2. Gene
  3. PDCD11 - programmed cell death 11 Gene

PDCD11 - programmed cell death 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ALG4; NFBP; RRP5; ALG-4

Gene ID: 22984 | Gene type: protein coding

About PDCD11

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,396,626-103,446,294 (from NCBI)

This gene has 7 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 12.3), skin (RPKM 7.7) and 25 other tissues.

Summary

PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]

PDCD11 Products(2)

mRNA Protein Name
NM_001411058.1 NP_001397987.1 protein RRP5 homolog isoform 1
NM_014976.2 NP_055791.1 protein RRP5 homolog isoform 2

PDCD11 Protein Structure

S1

S1: S1 RNA binding domain (185 - 257)

S1

S1: S1 RNA binding domain (451 - 522)

S1

S1: S1 RNA binding domain (547 - 610)

S1

S1: S1 RNA binding domain (728 - 798)

S1

S1: S1 RNA binding domain (1035 - 1095)

Suf

Suf: Suppressor of forked protein (Suf) (1727 - 1868)

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  • 1871 a.a.
Protein Preferred Names Protein Names

protein RRP5 homolog

NF-kappa-B-binding protein

Related Diseases

Diseases Alias
Dentin Caries

Compound Dental Caries

Dental Caries Extending Into Dentine

Dental Caries Extending Into Dentin
Enamel Caries

Primary Dental Caries

Dental Caries Limited To Enamel

Simple Dental Cavity
Epididymo-Orchitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10189 PDCD11 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PDCD11 MGD MGI:1341788
Macaca mulatta PDCD11 VGNC VGNC:75596
Bos taurus PDCD11 VGNC VGNC:32659
Canis familiaris PDCD11 VGNC VGNC:44335
Rattus norvegicus PDCD11 RGD RGD:1304933
Felis catus PDCD11 VGNC VGNC:64077