2. Neuronal Signaling
  3. Monoamine Oxidase
  4. Tranylcypromine

Tranylcypromine (SKF 385) is a potent monoamine oxidase (MAO) inhibitor.

For research use only. We do not sell to patients.

CAS No. : 155-09-9

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Other In-stock Forms of Tranylcypromine:

Tranylcypromine Related Antibodies

Top Publications Citing Use of Products

    Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073.  [Abstract]

    Schematic diagram of Triflupromazine and Tranylcypromine hydrochloride alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination. LDHA interacts with AMBRA1 via non-metabolic enzyme functions, promoting AMBRA1 ubiquitination and degradation, which leads to cisplatin resistance by regulating the cell cycle and apoptosis.

    Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073.  [Abstract]

    Tranylcypromine hydrochloride (0-100 μM) significantly inhibited LDHA expression and increased AMBRA1 protein levels in resistant cell line H1838.

    Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073.  [Abstract]

    CCK8 assay evaluating the survival of H1838 treated with serial concentrations of cisplatin in combination with Tranylcypromine hydrochloride (0-100 μM, 48 h).

    Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073.  [Abstract]

    Apoptosis analysis in H1838 cells treated with cisplatin accompanied by TRI (5 μM) and Tranylcypromine hydrochloride (50 μM) respectively for 48 h.

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    Description

    Tranylcypromine (SKF 385) is a potent monoamine oxidase (MAO) inhibitor[1].

    In Vivo

    rel-Tranylcypromine (SKF 385) (0.1 to 3.0 mg/kg; intravenous injection; mongrel dogs, weighing 5-10 kg) elevates the blood pressure. The extent and duration of the rise of blood pressure by the drug depended on the dose administered. When the administration of rel-Tranylcypromine is repeated again and again, the depressor response of the animal to rel-Tranylcypromine is usually obtained[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    133.19

    Formula

    C9H11N
    CAS No.
    SMILES

    N[C@H]1[C@H](C2=CC=CC=C2)C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Tranylcypromine Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tranylcypromine155-09-9SKF 385SKF385SKF-385Monoamine OxidaseMAOblood pressuredepressorsympathomimetic effectsInhibitorinhibitorinhibit

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