytic enhancing activity. Sodium oxalate induces stable chronic kidney disease. Sodium oxalate induces highly malignant and undifferentiated breast tumors .

HY-158224

Silk Fibroin Methacryloyl

FibMA

Biochemical Assay Reagents

Silk Fibroin Methacryloyl (FibMA) is methacrylated silk fibroin with excellent biocompatibility, stable mechanical properties and good processing properties, and was selected as the substrate for multifunctional microneedle (MN) patches. . MN patches made of Silk Fibroin Methacryloyl exhibit excellent biocompatibility, sustained drug release, pro-angiogenic, antioxidant and antibacterial properties depending on the specific drug encapsulated . Silk Fibroin Methacryloyl needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.

HY-101410A

SDMA (p-hydroxyazobenzene-p′-sulfonate)

Symmetric dimethylarginine (p-hydroxyazobenzene-p′-sulfonate); NG,NG'-Dimethyl-L-arginine (p-hydroxyazobenzene-p′-sulfonate)

Biochemical Assay Reagents

SDMA p-hydroxyazobenzene-p′-sulfonate is the p-hydroxyazobenzene-p′-sulfonate salt form of SDMA (HY-101410). SDMA p-hydroxyazobenzene-p′-sulfonate is an endogenous inhibitor of nitric oxide synthase (NO synthase) activity. SDMA p-hydroxyazobenzene-p′-sulfonate is an activator for NF-κB, and promotes the expression of IL-6 and TNF-α. SDMA p-hydroxyazobenzene-p′-sulfonate is stable in serum and plasma, and can be used as a kidney biomarker of hepatic and renal dysfunction .

HY-W002328

Pyrazole-3-carboxylic acid

Biochemical Assay Reagents

Pyrazole-3-carboxylic acid is an alternative anchoring group to carboxylic acid in phthalocyanine dyes. Pyrazole-3-carboxylic acid shows flexible coordination modes when coordinates with metal ions. Pyrazole-3-carboxylic acid can chelate to metal ions and form very stable complexes through its N and O atoms. Pyrazole-3-carboxylic acid can be used to synthesize derivatives that possess antibacterial, anti-inflammatory, ulcerogenic liability and antiproliferative activities .

HY-112111A

Poly-L-Glutamic acid (MW 100000)	Biochemical Assay Reagents
Poly-L-Glutamic acid (MW 100000) is a biopolymer composed of L-glutamic acid units. It has the activity of forming stable water-soluble complexes with metal ions and is widely used in the manufacture of biodegradable materials.

HY-W803862

Tripotassium citrate	Biochemical Assay Reagents
Tripotassium citrate is a compound containing potassium and citrate ions that has activity as a buffer, able to maintain a stable pH required for many enzymatic reactions and biochemical processes. Tripotassium citrate can be used as a buffer in enzyme assays to ensure the validity of experimental conditions.

HY-W127719

Photobiotin acetate

Biochemical Assay Reagents

Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Target	Research Area

HY-P1146

Semax 1 Publications Verification	Amyloid-β	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu ²⁺. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia .

HY-P1102

TC14012 4 Publications Verification	CXCR HIV	Infection Cancer
TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity .

HY-P10626

Nanodisc scaffold peptide NSPr	Peptides	Others
Nanodisc scaffold peptide (NSPr) is an amphipathic double-helical peptide that stabilizes membrane proteins by mimicking their natural environment, allowing them to remain stable and active in detergent-free aqueous solutions. Nanodisc scaffold peptide can be used to construct a universal tool for high-throughput stabilization of membrane proteins, facilitating modern biological research .

HY-P1146A

Semax acetate 1 Publications Verification	Amyloid-β	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu ²⁺. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia .

