CENPV - centromere protein V Gene

Also Known as p30; PRR6; CENP-V; 3110013H01Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 201161

About CENPV

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:16,342,537-16,353,469 (from NCBI)

This gene has 7 transcripts (splice variants), 180 orthologues and 3 paralogues. Broad expression in small intestine (RPKM 17.0), duodenum (RPKM 16.5) and 25 other tissues.

Summary

Predicted to enable carbon-sulfur lyase activity and metal ion binding activity. Involved in pericentric heterochromatin assembly; positive regulation of cytokinesis; and regulation of chromosome organization. Acts upstream of or within ameboidal-type cell migration. Located in several cellular components, including midbody; nucleus; and spindle midzone. [provided by Alliance of Genome Resources, Apr 2022]

CENPV Products (1)

mRNA	Protein	Name
NM_181716.3	NP_859067.2	centromere protein V

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ameboidal-type cell migration	IDA IDA: Inferred from direct assay	19930468	GOA
involved in centromere complex assembly	IMP IMP: Inferred from mutant phenotype	18772885	GOA
involved in pericentric heterochromatin formation	IMP IMP: Inferred from mutant phenotype	18772885	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	18772885	GOA
involved in regulation of chromosome organization	IMP IMP: Inferred from mutant phenotype	18772885	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in kinetochore	IDA IDA: Inferred from direct assay	18772885	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	19930468	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12196509	GOA
located in spindle midzone	IDA IDA: Inferred from direct assay	18772885	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPV Protein Structure

GFA

0
100
200
272 a.a.

Protein Preferred Names	Protein Names
centromere protein V	nuclear protein p30

CENPV Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CENPV	Q7Z7K6	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	CENPV	Q7Z7K6	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	CENPV	Q7Z7K6	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	CENPV	Q7Z7K6	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	CENPV	Q7Z7K6	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	CENPV	Q7Z7K6	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	CENPV	Q7Z7K6	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	CENPV	Q7Z7K6	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	CENPV	Q7Z7K6	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	CENPV	Q7Z7K6	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	CENPV	Q7Z7K6	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	CENPV	Q7Z7K6	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	CENPV	Q7Z7K6	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	CENPV	Q7Z7K6	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	CENPV	Q7Z7K6	PRPH	Homo sapiens	P41219	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Histoplasmosis Retinitis	Histoplasmosis With Retinitis
Central Nervous System Hemangioma	Hemangioma Of Cns Hemangioma Of The Central Nervous System
Intracranial Primitive Neuroectodermal Tumor	Intracranial Pnet Intracranial Primitive Neuroectodermal Neoplasm
Diffuse Glomerulonephritis	Glomerulonephritis Diffuse
T-Cell Adult Acute Lymphocytic Leukemia	Acute Adult T-Cell Leukemia-Lymphoma Adult Precursor T Lymphoblastic Leukemia Atll T-Cell Adult Acute Lymphoblastic Leukemia
Askin'S Tumor	Askin Tumor Askin Tumour Askin'S Tumour
Extraosseous Ewing Sarcoma	Extraosseous Ewing'S Sarcoma Extraosseous Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Extraskeletal Ewing Sarcom Sarcoma Extraosseous Ewings Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Adult T-Cell Leukemia/Lymphoma	Adult T-Cell Leukemia Atll Adult T-Cell Leukaemia Adult T-Cell Leukaemia/Lymphoma Adult T-Cell Lymphoma T Cell Leukemia Lymphoma Adult Leukemia-Lymphoma, Adult T-Cell Leukemia, T-Cell Adult T-Cell Lymphoma/Leukemia
Ehrlichiosis	Human Ehrlichiosis He Hey
Tropical Spastic Paraparesis	Tropical Spastic Paraplegia Ham/Tsp Htlv-Associated Myelopathy Tropical Spastic Paralysis Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis Htlv-1-Associated Myelopathy/Tropical Spastic Paraparesis Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis Tsp Paraparesis Tropical Spastic Paraparesis, Tropical Spastic
Adult Acute Lymphocytic Leukemia	Adult Acute Lymphoid Leukemia Adult All

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02493	CENPV Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CENPV	MGD	MGI:1920389
Rattus norvegicus	CENPV	RGD	RGD:1565681
Bos taurus	CENPV	VGNC	VGNC:107269
Canis familiaris	CENPV	VGNC	VGNC:53316
Macaca mulatta	CENPV	VGNC	VGNC:99137
Others	CENPV	NCBI