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Cat. No.: HY-151996

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Tubulin inhibitor 31

Tubulin inhibitor 31 is a potent tubulin inhibitor with an IC₅₀ value of 4 μM. Tubulin inhibitor 31 shows anti-proliferative activity. Tubulin inhibitor 31 inhibits the HUVEC migration.

For research use only. We do not sell to patients.

CAS No.: 3033553-03-3
Formula: C₂₂H₁₉NO₂
Molecular Weight:329.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Tubulin inhibitor 31 Chemical Structure

CAS No.: 3033553-03-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Tubulin inhibitor 31 is a potent tubulin inhibitor with an IC₅₀ value of 4 μM. Tubulin inhibitor 31 shows anti-proliferative activity. Tubulin inhibitor 31 inhibits the HUVEC migration^[1].

IC₅₀ & Target

IC₅₀: 4 µM (Tubulin)^[1]

In Vitro

Tubulin inhibitor 31 (compound 4J) (0-100 μM; 72 h) shows anti-proliferative activity with IC₅₀s of 0.126, 0.39 μM for HUVEC, HIG-82 cells^[1].
Tubulin inhibitor 31 (0.012, 0.063 μM; 10 h) significantly inhibits the HUVEC migration in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HUVEC, HIG-82 cells
Concentration:

0-100 µM
Incubation Time:

72 h
Result:

Showed anti-proliferative activity with IC₅₀s of 0.126, 0.39 µM for HUVEC, HIG-82 cells.

Chemical Information

CAS No. 3033553-03-3
Molecular Weight 329.39
Formula C₂₂H₁₉NO₂
SMILES

COC1=CC=C(C=C1)CN2C=C(C3=C2C=CC=C3)C4=CC=C(C=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Prudhomme V, et al. Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA). Eur J Med Chem. 2022 Dec 15;244:114809. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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