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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
78 Results for "
vasculature
" in MedChemExpress (MCE) Product Catalog:
Products (78)
78 Results for "vasculature" in MCE Product Catalog:
58
58 Publications Verification
Synonyms: XL184; BMS-907351
Target:
Research Areas:
Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis .
9
9 Cited Publications
Cat. No.: HY-D0799
CAS No.: 191671-46-2
Target:
Research Areas:
Sulfo-NHS-LC-Biotin sodium is an amine-reactive ester derivative of biotin and cannot pass the intact blood-retinal barrier. It can be used to assess vascular permeability of the brain and retinal vasculature.
7
Target:
Research Areas:
Infection Cardiovascular Disease Inflammation/Immunology Cancer
Roxithromycin (RU-28965) is an orally active semi-synthethic macrolide antibiotic. Roxithromycin inhibits protein biosynthesis in the elongation step by binding to 50S bacterial ribosome. Roxithromycin has antimicrobial, antiproliferative, anti-inflammatory, tumour vasculature inhibiting and lung injury ameliorating effects .
5
5 Cited Publications
Target:
Research Areas:
SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival .
4
Target:
Research Areas:
Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma .
2
2 Cited Publications
Cat. No.: HY-P99279
CAS No.: 648904-28-3
Synonyms: Anti-Human Phosphatidylserine Recombinant Antibody; PGN-401; CH3G4
Target:
Research Areas:
2
2 Cited Publications
Cat. No.: HY-158082
Synonyms: Tetramethyl rhodamine isothiocyanate glucan, MW 4000
2
Target:
Research Areas:
Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries .
1
1 Cited Publications
Cat. No.: HY-W013215
CAS No.: 28874-58-0
Synonyms: cis-7,10,13,16-Docosatetraenoic acid
Category:
Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Target:
Research Areas:
L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively . L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6 . L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases .
1
1 Cited Publications
Cat. No.: HY-119442
CAS No.: 143816-42-6
Target:
Research Areas:
Quininib is a cysteinyl leukotriene 1 and 2 receptor antagonist with IC50s of 1.2 and 52 μM for CysLT1R and CysLT2R, respectively. Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye. Quininib can be used for the research of ocular neovascular pathologies and may complement current anti-VEGF biological agents .
Cat. No.: HY-P991097
Synonyms: PM-8002; BNT-327
Target:
Research Areas:
Cat. No.: HY-158082A
Synonyms: Tetramethyl rhodamine isothiocyanate glucan, MW 20000
Cat. No.: HY-167851
CAS No.: 1226686-54-9
Target:
Research Areas:
CCX662 is a selective CXCR7 inhibitor with human IC50 values of 9 nM (buffer) and 18 nM (100% human serum), and rat IC50 of 14 nM (100% rat serum). CCX662 blocks CXCL12 binding to CXCR7, inhibits CXCR4-directed trans-endothelial migration of CXCR4 +/CXCR7 + cells. CCX662 can be used for the research of glioblastoma multiforme .
Cat. No.: HY-P10709A
Target:
Research Areas:
Cat. No.: HY-13016R
CAS No.: 849217-68-1
Synonyms: XL184 (Standard); BMS-907351 (Standard)
Research Areas:
Cabozantinib (Standard) is the analytical standard of Cabozantinib. This product is intended for research and analytical applications. Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis .
Cat. No.: HY-158218
Synonyms: Gelatin Methacryloyl, 30% methacrylation, Red Fluorescent
Application: cell culture, biological 3D printing, tissue engineering, etc.
Cat. No.: HY-168943
Cat. No.: HY-161248
Target:
Research Areas:
E7130 is a microtubule inhibitor, which ameliorates the tumor microenvironment through suppression of cancer-associated fibroblasts (CAF) and promotion of tumor vasculature remodeling .
Cat. No.: HY-158217
Synonyms: Gelatin Methacryloyl, 30% methacrylation, Green Fluorescent
Application: cell culture, biological 3D printing, tissue engineering, etc.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
