PDCD11 - programmed cell death 11 Gene

Also Known as ALG4; NFBP; RRP5; ALG-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22984

About PDCD11

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,396,626-103,446,294 (from NCBI)

This gene has 7 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 12.3), skin (RPKM 7.7) and 25 other tissues.

Summary

PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]

PDCD11 Products (2)

mRNA Protein Name
NM_001411058.1 NP_001397987.1 protein RRP5 homolog isoform 1
NM_014976.2 NP_055791.1 protein RRP5 homolog isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
14624448 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14624448 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14624448 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD11 Protein Structure

S1

S1: S1 RNA binding domain (185 - 257)

S1

S1: S1 RNA binding domain (451 - 522)

S1

S1: S1 RNA binding domain (547 - 610)

S1

S1: S1 RNA binding domain (728 - 798)

S1

S1: S1 RNA binding domain (1035 - 1095)

Suf

Suf: Suppressor of forked protein (Suf) (1727 - 1868)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1871 a.a.
Protein Preferred Names Protein Names

protein RRP5 homolog

  • NF-kappa-B-binding protein

PDCD11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDCD11 Q14690 NFKB1 Homo sapiens P19838
Pull Down
14624448
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dentin Caries

  • Compound Dental Caries

  • Dental Caries Extending Into Dentine

  • Dental Caries Extending Into Dentin
Enamel Caries

  • Primary Dental Caries

  • Dental Caries Limited To Enamel

  • Simple Dental Cavity
Epididymo-Orchitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10189 PDCD11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PDCD11 MGD MGI:1341788
Macaca mulatta PDCD11 VGNC VGNC:75596
Bos taurus PDCD11 VGNC VGNC:32659
Canis familiaris PDCD11 VGNC VGNC:44335
Rattus norvegicus PDCD11 RGD RGD:1304933
Felis catus PDCD11 VGNC VGNC:64077
Others PDCD11 NCBI