HY-W006886

Fmoc-(R)-2-(7-octenyl)Ala-OH	Amino Acid Derivatives	Others
Fmoc-(R)-2-(7-octenyl) Ala-OH is an unnatural Fmoc-protected amino acid and modification module. Fmoc-(R)-2-(7-octenyl) Ala-OH serves as a key building block for all-hydrocarbon cross-linking modification of antimicrobial peptides, and facilitates the generation of stapled peptide derivatives. When introduced into specific sites of the parent peptide, Fmoc-(R)-2-(7-octenyl) Ala-OH effectively increases the α-helix content of the peptide chain, thereby significantly enhancing its antimicrobial activity and proteolytic stability. Fmoc-(R)-2-(7-octenyl) Ala-OH is widely used in research on bacterial infections and the development of related antimicrobial agents . Stapled peptide is a specially chemically modified polypeptide. It locks the peptide chain into a stable α-helical structure by introducing a "staple"-like chemical bridge (usually an all-carbon backbone) at specific positions of the peptide chain.

HY-P11170

D-Cateslytin	Fungal	Infection
D-Cateslytin is an antimicrobial peptide that exhibits potent inhibition activity against Candida albicans (MIC = 2.9 μM). D-Cateslytin can rapidly enter C. albicans, and shows no cytotoxicity to human gingival fibroblasts, and is stable in saliva. D-Cateslytin can be used for research on Candida albicans related diseases, such as oral candidosis .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-P11012

EK1	SARS-CoV	Infection
EK1 is a peptide-based fusion inhibitor of coronaviruses (CoVs) with broad spectrum inhibition to a number of CoV species. EK1 shows substantially improved pan-CoV fusion inhibitory activity. EK1 potently inhibits SARS-CoV-2. EK1 can form a stable six-helix bundle (6HB) structure with both short α-hCoV and long β-hCoV N-terminal heptad repeats .

HY-P1102A

TC14012 TFA	CXCR HIV	Infection Cancer
TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 TFA is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has anti-HIV activity and anti-cancer activity .

HY-P5924A

D-K6L9	Bacterial	Infection
D-K6L9 shows antimicrobial and antibiofilm activities against P. aeruginosa from cystic fibrosis patients. D-K6L9 is stable and resistant to degradation by cystic fibrosis sputum proteases and will not induce bacterial resistance .

HY-P5924

L-K6L9	Bacterial	Infection
L-K6L9 shows antimicrobial and antibiofilm activities against P. aeruginosa from cystic fibrosis patients. L-K6L9 is stable and resistant to degradation by cystic fibrosis sputum proteases and will not induce bacterial resistance .

HY-P10860

cMCoFx1	Factor Xa	Cardiovascular Disease
cMCoFx1 is a potent and selective FXIIa cyclic peptide inhibitor. cMCoFx1 has high binding affinity (K_D: 900 pM) and inhibitory activity (K_i: 370 pM) for FXIIa. cMCoFx1 can effectively inhibit endogenous clotting pathways, and cMCoFx1 is stable in serum and non-cytotoxic .

HY-106428

Icrocaptide ITF1697	P-selectin	Cardiovascular Disease Inflammation/Immunology
Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca ²⁺-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits P-selectin and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99038

Odronextamab REGN1979	CD20 CD3	Inflammation/Immunology Cancer
Odronextamab is a stable humanized IgG4 CD20 × CD3 bispecific antibody that binds to CD3 on T cells and CD20 on B cells, triggering anti-tumor activity. Odronextamab is expected to be used in oncology research .

HY-P991211

Bemiltenase alfa STSP-0601	Factor XI	Cardiovascular Disease
Bemiltenase alfa is a hemostatic agent targeting coagulation factor X (FX). Bemiltenase alfa activates FX and promotes the conversion of prothrombin to thrombin, and thrombin can further transform fibrinogen into fibrin, forming a stable blood clot, thus exerting hemostatic activity. Bemiltenase alfa is promising for research of bleeding symptoms with hemophilia .

