2655556-75-3
2655556-75-3
Chemical Structure
PF-07245303
- CAS No.: 2655556-75-3
- Formula:C25H32N6O2
- Molecular Weight:448.56
InChIKey: DVXKDRBZBOJVGG-JAUXOLPYSA-N
SMILES: CC1=C(C=C2NC(C3=NNC4=C3C[C@@H]5C[C@@]5(C4)C)=NC2=C1)N(C([C@@H](N6CCOCC6)C)=O)C
Biological Activity: PF-07245303 is a ITK/TRK inhibitor. PF-07245303 reduces the production of inflammatory cytokines such as IL-4 and IFNγ, and inhibits the phosphorylation of PLCγ1. PF-07245303 inhibits nerve growth factor-induced basophil activation and the phosphorylation of TRKA. PF-07245303 reduces oxazolone-induced ear swelling in mouse ear tissues. PF-07245303 is applicable to research related to atopic dermatitis[1].
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PF-07245303 | PF-07245303 is a ITK/TRK inhibitor. PF-07245303 reduces the production of inflammatory cytokines such as IL-4 and IFNγ, and inhibits the phosphorylation of PLCγ1. PF-07245303 inhibits nerve growth factor-induced basophil activation and the phosphorylation of TRKA. PF-07245303 reduces oxazolone-induced ear swelling in mouse ear tissues. PF-07245303 is applicable to research related to atopic dermatitis. | |||||||||||||||||||||
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