Tranylcypromine (Synonyms: SKF 385)

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Tranylcypromine (SKF 385) is a potent monoamine oxidase (MAO) inhibitor.

For research use only. We do not sell to patients.

CAS No. : 155-09-9

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Other In-stock Forms of Tranylcypromine:

Tranylcypromine hydrochloride Tranylcypromine hemisulfate

Other Forms of Tranylcypromine:

Tranylcypromine hydrochloride In-stock
Tranylcypromine hemisulfate In-stock
Tranylcypromine-d₅ hydrochloride Get quote

9 Publications Citing Use of MCE Tranylcypromine

Others

Cell Proliferation/Viability Assay

Flow Cytometry

: Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073. [Abstract]; Schematic diagram of Triflupromazine and Tranylcypromine hydrochloride alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination. LDHA interacts with AMBRA1 via non-metabolic enzyme functions, promoting AMBRA1 ubiquitination and degradation, which leads to cisplatin resistance by regulating the cell cycle and apoptosis.

: Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073. [Abstract]; Tranylcypromine hydrochloride (0-100 μM) significantly inhibited LDHA expression and increased AMBRA1 protein levels in resistant cell line H1838.

: Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073. [Abstract]; CCK8 assay evaluating the survival of H1838 treated with serial concentrations of cisplatin in combination with Tranylcypromine hydrochloride (0-100 μM, 48 h).

: Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073. [Abstract]; Apoptosis analysis in H1838 cells treated with cisplatin accompanied by TRI (5 μM) and Tranylcypromine hydrochloride (50 μM) respectively for 48 h.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Tranylcypromine (SKF 385) is a potent monoamine oxidase (MAO) inhibitor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	1108 μM Compound: PCPA	Growth inhibition of human A549 cells after 72 hrs by Alamarblue assay Growth inhibition of human A549 cells after 72 hrs by Alamarblue assay	[PMID: 29331452]
B16-F10	IC₅₀	>64 μM Compound: TCP	Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31881456]
BGC-823	IC₅₀	>50 μM Compound: TCP	Antiproliferative activity against human BGC-823 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human BGC-823 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
CHO-K1	EC₅₀	1510 nM Compound: 46	Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay	[PMID: 18602830]
ECa-109 cell line	IC₅₀	>64 μM Compound: TCP	Cytotoxicity against human EC-109 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human EC-109 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31881456]
GES1	IC₅₀	>50 μM Compound: TCP	Cytotoxicity against human GES1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human GES1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
HEK293	GI₅₀	>500 μM Compound: PCPA	Growth inhibition of human HEK293 cells after 48 hrs by MTT assay Growth inhibition of human HEK293 cells after 48 hrs by MTT assay	[PMID: 21227703]
HeLa	GI₅₀	>500 μM Compound: PCPA	Growth inhibition of human HeLa cells after 48 hrs by MTT assay Growth inhibition of human HeLa cells after 48 hrs by MTT assay	[PMID: 21227703]
LNCaP	IC₅₀	>100000 μM Compound: (+)-tranylcypromine	Growth inhibition of human LNCAP cells after 6 days Growth inhibition of human LNCAP cells after 6 days	[PMID: 21382717]
MCF7	IC₅₀	>100 μM Compound: 1; PCPA	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 32283297]
MCF7	IC₅₀	>50 μM Compound: TCP	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
MCF7	IC₅₀	2518.9 μM Compound: Tranylcypromine	Cytotoxic activity against human MCF7 cells after 24 hrs by MTT assay Cytotoxic activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 29496367]
MGC-803	IC₅₀	>50 μM Compound: TCP	Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
MGC-803	IC₅₀	>64 μM Compound: TCP	Cytotoxicity against human MGC-803 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MGC-803 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31881456]
MV4-11	IC₅₀	>100 μM Compound: 1; TCP	Antiproliferative activity against human MV4-11 cells after 168 hrs by MTS assay Antiproliferative activity against human MV4-11 cells after 168 hrs by MTS assay	[PMID: 30713023]
NCI-H1975	IC₅₀	>50 μM Compound: TCP	Antiproliferative activity against human NCI-H1975 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
NCI-H460	IC₅₀	>50 μM Compound: TCP	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
PC-3	IC₅₀	>64 μM Compound: TCP	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31881456]
SH-SY5Y	GI₅₀	500 μM Compound: PCPA	Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 21227703]

In Vivo

rel-Tranylcypromine (SKF 385) (0.1 to 3.0 mg/kg; intravenous injection; mongrel dogs, weighing 5-10 kg) elevates the blood pressure. The extent and duration of the rise of blood pressure by the drug depended on the dose administered. When the administration of rel-Tranylcypromine is repeated again and again, the depressor response of the animal to rel-Tranylcypromine is usually obtained^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

133.19

Formula

C₉H₁₁N

CAS No.

155-09-9

SMILES

N[C@H]1[C@H](C2=CC=CC=C2)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. TODA N, et al. The sympathomimetic effects of SKF-385 on blood pressure in dog. Jpn J Pharmacol. 1962;12:166-179. [Content Brief]

Tranylcypromine Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tranylcypromine155-09-9SKF 385SKF385SKF-385Monoamine OxidaseMAOblood pressuredepressorsympathomimetic effectsInhibitorinhibitorinhibit

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