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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
yeast DNA topoisomerase II
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "yeast DNA topoisomerase II" in MCE Product Catalog:
19
19 Publications Verification
Cat. No.: HY-17381
CAS No.: 57852-57-0
Synonyms: 4-Demethoxydaunorubicin hydrochloride
Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.
19
19 Publications Verification
Cat. No.: HY-17381A
CAS No.: 58957-92-9
Synonyms: 4-Demethoxydaunorubicin
Idarubicin is an orally active and potent anthracycline antileukemic agent. Idarubicin inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin shows induction of DNA damage. Idarubicin inhibits DNA synthesis and of c-myc expression. Idarubicin inhibits the growth of bacteria and yeasts .
2
2 Cited Publications
Research Areas:
Infection Cardiovascular Disease Inflammation/Immunology Cancer
ICRF-193 is a DNA Topoisomerase II inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia .
Cat. No.: HY-17381R
CAS No.: 57852-57-0
Synonyms: 4-Demethoxydaunorubicin hydrochloride (Standard)
Idarubicin (hydrochloride) (Standard) is the analytical standard of Idarubicin (hydrochloride). This product is intended for research and analytical applications. Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.
Cat. No.: HY-17525
CAS No.: 163269-30-5
Research Areas:
Bethoxazin is a yeast DNA topoisomerase II inhibitor with an IC50 of 5.3 μM, and also a broad-spectrum industrial microbicide and covalent adduct-forming agent. Bethoxazin inhibits the catalytic activity of yeast DNA topoisomerase II by reacting with the key free cysteine thiol group on the enzyme. Bethoxazin forms covalent adducts with molecules containing free thiol groups. Bethoxazin inhibits the growth of yeast cells. Bethoxazin can be used in studies related to the growth of fungi, molds and algae .
Cat. No.: HY-118590A
CAS No.: 21416-68-2
Research Areas:
Infection Cardiovascular Disease Inflammation/Immunology Cancer
ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193 (HY-118590). ICRF-193 is a DNA Topoisomerase II inhibitor. ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia .
Cat. No.: HY-E70902
Target:
Research Areas:
Topoisomerase II, Yeast (EC 5.99.1.3) is a nuclear enzyme that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I, which makes single-stranded cuts in DNA, and type II enzymes, which cut and pass double-stranded DNA.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