HY-P991029

Sutacimig HMB-001	Thrombin Ser/Thr Protease TREM receptor	Cardiovascular Disease
Sutacimig (HMB-001) is a humanized antibody of the (H-γ4_L-κ)_(H-γ4_L-κ) format that targets FⅦa/TREML1. One arm of Sutacimig binds to endogenous FVIIa, thereby prolonging the half-life of FVIIa and increasing its accumulation in the bloodstream, while the other arm binds to TLT-1, which is exclusively expressed on the surface of activated platelets. This localizes endogenous FVIIa to activated platelets, further enhancing the activity of FVIIa. Sutacimig enhances Thrombin generation, fibrin formation, and the formation of stable fibrin-platelet networks at sites of vascular injury. Sutacimig can be used in studies related to Glanzmann thrombasthenia .

HY-P991213

Nonacog gamma Rixubis	Factor XI	Cardiovascular Disease
Nonacog gamma is a coagulation factor IX (FIX) supplement. Nonacog gamma activates coagulation factor X (FX), promotes the generation of thrombin, and then converts fibrinogen into fibrin, forming a stable blood clot to exert hemostatic activity. Nonacog gamma is promising for research of hemophilia B .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0215

Acetylcysteine Maximum Cited Publications 661 Publications Verification N-Acetylcysteine; N-Acetyl-L-cysteine; NAC	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent that can cross the blood-brain barrier, which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-B1369

Imipenem monohydrate 30+ Cited Publications N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-124489

2-Hydroxyestradiol 2 Publications Verification	Classification of Application Fields Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-B1306

4-Aminohippuric acid 4 Publications Verification p-Aminohippuric acid	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Others
4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu ²⁺, Fe ³⁺, Hg ²⁺) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .

HY-N2459

Peonidin chloride 1 Publications Verification YGM-6 chloride	Structural Classification Classification of Application Fields Plants Food Research Anthocyans Flavonoids Paeonia lactiflora Pall. Phenols Polyphenols Pigments Paeoniaceae Disease Research Fields Source Classification Cancer	Interleukin Related
Peonidin chloride is an anthocyanin compound found in plants such as grapes and purple-fleshed sweet potatoes. Peonidin chloride alone exerts no stable inhibitory effect on LPS (HY-D1056)-mediated inflammatory gene expression. The acylated form of Peonidin chloride exhibits antimutagenic activity .

HY-B1369R

Imipenem monohydrate (Standard) N-Formimidoyl thienamycin monohydrate (Standard); MK0787 monohydrate (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Antibiotic Bacterial
Imipenem (monohydrate) (Standard) is the analytical standard of Imipenem (monohydrate). This product is intended for research and analytical applications. Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-135700

Mevalonolactone	Structural Classification Microorganisms Other Phenylpropanoids Phenylpropanoids Source Classification	Calcineurin Ras HMG-CoA Reductase (HMGCR)
Mevalonolactone is an intermediate metabolite in the eukaryotic mevalonate pathway, serving as the stable δ-lactone form of mevalonate with oral activity. Mevalonolactone exhibits binding affinity for ZNF384 (K_a = 12.6 μM) and inhibitory activity against aconitase (aconitase). Mevalonolactone promotes the nuclear localization of ZNF384 and enhances its binding to the GGPPS promoter. Mevalonolactone induces insulin resistance, disrupts glucose and lipid metabolism, enhances the isoprenylation of K-Ras, and inhibits the activation of the insulin signaling pathway. Mevalonolactone inhibits polypeptide synthesis of HMG-CoA reductase in isolated rat hepatocytes, promotes its degradation, and reduces its enzymatic activity. Mevalonolactone impairs mitochondrial function in rat brains. Mevalonolactone promotes the development of metabolically unhealthy obesity. Mevalonolactone can be used in research related to metabolically abnormal obesity, mevalonic aciduria, HMGCR-related limb-girdle myopathy, and statin-induced myopathy .

