Cat. No.: HY-17447

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Tranylcypromine

(Synonyms: SKF 385)

9 Cited Publications

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Based on 9 publication(s) in Google Scholar

Tranylcypromine (SKF 385) is a potent monoamine oxidase (MAO) inhibitor.

For research use only. We do not sell to patients.

CAS No.: 155-09-9
Formula: C₉H₁₁N
Molecular Weight:133.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Tranylcypromine Chemical Structure

CAS No.: 155-09-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
- Clinical Trial
Chemical Information
Publications (9)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Tranylcypromine (SKF 385) is a potent monoamine oxidase (MAO) inhibitor^[1].

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	1108 μM Compound: PCPA	Growth inhibition of human A549 cells after 72 hrs by Alamarblue assay Growth inhibition of human A549 cells after 72 hrs by Alamarblue assay	[PMID: 29331452]
B16-F10	IC₅₀	>64 μM Compound: TCP	Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31881456]
BGC-823	IC₅₀	>50 μM Compound: TCP	Antiproliferative activity against human BGC-823 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human BGC-823 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
CHO-K1	EC₅₀	1510 nM Compound: 46	Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay	[PMID: 18602830]
ECa-109 cell line	IC₅₀	>64 μM Compound: TCP	Cytotoxicity against human EC-109 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human EC-109 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31881456]
GES1	IC₅₀	>50 μM Compound: TCP	Cytotoxicity against human GES1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human GES1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
HEK293	GI₅₀	>500 μM Compound: PCPA	Growth inhibition of human HEK293 cells after 48 hrs by MTT assay Growth inhibition of human HEK293 cells after 48 hrs by MTT assay	[PMID: 21227703]
HeLa	GI₅₀	>500 μM Compound: PCPA	Growth inhibition of human HeLa cells after 48 hrs by MTT assay Growth inhibition of human HeLa cells after 48 hrs by MTT assay	[PMID: 21227703]
LNCaP	IC₅₀	>100000 μM Compound: (+)-tranylcypromine	Growth inhibition of human LNCAP cells after 6 days Growth inhibition of human LNCAP cells after 6 days	[PMID: 21382717]
MCF7	IC₅₀	>100 μM Compound: 1; PCPA	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 32283297]
MCF7	IC₅₀	>50 μM Compound: TCP	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
MCF7	IC₅₀	2518.9 μM Compound: Tranylcypromine	Cytotoxic activity against human MCF7 cells after 24 hrs by MTT assay Cytotoxic activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 29496367]
MGC-803	IC₅₀	>50 μM Compound: TCP	Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
MGC-803	IC₅₀	>64 μM Compound: TCP	Cytotoxicity against human MGC-803 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MGC-803 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31881456]
MV4-11	IC₅₀	>100 μM Compound: 1; TCP	Antiproliferative activity against human MV4-11 cells after 168 hrs by MTS assay Antiproliferative activity against human MV4-11 cells after 168 hrs by MTS assay	[PMID: 30713023]
NCI-H1975	IC₅₀	>50 μM Compound: TCP	Antiproliferative activity against human NCI-H1975 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
NCI-H460	IC₅₀	>50 μM Compound: TCP	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34416665]
PC-3	IC₅₀	>64 μM Compound: TCP	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31881456]
SH-SY5Y	GI₅₀	500 μM Compound: PCPA	Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 21227703]

In Vivo

rel-Tranylcypromine (SKF 385) (0.1 to 3.0 mg/kg; intravenous injection; mongrel dogs, weighing 5-10 kg) elevates the blood pressure. The extent and duration of the rise of blood pressure by the drug depended on the dose administered. When the administration of rel-Tranylcypromine is repeated again and again, the depressor response of the animal to rel-Tranylcypromine is usually obtained^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 155-09-9
Molecular Weight 133.19
Formula C₉H₁₁N
SMILES

N[C@H]1[C@H](C2=CC=CC=C2)C1
Synonyms

SKF 385
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (9)

All OthersWBCell Proliferation/Viability AssayFlow Cytometry

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Biomaterials

Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells. [Abstract]

2018 Dec 6;193:30-46. PMID: 30554025
Stem Cell Res Ther

Characterisation of extraembryonic endoderm-like cells from mouse embryonic fibroblasts induced using chemicals alone. [Abstract]

2020 Apr 16;11(1):157. PMID: 32299508
Biochem Pharmacol

Triflupromazine and tranylcypromine alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination. [Abstract]

2025 Jun 23:117073. PMID: 40562117

Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073. [Abstract]

Schematic diagram of Triflupromazine and Tranylcypromine hydrochloride alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination. LDHA interacts with AMBRA1 via non-metabolic enzyme functions, promoting AMBRA1 ubiquitination and degradation, which leads to cisplatin resistance by regulating the cell cycle and apoptosis.

Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073. [Abstract]

Tranylcypromine hydrochloride (0-100 μM) significantly inhibited LDHA expression and increased AMBRA1 protein levels in resistant cell line H1838.

Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073. [Abstract]

CCK8 assay evaluating the survival of H1838 treated with serial concentrations of cisplatin in combination with Tranylcypromine hydrochloride (0-100 μM, 48 h).

Tranylcypromine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jun 23:117073. [Abstract]

Apoptosis analysis in H1838 cells treated with cisplatin accompanied by TRI (5 μM) and Tranylcypromine hydrochloride (50 μM) respectively for 48 h.
Int Immunopharmacol

Tangeretin protects the kidney from ischemia-reperfusion injury by inhibiting inflammatory response through downregulation of MAOA. [Abstract]

2025 Jul 18:163:115242. PMID: 40682983
Int Immunopharmacol

Curcumin combined with arsenic trioxide enhances autophagy and immune surveillance to inhibit immune escape in acute myeloid leukemia. [Abstract]

2025 May 28:159:114966. PMID: 40440957
Clin Exp Med

Corin: a dual inhibitor for KDM1A/HDAC1, suppresses hepatocellular carcinoma by triggering cuproptosis. [Abstract]

2025 Nov 25;26(1):33. PMID: 41286164
Biol Reprod

Prostaglandin I2 mediates weak vasodilatation in human placental microvessels. [Abstract]

2020 Dec 1;103(6):1229-1237. PMID: 32902654
Biochem Biophys Res Commun

Suppression of LSD1 enhances the cytotoxic and apoptotic effects of regorafenib in hepatocellular carcinoma cells. [Abstract]

2019 May 14;512(4):852-858. PMID: 30929918
Patent

US20180263995A1.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. TODA N, et al. The sympathomimetic effects of SKF-385 on blood pressure in dog. Jpn J Pharmacol. 1962;12:166-179. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Tranylcypromine

9 Cited Publications

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Tranylcypromine

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Tranylcypromine

All Monoamine Oxidase Isoforms

Biological Activity

Chemical Information

Publications (9)

Purity & Documentation

References

Calculators

Help & FAQs

Tranylcypromine

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Tranylcypromine

All Monoamine Oxidase Isoforms

Biological Activity

Chemical Information

Publications (9)

Purity & Documentation

References

Calculators

Help & FAQs

Tranylcypromine Related Classifications

HY-17447 Related Classifications