Transformation of triclosan by Trametes versicolor and Pycnoporus cinnabarinus

  • Appl Environ Microbiol. 2000 Sep;66(9):4157-60. doi: 10.1128/AEM.66.9.4157-4160.2000.
K Hundt  1 ,  D Martin ,  E Hammer ,  U Jonas ,  M K Kindermann ,  F Schauer
Affiliations
  • 1. Institute of Microbiology and Molecular Biology, Ernst-Moritz-Arndt-University, D-17487 Greifswald, Germany. [email protected]
PMID: 10966448 DOI: 10.1128/AEM.66.9.4157-4160.2000
Abstract

We investigated the ability of Trametes versicolor and Pycnoporous cinnabarinus to metabolize triclosan. T. versicolor produced three metabolites, 2-O-(2,4,4'-trichlorodiphenyl ether)-beta-D-xylopyranoside, 2-O-(2,4,4'-trichlorodiphenyl ether)-beta-D-glucopyranoside, and 2,4-dichlorophenol. P. cinnabarinus converted triclosan to 2,4, 4'-trichloro-2'-methoxydiphenyl ether and the glucoside conjugate known from T. versicolor. The conjugates showed a distinctly lower cytotoxic and microbicidal activity than triclosan did.

Products