HY-B0215R

Acetylcysteine (Standard) N-Acetylcysteine (Standard); N-Acetyl-L-cysteine (Standard); NAC (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis
Acetylcysteine (Standard) is the analytical standard of Acetylcysteine. This product is intended for research and analytical applications. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor . Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases . Acetylcysteine induces cell apoptosis . Acetylcysteine also has anti-influenza virus activities . In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-B1306R

4-Aminohippuric acid (Standard) p-Aminohippuric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Biochemical Assay Reagents
4-Aminohippuric acid (p-Aminohippuric acid) (Standard) is the analytical standard of 4-Aminohippuric acid (HY-B1306). This product is intended for research and analytical applications. 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu ²⁺, Fe ³⁺, Hg ²⁺) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .

HY-N8693

Withanoside IV	Structural Classification Withania somnifera Solanaceae Plants Steroids Source Classification	COX Amyloid-β Sirtuin Reactive Oxygen Species (ROS) Apoptosis SARS-CoV
Withanoside IV is an orally active, blood-brain barrier-permeable withanolide derivative. Withanoside IV specifically binds to the Sudlow I site of HSA, induces secondary structural changes in HSA, and forms stable HSA complexes. Withanoside IV inhibits the enzymatic activity of COX-2. Withanoside IV induces axonal regeneration, peripheral nervous system myelination and increased axonal density in spinal cord tissue, reduces reactive gliosis-related changes, and improves hindlimb motor function. Withanoside IV binds to amyloid-β 1-42 to inhibit its aggregation, induces neurite outgrowth and synapse reconstruction, repairs damaged axons and dendrites, enhances mitochondrial biogenesis, exerts neuroprotective effects via the BDNF and SIRT1 signaling pathways, reduces ROS production and neuronal apoptosis, and ameliorates memory deficits. Withanoside IV inhibits the activity of the SARS-CoV-2 main protease. Withanoside IV can be used in research related to spinal cord injury, Alzheimer's disease, and coronavirus disease 2019 (COVID-19) .

HY-N15419

Acutumidine	Alkaloids Other Alkaloids Plants Menispermaceae Hypserpa nitida Miers Source Classification	HBV
Acutumidine (compound 4) is an alkaloid with anti-HBV activity that can be isolated from Hypserpa nitida Miers. Acutumidine inhibits the production of HBsAg in Hep G2.2.15 cells stably transfected with HBV genome with an IC₅₀ value of 2.023 mM .

HY-124489R

2-Hydroxyestradiol (Standard)	Structural Classification Phenols Polyphenols Endogenous metabolite Steroids Source Classification	Endogenous Metabolite Reference Standards
2-Hydroxyestradiol (Standard) is the analytical standard of 2-Hydroxyestradiol. This product is intended for research and analytical applications. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-N2459R

Peonidin chloride (Standard) YGM-6 chloride (Standard)	Structural Classification Anthocyans Flavonoids Microorganisms Paeonia lactiflora Pall. Phenols Polyphenols Plants Paeoniaceae Source Classification	Reference Standards Interleukin Related
Peonidin chloride (Standard) is the analytical standard of Peonidin chloride (HY-N2459). This product is intended for research and analytical applications. Peonidin chloride is an anthocyanin compound found in plants such as grapes and purple-fleshed sweet potatoes. Peonidin chloride alone exerts no stable inhibitory effect on LPS (HY-D1056)-mediated inflammatory gene expression. The acylated form of Peonidin chloride exhibits antimutagenic activity.

HY-W753779

8-Hydroxygenistein 8-OHG	Flavonoids Flavones Leguminosae Glycine max (L.) merr Plants Source Classification	Reactive Oxygen Species (ROS) NO Synthase
8-Hydroxygenistein (8-OHG) is an antioxidant that can effectively scavenge nitric oxide (NO) and superoxide anion (O₂⁻). 8-Hydroxygenistein belongs to ortho-dihydroxy isoflavones (ODI) and is abundantly present in dark soy sauce and light soy sauce. Its antioxidant activity is stronger than that of its parent compound genistein (HY-14596). The content of 8-Hydroxygenistein is positively correlated with the antioxidant capacity of soy sauce (r = 0.959), and it remains highly stable even after being heated in boiling water for 60 minutes. During the brewing and storage of soy sauce, 8-Hydroxygenistein effectively prevents oxidative damage, making it promising for use in food antioxidant research.

