Tubulin polymerization-IN-90 

Tubulin polymerization-IN-90 is a tubulin polymerization inhibitor. Tubulin polymerization-IN-90 disrupts tubulin polymerization by binding to the nocodazole-binding site on β-tubulin. Tubulin polymerization-IN-90 induces the release of extracellular vesicles marked by the tetraspanin CD63. Tubulin polymerization-IN-90 induces the release of IL-8 from cells. Tubulin polymerization-IN-90 reduces the viability of cancer cells. Tubulin polymerization-IN-90 can be used in the research of cancers such as acute T-lymphoblastic leukemia^[1].

Tubulin polymerization-IN-90 (Compound 39) (10 μM; 48 h) significantly enhances the activity of the CD63 extracellular vesicle release reporter gene in CD63 Tluc-CD9 EmGFP THP-1 cells^[1].
Tubulin polymerization-IN-90 (1-10 μM) inhibits tubulin polymerization in a dose-dependent manner^[1].
Tubulin polymerization-IN-90 (0.001-0.1 μM; 20 h) inhibits the viability of wild-type CEM T cells with an IC₅₀ of 0.09 μM; it also inhibits the viability of CEM-178 TUBB mutant cells with an IC₅₀ of 0.11 μM^[1].
Tubulin polymerization-IN-90 (20 μM) induces significant release of human interleukin-8 (IL-8) from human peripheral blood mononuclear cells (hPBMCs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

354.43

C₂₁H₁₄N₄S

3006800-41-2

C1(C=CC=C2)=C2C=CC=C1C3=CN(N=N3)C4=CC(C5=CC=CS5)=CN=C4

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• [1]. Shukla NM, et al. Structure-Activity Relationship Studies in Substituted Oxadiazoles as Inducers of Extracellular Vesicles. J Med Chem. 2026;69(6):6490-6507.  [Content Brief]