Telmisartan acyl-β-D-glucuronide

Name: Telmisartan acyl-β-D-glucuronide
Brand: MedChemExpress
SKU: HY-137959
Rating: 4.5 (1 reviews)

Cat. No.: HY-137959: Data Sheet
COA

SDS
Handling Instructions
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Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions.

For research use only. We do not sell to patients.

Telmisartan acyl-β-D-glucuronide Chemical Structure

CAS No. : 250780-40-6

Size	Stock	Quantity
1 mg	Get quote 4 - 5 weeks 5 - 6 weeks 6 - 7 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
2.5 mg	Get quote 4 - 5 weeks 5 - 6 weeks 6 - 7 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 4 - 5 weeks 5 - 6 weeks 6 - 7 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Telmisartan acyl-β-D-glucuronide (0.2 mM; 4 h incubation in phosphate buffer) forms diagnostic [M-H+BF₃-2HF]^- and [M-H+2BF₃-3HF]^- ions with BF₃, and CAD of the secondary diagnostic ion produces a fragment via an 88 Da mass loss, while unmigrated Telmisartan acyl-β-D-glucuronide does not form these diagnostic ions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

690.74

Formula

C₃₉H₃₈N₄O₈

CAS No.

250780-40-6

Appearance

Solid

Color

White to off-white

SMILES

CCCC(N(C1=CC(C2=NC3=CC=CC=C3N2C)=C4)CC5=CC=C(C6=C(C=CC=C6)C(O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)C(O)=O)=O)C=C5)=NC1=C4C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (72.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4477 mL	7.2386 mL	14.4772 mL
5 mM	0.2895 mL	1.4477 mL	2.8954 mL
10 mM	0.1448 mL	0.7239 mL	1.4477 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 94.68%

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Data Sheet (277 KB) SDS (252 KB)

COA (257 KB)

Handling Instructions (2659 KB)

References

[1]. Niyonsaba E, et al. Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion-Molecule Reactions Followed by Collision-Activated Dissociation. Anal Chem. 2019;91(17):11388-11396.

[2]. Stangier J, et al. Absorption, metabolism, and excretion of intravenously and orally administered [14C]telmisartan in healthy volunteers. J Clin Pharmacol. 2000;40(12 Pt 1):1312-1322.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4477 mL	7.2386 mL	14.4772 mL	36.1931 mL
	5 mM	0.2895 mL	1.4477 mL	2.8954 mL	7.2386 mL
	10 mM	0.1448 mL	0.7239 mL	1.4477 mL	3.6193 mL
	15 mM	0.0965 mL	0.4826 mL	0.9651 mL	2.4129 mL
	20 mM	0.0724 mL	0.3619 mL	0.7239 mL	1.8097 mL
	25 mM	0.0579 mL	0.2895 mL	0.5791 mL	1.4477 mL
	30 mM	0.0483 mL	0.2413 mL	0.4826 mL	1.2064 mL
	40 mM	0.0362 mL	0.1810 mL	0.3619 mL	0.9048 mL
	50 mM	0.0290 mL	0.1448 mL	0.2895 mL	0.7239 mL
	60 mM	0.0241 mL	0.1206 mL	0.2413 mL	0.6032 mL