HY-N16742

Hydrangeifolin I	Structural Classification Sapindaceae Coumarins Phenylpropanoids Plants Acer nikoense Maxim. Source Classification	Drug Derivative
Hydrangeifolin I is a natural phenolic compound.

HY-N17632

Moracin G	Structural Classification Phenols Polyphenols Plants Moraceae Morus alba Linn. Source Classification	Estrogen Receptor/ERR Akt MELK COX Apoptosis
Moracin G is a plant-derived kinase modulator and receptor ligand that forms stable bindings with multiple key proteins (AKT1, COX2 and Estrogen receptor 1) and competitively inhibits the activity of specific kinases. By binding to MELK to disrupt cell cycle regulation, Moracin G impairs the survival and proliferation of cancer cells, induces cancer cell apoptosis, and thereby exerts anti-tumor potential. Moracin G can be used in research related to periodontitis and breast cancer .

HY-N14926

Oganomycin GB	Natural Products Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial
Oganomycin GB is Streptomyces str. oganonensis Y-G 19Z and Oganomycin A is produced when p-hydroxycinnamate sodium salt is added to the fermentation medium. Under the action of D-amino acid oxidase, A generates glutaryl derivative, GA; A and GA were converted to B and GB by acid hydrolysis to remove sulfate esters. The effect of B on d-amino acid oxidase was also changed to GB. A and B were more stable than A and B of cemycin, and had stronger effect against Gram-positive and Gram-negative bacteria than Gram-positive bacteria. The antibacterial activity of A and B was higher than that of GA and GB .

Cat. No.	Product Name	Chemical Structure

HY-W749209

Acetic acid-13C2 sodium
Acetic acid-13C2 is a stable isotope labeled compound with biomarker and metabolic tracking activity. Acetic acid-13C2 is often used in biochemical research for the analysis of metabolic pathways. Acetic acid-13C2 is also used in medical imaging and compound development to improve the understanding of biological processes.

HY-B0215S

Acetylcysteine-d3

Acetylcysteine-d₃ is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-W750796

Butyric acid-13C4 sodium

Butyric acid-13C4 sodium (Butanoic acid-13C4 sodium) is a stable isotope labeled compound with the activity of promoting cell proliferation and regulating gene expression. Butyric acid-13C4 sodium can be used in metabolic research and compound development to help scientists gain a deeper understanding of the role of short-chain fatty acids in organisms. Butyric acid-13C4 sodium also plays an important role in nutrition and intestinal health research, especially in the regulation of probiotic function and intestinal microbiota.

HY-15917S2

DL-Dithiothreitol-d6
DL-Dithiothreitol-d₆ is the deuterated form of DL-Dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond .

HY-W654101

Cefotaxime-d3
Cefotaxime-d3 is the deuterium labeled Cefotaxime (HY-A0088A). Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-129029S

Bisoprolol-d5
Bisoprolol-d₅ is the deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .

HY-B1306S

4-Aminohippuric acid-d4

4-Aminohippuric acid-d₄ (p-Aminohippuric acid-d₄) is the deuterium labeled 4-Aminohippuric acid (HY-B1306). 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu ²⁺, Fe ³⁺, Hg ²⁺) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .

HY-15917S

DL-Dithiothreitol-d10
DL-Dithiothreitol-d₁₀ is the deuterated form of DL-Dithiothreitol. DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .

