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Cat. No.: HY-W552702

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Tyrosinase-IN-29

Tyrosinase-IN-29 (compound 5c) is a potent inhibitor of tyrosinase abTYR (IC₅₀: 6.11 μM). Tyrosinase-IN-29 can be used to further study the inhibition of skin hyperpigmentation.

For research use only. We do not sell to patients.

CAS No.: 408335-66-0
Formula: C₁₀H₉NO₂
Molecular Weight:175.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Tyrosinase-IN-29 Chemical Structure

CAS No.: 408335-66-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Tyrosinase-IN-29 (compound 5c) is a potent inhibitor of tyrosinase abTYR (IC₅₀: 6.11 μM). Tyrosinase-IN-29 can be used to further study the inhibition of skin hyperpigmentation^[1].

IC₅₀ & Target

IC50: 6.11 μM (abTYR)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	2750 nM Compound: 13	Inhibition of human recombinant DAAO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay Inhibition of human recombinant DAAO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay	[PMID: 19438227]

Chemical Information

CAS No. 408335-66-0
Molecular Weight 175.18
Formula C₁₀H₉NO₂
SMILES

CC1=CC2=C(C=C1)NC(=O)C(=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jacobs ME, Petzer JP, Pretorius J, Cloete SJ, Crous C, Petzer A. Synthesis and evaluation of 3-hydroxyquinolin-2(1H)-one derivatives as inhibitors of tyrosinase. Bioorg Med Chem Lett. 2024 May 31;109:129823.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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