Tubulin polymerization-IN-58
Tubulin polymerization-IN-58 (Compound K18) is a tubulin polymerization inhibitor with an IC50 of 0.446 μM. Tubulin polymerization-IN-58 also induces the degradation of oncogenic protein YAP via the UPS pathway, thus can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3027015-30-8
- Formula: C29H29N5O6S2
- Molecular Weight:607.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All YAP Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.062 μM
Compound: K18
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method
|
[PMID: 38181651] |
| KYSE-30 | IC50 |
0.042 μM
Compound: K18
|
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method
|
[PMID: 38181651] |
Chemical Information
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CAS No. 3027015-30-8
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Molecular Weight 607.70
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Formula C29H29N5O6S2
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SMILES
OC1=C(OC)C=CC(CN(C2=CC(OC)=C(OC)C(OC)=C2)C(CN3C=C(CSC4=NC5=C(C=CC=C5)S4)N=N3)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)