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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
xeroderma pigmentosum
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "xeroderma pigmentosum" in MCE Product Catalog:
1
Target:
Clemizole hydrochloride is an orally active, blood-brain barrier permeable TRPC5 inhibitor, with an IC50 value of 1.05-1.34 μM against mouse TRPC5. Clemizole hydrochloride blocks TRPC1:TRPC5, TRPC3, TRPC4, TRPC6, TRPC7, hERG, hKCNQ1/hKCNE1 and hKv1.5 channels, and activates TRPA1; it modulates 5HT-2B and HTR2A receptors; it inhibits HCV RNA replication, CrtN enzymatic activity, oxidative stress, neuroinflammation, cell apoptosis and bacterial virulence; it maintains blood-brain barrier (BBB) integrity; it enhances DNA repair capacity; it improves cell viability; and it alters cardiac electrophysiological properties. Clemizole hydrochloride can be used in the research of Dravet syndrome, hepatitis C virus infection, Staphylococcus aureus skin infection, Cisplatin (HY-17394)-induced nephrotoxicity, STXBP1-related diseases, traumatic brain injury and xeroderma pigmentosum type C .
1
Target:
Clemizole is an orally active, blood-brain barrier permeable TRPC5 inhibitor, with an IC50 value of 1.05-1.34 μM against mouse TRPC5. Clemizole blocks TRPC1:TRPC5, TRPC3, TRPC4, TRPC6, TRPC7, hERG, hKCNQ1/hKCNE1 and hKv1.5 channels, and activates TRPA1; it modulates 5HT-2B and HTR2A receptors; it inhibits HCV RNA replication, CrtN enzymatic activity, oxidative stress, neuroinflammation, cell apoptosis and bacterial virulence; it maintains blood-brain barrier (BBB) integrity; it enhances DNA repair capacity; it improves cell viability; and it alters cardiac electrophysiological properties. Clemizole can be used in the research of Dravet syndrome, hepatitis C virus infection, Staphylococcus aureus skin infection, Cisplatin (HY-17394)-induced nephrotoxicity, STXBP1-related diseases, traumatic brain injury and xeroderma pigmentosum type C .
Target:
Research Areas:
TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC50s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC50s of 21, 39, and 28 in ELISA Analysis .
Cat. No.: HY-153792
CAS No.: 824983-90-6
FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents .
Cat. No.: HY-153791
CAS No.: 824983-84-8
FEN1-IN-6 (compound 9) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 23 nM .
Cat. No.: HY-30234S
CAS No.: 1251554-64-9
Cat. No.: HY-30234B
CAS No.: 17162-20-8
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Endocrinology
Clemizole sulfate is an orally active, blood-brain barrier permeable TRPC5 inhibitor, with an IC50 value of 1.05-1.34 μM against mouse TRPC5. Clemizole sulfate blocks TRPC1:TRPC5, TRPC3, TRPC4, TRPC6, TRPC7, hERG, hKCNQ1/hKCNE1 and hKv1.5 channels, and activates TRPA1; it modulates 5HT-2B and HTR2A receptors; it inhibits HCV RNA replication, CrtN enzymatic activity, oxidative stress, neuroinflammation, cell apoptosis and bacterial virulence; it maintains blood-brain barrier (BBB) integrity; it enhances DNA repair capacity; it improves cell viability; and it alters cardiac electrophysiological properties. Clemizole sulfate can be used in the research of Dravet syndrome, hepatitis C virus infection, Staphylococcus aureus skin infection, Cisplatin (HY-17394)-induced nephrotoxicity, STXBP1-related diseases, traumatic brain injury and xeroderma pigmentosum type C .
Cat. No.: HY-P702825
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein Cereblon; Cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; xeroderma pigmentosum Group E-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702850
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein Cereblon; Cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; xeroderma pigmentosum Group E-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702851
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein Cereblon; Cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; xeroderma pigmentosum Group E-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703563
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; xeroderma pigmentosum Group E-Complementing Protein; Damage-Specific DNA Binding Protein 1 (127kD); Damage-Specific DNA-Binding Protein 1; Damage-Specific DNA
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706007
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein Cereblon; Cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; xeroderma pigmentosum Group E-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702817
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein Cereblon; Cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; xeroderma pigmentosum Group E-
Species:
Human
Source:
HEK293
Cat. No.: HY-P702826
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein Cereblon; Cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; xeroderma pigmentosum Group E-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P85582
Synonyms: Damage specific DNA binding protein 1; Damage-specific DNA-binding protein 1; DDB 1; DDB p127 subunit; Ddb1; DDB1_HUMAN; DDBa; DNA damage binding protein 1; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1; UV damaged DNA binding factor; UV damaged DNA binding protein 1; UV DDB 1; UV DDB1; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; UV-DDB 1; UV-DDB1; X associated protein 1; XAP 1; XAP-1; XAP1; xeroderma pigmentosum group E complementing protein; xeroderma pigmentosum group E-complementing protein; XPCE; XPE; XPE BF; XPE binding factor; XPE-BF; XPE-binding factor.
Cat. No.: HY-P703562
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: WDTC1; WD And Tetratricopeptide Repeats Protein 1; WD And Tetratricopeptide Repeats 1; DDB1 And CUL4 Associated Factor 9; KIAA1037; Adipose Homolog (Drosophila); DCAF9; Adipose Homolog; ADP; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; xeroderma pigmentosum Group E-Complementing Protein; Damage-Specific DNA Binding Protein 1 (127kD); Damage-Specific DNA-Binding Protein 1; Damage-Specific DNA Binding Protein 1, 127kDa; UV-Damaged DNA-Binding Protein 1; UV-DDB1; UV-Damaged DNA-Binding Factor; WHIKERS; DNA Damage-Binding Protein A; DDBA; HBV X-Associated Protein 1; XPCE; XPE-Binding Factor; XPCe; DDB P127 Subunit; DDBa; UV-DDB 1; XPE
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703363
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DCAF10; WD Repeat-Containing Protein 32; Prev. WDR32; MGC10765; DDB1- And CUL4-Associated Factor 10; FLJ23201; DDB1 And CUL4 Associated Factor 10; WD Repeat Domain 32; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; xeroderma pigmentosum Group E-Complementing Protein; Damage-Specific DNA Binding Protein 1 (127kD); Damage-Specific DNA-Binding Protein 1; Damage-Specific DNA Binding Protein 1, 127kDa; UV-Damaged DNA-Binding Protein 1; UV-DDB1; UV-Damaged DNA-Binding Factor; WHIKERS; DNA Damage-Binding Protein A; DDBA; HBV X-Associated Protein 1; XPCE; XPE-Binding Factor; XPCe; DDB P127 Subunit; DDBa; UV-DDB 1; XPE
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
