824983-84-8
824983-84-8
Chemical Structure
FEN1-IN-6
- CAS 番号: 824983-84-8
- Formula:C12H8N2O5S2
- Molecular Weight:324.33
InChIKey: JBDRLOXEKRVFOS-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C(N1O)=O)SC=C2S(=O)(C3=CC=CC=C3)=O
Biological Activity: FEN1-IN-6 (compound 9) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 23 nM[1].
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FEN1-IN-6 | FEN1-IN-6 (compound 9) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 23 nM. | |||||||||||||||||||||
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References
Keywords
