UDP-β-D-glucose disodium 

UDP-β-D-glucose disodium acts as a glycosyl donor and biosynthetic intermediate, and is also a stereoisomer of UDP-α-D-glucose^[1][2][3].

UDP-β-D-glucose (19u) disodium acts as the exclusive donor substrate for purified AprO from Streptomyces tenebrarius to catalyze glycosylation of aprosamine 5-phosphate, forming saccharocin (HY-106590) 5-phosphate^[1].
UDP-β-D-glucose disodium undergoes transamination catalyzed by purified AprD5 and AprL from Streptomyces tenebrarius to form UDP-4″-amino-4″-deoxy-β-D-glucose, which serves as a donor substrate for AprO to produce Apramycin (HY-17558)^[1].
UDP-β-D-glucose (substrate level; several hours) acts as the sugar donor for mammalian UDP-glucosyltransferases to glucosidate tea polyphenols in microsomal systems in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

610.27

C₁₅H₂₂N₂Na₂O₁₇P₂

7333-33-7

Solid

White to off-white

O[C@H]1[C@H](O)[C@@H](O)[C@H](O[P](O[P](OC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=CC(NC3=O)=O)O2)(O[Na])=O)(O[Na])=O)O[C@@H]1CO

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Sato S, et al. Complete In Vitro Reconstitution of the Apramycin Biosynthetic Pathway Demonstrates the Unusual Incorporation of a β-d-Sugar Nucleotide in the Final Glycosylation Step. J Am Chem Soc. 2024;146(14):10103-10114.

  [2]. Sang S, et al. The chemistry and biotransformation of tea constituents. Pharmacol Res. 2011;64(2):87-99.  [Content Brief]

  [3]. Hundt K, et al. Transformation of triclosan by Trametes versicolor and Pycnoporus cinnabarinus. Appl Environ Microbiol. 2000;66(9):4157-4160.