1451272-71-1
1451272-71-1
Chemical Structure
SBI-425
- CAS No.: 1451272-71-1
- Formula:C13H12ClN3O4S
- Molecular Weight:341.77
IUPAC Name: 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide
InChIKey: SBAITEDLNTYIOE-UHFFFAOYSA-N
SMILES: O=C(C1=CC(NS(=O)(C2=CC(Cl)=CC=C2OC)=O)=CN=C1)N
Biological Activity: SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2].
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SBI-425 | 98.88% | SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.63
HY-155170MTDH-SND1 blocker 1 -
Similarity Score 0.63
HY-14210TNAP-IN-1 -
Similarity Score 0.59
HY-15721FH535 -
Similarity Score 0.59
HY-146165Metallo-β-lactamase-IN-8 -
Similarity Score 0.58
HY-W011082NLRP3-IN-2 -
Similarity Score 0.58
HY-152140hCAII-IN-8 -
Similarity Score 0.58
HY-101998RCTP inhibitor (Standard) -
Similarity Score 0.58
HY-120697MSAB -
Similarity Score 0.58
HY-16586PFI-1 -
Explore the MedChemAI to find more analogs
References
- [1]. Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. [Content Brief]
- [2]. Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36. [Content Brief]