HY-A0088S

Cefotaxime-d3 sodium
Cefotaxime-d₃ (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-14291S1

Vildagliptin-d7
Vildagliptin-d₇ is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S

Vildagliptin-d3
Vildagliptin-d₃ is the deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-B0215S1

Acetylcysteine-15N

Acetylcysteine- ¹⁵N (N-Acetylcysteine- ¹⁵N) is the ¹⁵N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-14291S2

Vildagliptin-13C5,15N
Vildagliptin- ¹³C₅, ¹⁵N (LAF237- ¹³C₅, ¹⁵N; NVP-LAF 237- ¹³C₅, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-W002004S1

4-Amino-TEMPO-d17

4-Amino-TEMPO-d₁₇ (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d₁₇) is the deuterium labeled 4-Amino-TEMPO (HY-W002004). 4-Amino-TEMPO (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl) is a stable nitroxide radical and N-nucleophile based on TEMPO. 4-Amino-TEMPO has superoxide dismutase-mimetic activity, can protect cells from oxidative damage, and has radioprotective effects. 4-Amino-TEMPO is widely used in fields such as biomedicine, materials science, and industrial production. 4-Amino-TEMPO can be used as a spin label to detect free radicals, an oxidation catalyst in industrial production, and an antioxidant stabilizer for polymers, among others .

HY-15917S1

DL-Dithiothreitol-d10-1
DL-Dithiothreitol-d₁₀-1 is the deuterated form of DL-dithiothreitol. DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-Dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond .

HY-124489S1

2-Hydroxyestradiol-d5
2-Hydroxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[ .

HY-124489S

2-Hydroxyestradiol-13C6
2-Hydroxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-14291S5

Vildagliptin-d6
Vildagliptin-d₆ (LAF237-d₆ ) is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-158186S

Bisoprolol-d6 hemifumarate
Bisoprolol-d₆ fumarate is deuterium labeled Bisoprolol (hemifumarate). Bisoprolol hemifumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol hemifumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .

HY-W002004S

4-Amino-TEMPO-d17,15N

4-Amino-TEMPO-d₁₇, ¹⁵N (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d₁₇, ¹⁵N) is the deuterium labeled 4-Amino-TEMPO-d₁₇ (HY-W002004S1). 4-Amino-TEMPO (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl) is a stable nitroxide radical and N-nucleophile based on TEMPO. 4-Amino-TEMPO has superoxide dismutase-mimetic activity, can protect cells from oxidative damage, and has radioprotective effects. 4-Amino-TEMPO is widely used in fields such as biomedicine, materials science, and industrial production. 4-Amino-TEMPO can be used as a spin label to detect free radicals, an oxidation catalyst in industrial production, and an antioxidant stabilizer for polymers, among others .

HY-W707407

Bisoprolol-d7
Bisoprolol-d₇ is deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .

Cat. No.	Product Name		Classification

HY-W127719

Photobiotin acetate		Azide
Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-103237

L-Adenosine		Nucleoside Analogs Adenosine
L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an K_i value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation .

HY-154644

Soya Lecithin		Emulsifiers Solubilizing Agents
Soya Lecithin is a phospholipid mixture that can be used as a drug delivery vehicle and is a pharmaceutical excipient. Soya Lecithin can form a lipid bilayer structure through self-assembly, and its binding properties are amphiphilic (hydrophilic head and hydrophobic tail), encapsulating hydrophobic drugs. Soya Lecithin forms stable nanoliposomes or microemulsions, improves the solubility and cellular uptake efficiency of poorly soluble drugs (such as Curcumin (HY-N0005)), and exerts activities such as enhancing drug delivery and regulating cell proliferation .

HY-153229

Firefly luciferase mRNA-LNP 1 Publications Verification		mRNA Liposome
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-W129513

Sorbitan monopalmitate		Emulsifiers Surfactants
Sorbitan monopalmitate is a food-grade, non-ionic emulsifier that exhibits oral activity. Sorbitan monopalmitate functions as a crystallization modifier, promoting the aggregation of spherical mango butter crystals, introducing lattice defects, and regulating the crystallization rate of mango butter. Sorbitan monopalmitate serves as a component of precursor vesicle gels, enabling the controlled and sustained release of drugs and facilitating the preparation of stable transdermal delivery formulations .

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