Telmisartan acyl-β-D-glucuronide
Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions.
For research use only. We do not sell to patients.
- CAS No.: 250780-40-6
- Formula: C39H38N4O8
- Molecular Weight:690.74
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Telmisartan acyl-β-D-glucuronide (0.2 mM; 4 h incubation in phosphate buffer) forms diagnostic [M-H+BF3-2HF]- and [M-H+2BF3-3HF]- ions with BF3, and CAD of the secondary diagnostic ion produces a fragment via an 88 Da mass loss, while unmigrated Telmisartan acyl-β-D-glucuronide does not form these diagnostic ions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 250780-40-6
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Appearance Solid
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Molecular Weight 690.74
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Formula C39H38N4O8
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Color White to off-white
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SMILES
CCCC(N(C1=CC(C2=NC3=CC=CC=C3N2C)=C4)CC5=CC=C(C6=C(C=CC=C6)C(O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)C(O)=O)=O)C=C5)=NC1=C4C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (72.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Niyonsaba E, et al. Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion-Molecule Reactions Followed by Collision-Activated Dissociation. Anal Chem. 2019;91(17):11388-11396. [Content Brief]
[2]. Stangier J, et al. Absorption, metabolism, and excretion of intravenously and orally administered [14C]telmisartan in healthy volunteers. J Clin Pharmacol. 2000;40(12 Pt 1):1312-1322. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4477 mL | 7.2386 mL | 14.4772 mL | 36.1931 mL |
| 5 mM | 0.2895 mL | 1.4477 mL | 2.8954 mL | 7.2386 mL | |
| 10 mM | 0.1448 mL | 0.7239 mL | 1.4477 mL | 3.6193 mL | |
| 15 mM | 0.0965 mL | 0.4826 mL | 0.9651 mL | 2.4129 mL | |
| 20 mM | 0.0724 mL | 0.3619 mL | 0.7239 mL | 1.8097 mL | |
| 25 mM | 0.0579 mL | 0.2895 mL | 0.5791 mL | 1.4477 mL | |
| 30 mM | 0.0483 mL | 0.2413 mL | 0.4826 mL | 1.2064 mL | |
| 40 mM | 0.0362 mL | 0.1810 mL | 0.3619 mL | 0.9048 mL | |
| 50 mM | 0.0290 mL | 0.1448 mL | 0.2895 mL | 0.7239 mL | |
| 60 mM | 0.0241 mL | 0.1206 mL | 0.2413 mL | 0.6032 mL |
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