2. PROTAC
  3. LYTACs
  4. TriGalNAc CBz

TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies.

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TriGalNAc CBz

TriGalNAc CBz Chemische Struktur

CAS. Nr. : 186613-57-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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TriGalNAc CBz Related Antibodies

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Beschreibung

TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies[1].
In Vitro

TriGalNAc CBz acts as the linker and can be used for synthesis of GalNAc-LYTACs. TriGalNAc CBz binds to the ASGPR receptor specifically expressed in hepatocytes, transports the target protein and the receptor complex to the endosome. Tri-GalNAc would be released in the acidic environment of the endosome, and the target protein is transported to the lysosome, where it is degraded[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TriGalNAc CBz Related Antibodies
Molekulargewicht

633.64

Formel

C34H35NO11
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)O[C@H]2[C@H]([C@H](O[C@H]([C@@H]2NC(C)=O)OCCCCC(O)=O)COC(C3=CC=CC=C3)=O)OC(C4=CC=CC=C4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 100 mg/mL (157.82 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5782 mL 7.8909 mL 15.7818 mL
5 mM 0.3156 mL 1.5782 mL 3.1564 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 98.73%

SDS (393 KB)

COA (254 KB) HNMR (322 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5782 mL 7.8909 mL 15.7818 mL 39.4546 mL
5 mM 0.3156 mL 1.5782 mL 3.1564 mL 7.8909 mL
10 mM 0.1578 mL 0.7891 mL 1.5782 mL 3.9455 mL
15 mM 0.1052 mL 0.5261 mL 1.0521 mL 2.6303 mL
20 mM 0.0789 mL 0.3945 mL 0.7891 mL 1.9727 mL
25 mM 0.0631 mL 0.3156 mL 0.6313 mL 1.5782 mL
30 mM 0.0526 mL 0.2630 mL 0.5261 mL 1.3152 mL
40 mM 0.0395 mL 0.1973 mL 0.3945 mL 0.9864 mL
50 mM 0.0316 mL 0.1578 mL 0.3156 mL 0.7891 mL
60 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6576 mL
80 mM 0.0197 mL 0.0986 mL 0.1973 mL 0.4932 mL
100 mM 0.0158 mL 0.0789 mL 0.1578 mL 0.3945 mL
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TriGalNAc CBz Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TriGalNAc CBz186613-57-0LYTACsLysosome-targeting chimerasGalNAc derivativeasialoglycoprotein receptorASGPRmRNA drug deliverylysosomal targeted chimerismLYTACInhibitorinhibitorinhibit

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