2. GPCR/G Protein
  3. Leukotriene Receptor
  4. Quininib

Quininib is a cysteinyl leukotriene 1 and 2 receptor antagonist with IC50s of 1.2 and 52 μM for CysLT1R and CysLT2R, respectively. Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye. Quininib can be used for the research of ocular neovascular pathologies and may complement current anti-VEGF biological agents.

For research use only. We do not sell to patients.

Quininib Chemical Structure

Quininib Chemical Structure

CAS No. : 143816-42-6

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Quininib Related Antibodies

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

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Description

Quininib is a cysteinyl leukotriene 1 and 2 receptor antagonist with IC50s of 1.2 and 52 μM for CysLT1R and CysLT2R, respectively. Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye. Quininib can be used for the research of ocular neovascular pathologies and may complement current anti-VEGF biological agents[1].

IC50 & Target

CysLT1

1.2 μM (IC50)

CysLT2

52 μM (IC50)

Molecular Weight

247.29

Formula

C17H13NO
CAS No.
SMILES

OC1=CC=CC=C1/C=C/C2=NC3=CC=CC=C3C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Quininib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quininib143816-42-6Leukotriene ReceptorangiogenesiseyeG protein-coupled receptorGPCRleukotrieneblindnesshyaloid vasculature developmentocular angiogenesiscysteinyl leukotriene receptorCysLT1RCysLT2RInhibitorinhibitorinhibit

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