Thienodolin
Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 murine macrophage cells with an IC50 value of 17.2 μM. Thienodolin suppresses iNOS, blocks the degradation of IκBα, attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation.
For research use only. We do not sell to patients.
- CAS No.: 149127-27-5
- Formula: C11H7ClN2OS
- Molecular Weight:250.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Thienodolin (6.25-50 μM, 15 min pretreatment) inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 cells (IC50 = 17.2 μM)[1].
Thienodolin (6.25-50 μM, 5-18 h) suppresses iNOS expression in a dose-dependent manner at both mRNA and protein levels in LPS-stimulated RAW 264.7 cells[1].
Thienodolin (6.25-50 μM, 15 min pretreatment) blocks the degradation of IκBα, reduces the phosphorylation level of STAT1 at Tyr701 and attenuates NF-κB p65 accumulation in the nucleus in LPS-stimulated RAW 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-stimulated RAW 264.7 cells
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Concentration:6.25, 12.5, 25, 50 μM
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Incubation Time:15 min pretreatment
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Result:Blocked the degradation of IκBα.
Reduced the phosphorylation level of STAT1 at Tyr701.
Attenuated NF-κB p65 accumulation in the nucleus.
Chemical Information
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CAS No. 149127-27-5
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Molecular Weight 250.70
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Formula C11H7ClN2OS
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SMILES
O=C(C1=CC2=C(NC3=C2C=CC(Cl)=C3)S1)N
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Synonyms
MJ 286A
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Structure Classification
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Initial Source
Streptomyces albogriseolus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thienodolin Related Classifications
HY-N16376 Related Classifications
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