Tubulin polymerization-IN-90
Tubulin polymerization-IN-90 is a tubulin polymerization inhibitor. Tubulin polymerization-IN-90 disrupts tubulin polymerization by binding to the nocodazole-binding site on β-tubulin. Tubulin polymerization-IN-90 induces the release of extracellular vesicles marked by the tetraspanin CD63. Tubulin polymerization-IN-90 induces the release of IL-8 from cells. Tubulin polymerization-IN-90 reduces the viability of cancer cells. Tubulin polymerization-IN-90 can be used in the research of cancers such as acute T-lymphoblastic leukemia.
For research use only. We do not sell to patients.
- CAS No.: 3006800-41-2
- Formula: C21H14N4S
- Molecular Weight:354.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tubulin polymerization-IN-90 (Compound 39) (10 μM; 48 h) significantly enhances the activity of the CD63 extracellular vesicle release reporter gene in CD63 Tluc-CD9 EmGFP THP-1 cells[1].
Tubulin polymerization-IN-90 (1-10 μM) inhibits tubulin polymerization in a dose-dependent manner[1].
Tubulin polymerization-IN-90 (0.001-0.1 μM; 20 h) inhibits the viability of wild-type CEM T cells with an IC50 of 0.09 μM; it also inhibits the viability of CEM-178 TUBB mutant cells with an IC50 of 0.11 μM[1].
Tubulin polymerization-IN-90 (20 μM) induces significant release of human interleukin-8 (IL-8) from human peripheral blood mononuclear cells (hPBMCs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Wild-type CEM T cells, CEM-178 TUBB mutant cells
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Concentration:Serially diluted concentrations
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Incubation Time:20 h
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Result:Inhibited cell viability with an IC50 of 0.09 μM in wild-type CEM cells and an IC50 of 0.11 μM in CEM-178 mutant cells, showing minimal difference in cytotoxicity between the two cell lines.
Chemical Information
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CAS No. 3006800-41-2
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Molecular Weight 354.43
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Formula C21H14N4S
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SMILES
C1(C=CC=C2)=C2C=CC=C1C3=CN(N=N3)C4=CC(C5=CC=CS5)=CN=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-90 Related Classifications
HY-182081 Related Classifications
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